Anticoccidial and Tolerance Studies in the Chicken with Two 6-Amino-9-(substituted benzyl)purines

Miller, Barry W.; McManus, Edward C.; Olson, Gregory J.; Schleim, Klaus D.; Iderstine, A. Ann Van; Graham, Donald W.; Brown, J. E.; Rogers, Edward F.

doi:10.3382/ps.0562039

Cited by 17 publications

(5 citation statements)

References 4 publications

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“…A decrease in relative weight gain was observed at the 90 ppm level of arprinocid. This observation is consistent with previously reported published data from this laboratory (Miller et al, 1977) showing that 90. ppm arprinocid exceeds the maximum tolerated die- DP-667 and DP-669 were not tested at these levels. DP-714 was not tested at these levels.…”

Section: Laboratory Responses Of Field Isolates Tosupporting

confidence: 96%

“…As part of our ongoing search for new coccidiostats, 9-[(2-chloro-6-fluorophenyl)methyl] -9//-purin-6-amine (arprinocid) shown in Figure 1 has been selected from a series of benzyl purine derivatives for intensive investigation on the basis of safety and broadspectrum anticoccidial efficacy (Miller et al, 1977). During these studies, arprinocid was tested in controlled battery experiments against 20 recent field isolates of coccidia representing the five major species isolated from widely separated locations.…”

Section: Introductionmentioning

confidence: 99%

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Battery Efficacy Studies with Arprinocid against Field Strains of Coccidia

et al. 1978

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Graded levels of 9-[2-chloro-6-fluorophenyl)methyl]-9H-purin-6-amine (arprinocid) ranging from 30 ppm to 90 ppm in the diet have been tested for anticoccidial efficacy in controlled battery experiments against 20 field isolates of coccidia. These isolates, representing five major species of Eimeria, were collected from various geographic locations and all but one were found to be resistant to one or more of the currently marketed products. Arprinocid prevented mortality, increased weight gains, and reduced or eliminated intestinal lesions and oocyst production. A level of 60 ppm arprinocid provided adequate control of all isolates and no evidence of cross resistance was observed between arprinocid and the marketed products tested. On the basis of these studies, it is concluded that arprinocid at levels of 60 ppm to 70 ppm is effective in controlling coccidiosis in broilers, even that caused by isolates refractory to many of the marketed products.

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Section: Laboratory Responses Of Field Isolates Tosupporting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Battery Efficacy Studies with Arprinocid against Field Strains of Coccidia

et al. 1978

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“…The efficacy of arprinocid 1 against coccidiosis in broiler chickens has been fairly established in laboratory and floor-pen tests (Ruff et al, 1978a;Kilgore et al, 1978;Miller et al, 1977). The unusual property of the effect on sporulation of oocysts from birds fed the drug and lowered infectivity of oocysts that do sporulate (Lira et al, 1974;Joyner and Norton, 1978;Tamas et al, 1978;Ruff et al, 1978b) further add interest to this group of compounds.…”

Section: Introductionmentioning

confidence: 93%

Floor Pen Studies on the Anticoccidial Efficacy of Arprinocid in Turkeys

McDougald

Johnson

1979

Poultry Science

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Arprinocid was tested against coccidiosis in turkeys reared in floor pens. Contamination of pens with Eimeria meleagrimitis, E. adenoeides, and E. gallopavonis was accomplished by the infected seeder bird technique. Performance improved with increasing levels of arprinocid through 120 ppm, but weight gains were depressed at 180 ppm. Lesion scores were significantly and progressively reduced by treatment with 60, 90, 120, and 180 ppm of arprinocid. Control of lesion scores and performance of birds treated with 120 ppm of arprinocid were comparable to the amprolium (125 ppm) treatment. In a separate experiment, the oocyst passage of E. meleagrimitis and of E. adenoeides was progressively reduced by increasing levels of arprinocid, and sporulation rate was decreased. Sportulation was not obtained in oocysts from birds fed arprinocid at 120 ppm or higher.

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“…In battery and floor-pen investigations in the United States, Kilgore et al (1978) and Miller et al (1977) demonstrated that arprinocid or MK-302 (9-[(2-chloro-6-fluorophenyl)methyl] -9H-purin-6-amine) administered in the feed has broad-spectrum activity against chicken coccidia. Unpublished battery studies with 99 isolates of Eimeria acervulina, E. acervulina var.…”

Section: Introductionmentioning

confidence: 99%

Arprinocid Evaluation in Broiler Chicken Pen Trials in Europe

et al. 1979

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The effect of arpinocid (9-[2-chloro-6-fluorophenyl)methyl]-9H-purin-6-amine) on artificial and natural coccidial infections in broiler chickens was evaluated in a series of pen trials conducted in England, France, and Germany. In trials with induced infections, mortality attributable to coccidiosis did not occur at 50, 60, and 70 ppm although it ranged from 3.2 to 9% in unmedicated groups. At 7 to 8 weeks of age, birds receiving arprinocoid in feed at levels of 40, 50, 60, and 70 ppm had improved body weights and feed conversion compared with unmedicated birds, the differences being significant (P is less than .05) in 4 out of 5 trials. Productivity of birds on arprinocid was equivalent or significantly superior (P is less than 0.5) to those on halofuginone (3 ppm), monensin (100 ppm), nicarbazin (125 ppm), and PANCOXIN (165 ppm). Based on the results of these pen trials, arprinocid at levels of 50 to 70 ppm in feed is a highly efficacious compound for the prophylaxis of coccidiosis, preventing mortality, and permitting good growth and feed conversion under conditions of both mild and severe infection pressure.

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Anticoccidial and Tolerance Studies in the Chicken with Two 6-Amino-9-(substituted benzyl)purines

Cited by 17 publications

References 4 publications

Battery Efficacy Studies with Arprinocid against Field Strains of Coccidia

Battery Efficacy Studies with Arprinocid against Field Strains of Coccidia

Floor Pen Studies on the Anticoccidial Efficacy of Arprinocid in Turkeys

Arprinocid Evaluation in Broiler Chicken Pen Trials in Europe

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