Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

Magalhães, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, R. M.; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Câmara, Rafael Barros Gomes; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araújo; Costa, Mariana Santana Santos Pereira; Alves, Luciana G.; Rocha, Hugo Alexandre Oliveira

doi:10.3390/ijms12053352

Cited by 86 publications

(51 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In hydroxyl scavenging assay and ferrous chelating, no activity was found, although, this result is similar to the most of sulfated polysaccharides reported in literature that displayed very low activity in these assays (Magalhães et al, 2011). However, sulfated heterofucans from Padina gymnospora (Souza et al, 2007), as well as, sulfated homofucans from Fucus vesiculosus and Laminaria japonica (Souza et al, 2007;Wang et al, 2008), have high activity as hydroxyl radical scavengers.…”

Section: Discussionsupporting

confidence: 56%

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Silva¹,

Dantas-Santos²,

Gomes³

et al. 2012

Rev. bras. farmacogn.

Self Cite

View full text Add to dashboard Cite

Abstract:A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane ® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.

show abstract

Section: Discussionsupporting

confidence: 56%

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Silva¹,

Dantas-Santos²,

Gomes³

et al. 2012

Rev. bras. farmacogn.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, researchers often use the reducing power as an important standard for evaluating the antioxidant ability [28, 29]. Commonly, the reduction of three-valent iron ion to two-valent iron ion is determined at the absorbance 700 nm, and ascorbic acid is used as control in assay of reduction ability.…”

Section: Resultsmentioning

confidence: 99%

Optimization of Alkaline Extraction and Bioactivities of Polysaccharides from Rhizome ofPolygonatum odoratum

Chen

Yin

Zhang

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

The present study is to explore the optimal extraction parameters, antioxidant activity, and antimicrobial activity of alkaline soluble polysaccharides from rhizome of Polygonatum odoratum. The optimal extraction parameters were determined as the following: NaOH concentration (A) 0.3 M, temperature (B) 80°C, ratio of NaOH to solid (C) 10-fold, and extraction time (D) 4 h, in which ratio of NaOH to solid was a key factor. The order of the factors was ratio of NaOH to solid (fold, C) > extraction temperature (°C, B) > NaOH concentration (M, A) > extraction time (h, D). The monosaccharide compositions of polysaccharides from P. odoratum were rhamnose, mannose, xylose, and arabinose with the molecular ratio of 31.78, 31.89, 11.11, and 1.00, respectively. The reducing power, the 1, 1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging rate, the hydroxyl radicals scavenging rate, and the inhibition rate to polyunsaturated fatty acid (PUFA) peroxidation of the alkaline soluble polysaccharides from P. odoratum at 1 mg/mL were 9.81%, 52.84%, 19.22%, and 19.42% of ascorbic acid at the same concentration, respectively. They also showed antimicrobial activity against pathogenic bacteria Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.

show abstract

“…Fucans from various seaweeds, including different Dictyotales [3,4], possess anticoagulant activity. In this way, we evaluated the anticoagulant activity of the Fuc C test by Prothrombin time (PT) and Partial thromboplastin time (APTT).…”

Section: Resultsmentioning

confidence: 99%

“…They are a family of homo- and hetero-polysaccharides having in its constitution monomer sulfated l -fucose [3]. Recent studies have demonstrated that fucans presented various pharmacological activities, such as: anticoagulant [4], antioxidant [5], immune modulator [6], anti-viral [7,8], anti-inflammatory [9] and anti-tumoral [10]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

et al. 2013

View full text Add to dashboard Cite

Fucan is a term that defines a family of homo- and hetero-polysaccharides containing sulfated l-fucose in its structure. In this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-α). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. In summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.

show abstract

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

Cited by 86 publications

References 35 publications

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Optimization of Alkaline Extraction and Bioactivities of Polysaccharides from Rhizome ofPolygonatum odoratum

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

Contact Info

Product

Resources

About