Deep venous thrombosis continues to be a frequent complication of surgery and trauma. The topic is controversial with regard to diagnosis, indication for prophylaxis, and suitable methods for prophylaxis and therapy. We review some of the highlights of the extensive literature in this field during the last few years. Particular emphasis is given to new trends in diagnostic methods, newly discovered genetic factors for thrombophilia, and the use of heparins for prophylaxis and therapy of thromboembolic disease.