Anticoagulation and Antiplatelet Effects of Semax under Conditions of Acute and Chronic Immobilization Stress

Grigorjeva, M.; Lyapina, L. A.

doi:10.1007/s10517-010-0871-x

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…The authors suggest that Semax, especially in combination with heparin, may be a promising antithrombotic agent [213]. Repeated intranasal administration of Semax at a dose of 1000 μg/kg in a hypercoagulation state caused by immobilization stress of varying degrees yielded a powerful protective antistress effect, which stimulated the anticoagulation system [214].…”

Section: Discussionmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products; thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH 4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the influence of these peptides on the transcriptome of brain cells. The problems of drugs developed based on the clinical activities of Semax and Selank are discussed separately.

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Section: Discussionmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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“…В настоящее время в литературе имеются данные о механизмах взаимодействия АКТГ 4-7 -PGP с компонентами системы гемостаза. Так, показано усиление антикоагулянтного и фибринолитического потенциала плазмы (общая фибринолитическая активность, активность активатора плазминогена) и снижение концентрации антиплазмина на фоне интраназального введения семакса [30,36]. Подобные эффекты семакса, в том числе антиагрегационный в отношении тромбоцитов, были продемонстрированы в условиях однократного и многократного стрессорного воздействия путем иммобилизации.…”

Section: влияние на сердечно-сосудистую систему печень и гемостазunclassified

Регуляторные Пептиды Семейства Меланокортинов: Биосинтез, Рецепция, Биологические Эффекты

Dodonova¹,

Белых²,

Бобынцев³

2018

Курск. науч.-практ. вестн. «Человек и его здоровье»

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В обзоре выполнен анализ данных литературы о биосинтезе, рецепции, деградации и физиологических эффектах регуляторных пептидов семейства меланокортинов. Представлены данные о взаимодействии меланокортинов с нейромедиаторами головного мозга, а также их влиянии на функциональное состояние регуляторных систем организма. Отражены нейротропные и иммунотропные эффекты пептидов семейства меланокортинов, а также их влияние на отдельные органы и системы, в частности: печень, сердечно-сосудистую систему и гемостаз. Описаны основные фармакологические эффекты и механизмы действия созданного на основе синтетического фрагмента АКТГ препарата «Семакс». Приведенные в обзоре данные отражают обоснованные значительным количеством исследований представления о высокой физиологической активности и полифункциональности регуляторных пептидов семейства меланокортинов, а также перспективность создания на их основе новых фармакологических препаратов.

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Semax, an analog of ACTH(4−7), regulates expression of immune response genes during ischemic brain injury in rats

et al. 2017

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Brain stroke continues to claim the lives of million people every year. To build the effective strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent the ischemic injury. Consisting of the ACTH fragment and the tripeptide Pro-Gly-Pro (PGP), the synthetic peptide Semax effectively protects brain against ischemic stroke. However, the molecular mechanisms underlying its neuroprotection and participation of PGP in them are still needed to be clarified. To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides. The genome-wide biochip data analysis detected the differentially expressed genes (DEGs) and bioinformatic web-tool Ingenuity iReport found DEGs associations with several biological processes and signaling pathways. The immune response is the process most markedly affected by the peptide: Semax enhances antigen presentation signaling pathway, intensifies the effect of ischemia on the interferon signaling pathways and affects the processes for synthesizing immunoglobulins. Semax significantly increased expression of the gene encoding the immunoglobulin heavy chain, highly affects on cytokine, stress response and ribosomal protein-encoding genes after occlusion. PGP treatment of rats with ischemia attenuates the immune activity and suppresses neurotransmission in the CNS. We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of PGP were found under ischemia. Our results provided the basis for further proteomic investigations in the field of searching Semax neuroprotection mechanism.

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Anticoagulation and Antiplatelet Effects of Semax under Conditions of Acute and Chronic Immobilization Stress

Cited by 7 publications

References 10 publications

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Регуляторные Пептиды Семейства Меланокортинов: Биосинтез, Рецепция, Биологические Эффекты

Semax, an analog of ACTH(4−7), regulates expression of immune response genes during ischemic brain injury in rats

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