Effect of &lt;i&gt;Sechium edule&lt;/i&gt; on chemical induced kidney damage in experimental animals

Mumtaz, Sayeed Mohammed Firdous; Paul, Sabu; Bag, Anupam Kanti

doi:10.3329/bjp.v8i1.12982

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…The effects observed included: (a) a reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, and hepatic lipid peroxidation and (b) a hike in the levels of antioxidant markers, such as hepatic glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and total protein in a dose-dependent manner. Also, the aqueous extract of chayote leaves possessed a protective effect against gentamicin-and potassium dichromate-induced nephrotoxicity and streptozotocin-induced diabetic nephropathy (Mumtaz, Paul, & Bag, 2012b).…”

Section: Hepatoprotective Propertiesmentioning

confidence: 99%

Chayote (Sechium edule): A review of nutritional composition, bioactivities and potential applications

et al. 2019

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Chayote (Sechium edule) has gained widespread consuming acceptance and recognized by its nutritional and bio-functional properties. The present review surveys and describes the current findings about the nutritional, phytochemical and pharmacological properties of chayote and identifies opportunities for further research. It also discusses chayote's versatile utility in nutrition, as a functional ingredient in food, cosmetic and pharmaceutical industries, as well as in nanotechnology and biotechnological processes. It was concluded that although the pharmacological properties of chayote are currently well-established, only a few reports have been conducted on the isolation and identification of individual chemical constituents, and similarly, only a few in vivo studies have been conducted to assess their biological efficacy. In addition, the valorisation of the underutilized chayote by-products can be an important aspect in waste management from both economic and environmental standpoints. Thus, the recovery and utilization of valuable compounds from chayote is an important challenge for scientists.

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Section: Hepatoprotective Propertiesmentioning

confidence: 99%

Chayote (Sechium edule): A review of nutritional composition, bioactivities and potential applications

et al. 2019

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“…Sechium edule (Jacq.) Sw. is an edible plant species of Mesoamerican origin whose fruit extract contains nonphenolic alkaloids, saponins, sterols, triterpenoids, flavonoids, and phenolic acids [ 5 ], as well as glycosylated flavonoids [ 6 ], with antihypertensive [ 7 ], antimicrobial [ 8 ], antioxidant [ 9 ], antitumor [ 10 ], nephroprotective [ 11 ], anti-inflammatory and hepatoprotective properties [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antioxidant and Anti-Inflammatory Capacity of the Extracts of Fruits of the Sechium Hybrid

et al. 2020

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In addition to their own antioxidants, human cells feed on external antioxidants, such as the phenolic compounds of fruits and vegetables, which work together to keep oxidative stress in check. Sechium edule, an edible species of chayote, has phenolic compounds with antioxidant activity and antineoplastic activity. A Sechium hybrid shows one thousand times greater antineoplastic activity than edible species, but its antioxidant and anti-inflammatory activities and the content of phenolic compounds are unknown. The aim of this study was to determine the antioxidant and anti-inflammatory capacity of the extract of fruits of the Sechium hybrid in vitro and in vivo. Phytochemical analysis using HPLC showed that the extract of the Sechium hybrid has at least 16 phenolic compounds; galangin, naringenin, phloretin and chlorogenic acid are the most abundant. In an in vitro assay, this extract inhibited 2,2-diphenyl-L-picrylhydrazyl (DPPH) activity and protected the dimyristoylphosphatidylethanolamine (DMPE) phospholipid model cell membrane from oxidation mediated by hypochlorous acid (HClO). In vivo, it was identified that the most abundant metabolites in the extract enter the bloodstream of the treated mice. On the other hand, the extract reduces the levels of tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), and interleukin-6 (IL-6) but increases interleukin-10 (IL-10) and glutathione peroxidase levels. Our findings indicate that intake of the fruits of the Sechium hybrid leads to antioxidant and anti-inflammatory effects in a mouse model. Therefore, these results support the possibility of exploring the clinical effect of this hybrid in humans.

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“…More interest has developed to the protective effects of medicinal plants against chemically induced toxicities (Frei and Higdon, 2003). For example, Azima tetracantha (Konda et al, 2016) and Capparis spinosa (Tlili et al, 2017), Cestrum nocturnum (Saleem et al, 2017), Morus alba (Ullah et al, 2016), Nigella sativa (Begum et al, 2006), Sechium edule (Mumtaz et al, 2012), Terminalia muelleri (Fahmy et al, 2016) show nephroprotective effect.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

Pervez

Saeed

Khan

et al. 2018

Bangladesh J Pharmacol

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The present study was conducted to explore the protective effect of B. baluchistanica against gentamicin-induced renal toxicity in rabbits. Phytochemical investigations lead to the isolation of berberine and palmatine. The crude hydro-methanolic extract at various doses (100, 200 and 300 mg/kg body weight) elicited strong nephroprotective effects by restoring various biomarkers which were deranged by gentamicin such as creatinine, urea, serum uric acid levels (p<0.001) in plasma and urine output creatinine clearance, urinary protein and γ-glutamyl transferase level (p<0.001) in urine in a dose dependent manner. The mediators involved in oxidative stress such malondialdehyde, reduced glutathione, glutathione peroxidase, and catalase levels were significantly (P˂0.05-0.001) modulated in kidney tissue homogenate. Correspondingly, there is a significant (P<0.05) recovery in kidney weight and % loss in body weight compare to GM group. From these results, it is possible that B. baluchistanica exhibited protective effect mediated through the presence of berberine and palmatine.Video Clip of Methodology:Histopathology: 7 min 24 sec <a href="https://www.youtube.com/v/VNa-fDMRosA">Full Screen</a> <a href="https://www.youtube.com/watch?v=VNa-fDMRosA">Alternate</a>

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Effect of <i>Sechium edule</i> on chemical induced kidney damage in experimental animals

Cited by 12 publications

References 15 publications

Chayote (Sechium edule): A review of nutritional composition, bioactivities and potential applications

Chayote (Sechium edule): A review of nutritional composition, bioactivities and potential applications

Phytochemical Analysis and Antioxidant and Anti-Inflammatory Capacity of the Extracts of Fruits of the Sechium Hybrid

Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

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