No abstract

No abstract

Preparation of ethanol extractThe fruits of S. edule were isolated, chopped and dried at room temperature for seven days. The dried materials were powdered by using mixer grinder. The powder was first defatted with petroleum ether (60-80 GR) for 72 hours and then the extraction of dried AbstractThe effect of ethanol extract of fruits of Sechium edule on antiepileptic and central nervous system (CNS) depressant model was studied in rats. The extract (200 mg/kg body weight, orally) significantly reduced the duration of various phases of convulsions in both MES-induce seizures and in PTZinduced convulsion. In CNS depressant model, the locomotor activity was also decreased in a dose dependent manner as compared to control group the extract and the rota rod test revealed a significant loss of muscular coordination.