Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures

Sayyah, Mohammad; Valizadeh, Jafar; Kamalinejad, Mohammad

doi:10.1078/0944-7113-00113

Cited by 129 publications

(95 citation statements)

References 17 publications

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“…The animals were individually placed in plastic cases and observed immediately after PTZ injection for 30 min. The onset and duration of myoclonic jerks/ convulsions as well as the percentage of protection against mortality were recorded (Hosseinzadeh & Khosravan, 2002;Sayyah et al, 2002;Sonavane et al, 2002).…”

Section: Pentylenetetrazole (Ptz)-induced Seizurementioning

confidence: 99%

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Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Kumar¹,

Singh²,

Baghotia³

et al. 2010

Rev. bras. farmacogn.

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ABSTRACT:In this study, ethanol extract of Caesalpinia pulcherrima (L.) Sw., Fabaceae, leaves (CPEE) was investigated for anticonvulsant effect against maximal electroshock (MES) and pentylenetetrazole (PTZ) induced seizures in rats and mice at dose levels 200 and 400 mg/ kg, i.p. respectively. Diazepam (3 mg/kg, i.p.) was used as a standard anticonvulsant drug for comparison. CPEE was found to be safe up to the dose of 4000 mg/kg in mice, when administered intraperitoneally. The extract at 400 mg/kg dose produced significant (p<0.01) anticonvulsant effect w.r.t. control against PTZ-induced clonic seizures. In MES-induced seizure model, there were no significant alterations in the onset as well as duration of hind limb extension seizures as compared to control at a dose of 200 mg/kg when administered intraperitoneally. However, the extract (CPEE, 400 mg/kg i.p.) significantly (p<0.01) delayed the onset as well as decreased the duration of hind limb extension seizures (HLES) as compared to control. However, the extract, CPEE, percentage protection of the animals was increased at higher dose (200 mg/kg) in both the models. The results of the study suggest that ethanol extract of Caesalpinia pulcherrima (L.) Sw. leaves possess anticonvulsant effect.

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Section: Pentylenetetrazole (Ptz)-induced Seizurementioning

confidence: 99%

“…Hind-limb tonic extensions of the rats were regarded as manifestations of seizures. The onset and duration of hind limb tonic-clonic seizures or convulsions as well as the percentage of protection against mortality were recorded (Hosseinzadeh & Khosravan, 2002;Sayyah et al, 2002;Sonavane et al, 2002).…”

Section: Mes-induced Seizuresmentioning

confidence: 99%

Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Kumar¹,

Singh²,

Baghotia³

et al. 2010

Rev. bras. farmacogn.

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“…The duration of various phases of epilepsy were observed (Sayyah et al, 2000;Balakrishnan et al, 1998).…”

Section: Maximum Electroshock-induced Seizuresmentioning

confidence: 99%

Antiepileptic and central nervous system depressant activity of <i>Sechium edule</i> fruit extract

Mumtaz¹,

Ahmed

Dey

2012

Bangladesh J Pharmacol

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Preparation of ethanol extractThe fruits of S. edule were isolated, chopped and dried at room temperature for seven days. The dried materials were powdered by using mixer grinder. The powder was first defatted with petroleum ether (60-80 GR) for 72 hours and then the extraction of dried AbstractThe effect of ethanol extract of fruits of Sechium edule on antiepileptic and central nervous system (CNS) depressant model was studied in rats. The extract (200 mg/kg body weight, orally) significantly reduced the duration of various phases of convulsions in both MES-induce seizures and in PTZinduced convulsion. In CNS depressant model, the locomotor activity was also decreased in a dose dependent manner as compared to control group the extract and the rota rod test revealed a significant loss of muscular coordination.

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“…Seizures were manifested as hind limb tonic extension (HLTE) (Swinyard, 1969). The ability to prevent this feature or prolong the latency and/or onset of the HLTE was considered as an indication of anticonvulsant activity (Sayyah et al, 2002;Swinyard, 1969). The same procedure was repeated to evaluate column fractions (S1 and S2) of RAF.…”

Section: Maximal Electroshock-induced Convulsion In Chicksmentioning

confidence: 99%

“…The method described by Swinyard and Kupferberg (1985), as modified by Sayyah et al (2002), was used in the study. About 50 one-day old cockerels were randomly divided into five groups of 10 chicks per group.…”

Section: Maximal Electroshock-induced Convulsion In Chicksmentioning

confidence: 99%

Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

Ya’u

Yaro

Malami

et al. 2015

Pharmaceutical Biology

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Context: Carissa edulis Vahl (Apocynaceae) is used in Nigerian folk medicine to manage a plethora of diseases including epilepsy, cancer, and inflammation; its efficacy is widely acclaimed among communities of northern Nigeria. Objective: This study establishes anticonvulsant activities of aqueous fraction of ethanol root bark extract of Carissa edulis (RAF) and sub-fractions (S1 and S2) in animal models. Materials and methods:We evaluated the acute toxicity of the RAF, S1 and S2, and the anticonvulsant activity using pentylenetetrazole (PTZ), picrotoxin, strychnine, N-methyl-Daspartate (NMDA), isoniazid (INH), and aminophylline-induced seizures in mice. Their effects on maximal electroshock (MES) and kindling-induced seizures were studied in chicks and in rats, respectively, and in the electrophysiological study. The doses used for RAF were 150, 300, and 600 mg/kg while S1 and S2 were 250, 500, and 1000 mg/kg. Both RAF and sub-fractions were administered once during the experiment. Results: The intraperitoneal LD 50 of the RAF was estimated to be 2222.61 mg/kg and that of the S1 and S2 were above 5000 mg/kg. RAF protected the mice by 50% while sub-fractions by 16.67% against PTZ-induced seizures. RAF offered 33.33 and 16.67% protection against strychnine and NMDA models, respectively. However, RAF offered 66.67-33.33% protections against aminophylline-induced seizures at doses of 150 and 600 mg/kg, but RAF, S1, and S2 had no effect on MES-induced seizures. Discussion and conclusion: Our results validate the use of the plant traditionally in the management of epilepsy, thus supporting the appraisal of biologically active components of this plant as antiepileptic agents.

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Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures

Cited by 129 publications

References 17 publications

Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Antiepileptic and central nervous system depressant activity of <i>Sechium edule</i> fruit extract

Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

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