Anticonvulsant effects of acute treatment with cyane-carvone at repeated oral doses in epilepsy models

Marques, Thiago Henrique Costa; Marques, Maria Leonildes Boavista Gomes Castelo Branco; Medeiros, Jand Venes R.; Lima, Tamires Cardoso; Sousa, Damião Pergentino de; Freitas, Rivelilson Mendes de

doi:10.1016/j.pbb.2014.06.016

Cited by 13 publications

(2 citation statements)

References 21 publications

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“…In addition, another study was conducted on models of epilepsy by Marques et al [ 109 ] to study the effects of CC against seizures induced by pilocarpine (PILO), pentylenetetrazole (PTZ), and picrotoxin (PTX) in mice. After acute CC treatment at repeated oral doses (25 mg/kg, 50 mg/kg, and 75 mg/kg) for 14 days, positive anticonvulsant effects in PILO, PTZ, and PTX epilepsy models were recorded.…”

Section: Resultsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Carvone

et al. 2021

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Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.

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Section: Resultsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Carvone

et al. 2021

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“…It is a known antimicrobial [ 40 , 41 ], anti-inflammatory [ 42 , 43 ], anti-arthritis [ 44 ], anticancer [ 45 ], liver-protective [ 46 ], cardioprotective [ 47 ], calming and neuroprotective [ 48 , 49 , 50 ] agent. It is also an anticonvulsant, suggested as a potential treatment for epilepsy [ 51 ]. The combination of these three powerful plant products in the form of commercial phytogenic supplement is expected to display a combination of the benefits of its basic ingredients.…”

Section: Introductionmentioning

confidence: 99%

Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone

Bajagai

Petranyi

Horyanto

et al. 2022

Heliyon

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Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential

Firdaus

Habib

Siddiqui

et al. 2018

Archiv der Pharmazie

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A series of newer benzothiazolotriazine derivatives (4a-k) was designed, synthesized, and characterized as anticonvulsant agents against the two classically used MES and scPTZ animal models. The synthesized derivatives were tested in vivo in both the animal models, followed by a neurotoxicity study by the rotarod method. Compound 3,5]triazine was found most promising among the series in both the animal models, with no neurotoxicity. From this it may be confirmed that the presence of a methoxy (OCH 3 ) group at the lipophilic aryl ring was showing high anticonvulsant potency. In the molecular modeling study, compound 4e (docking score = −8.70) showed important hydrogen bond interaction with the amino acids LYS 329, SER 137, GLY 136 and π-π interactions with PHE 189 at the active site of GABA-AT. These derivatives can be further explored for the development of newer/novel anticonvulsant agents. K E Y W O R D S

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Anticonvulsant effects of acute treatment with cyane-carvone at repeated oral doses in epilepsy models

Cited by 13 publications

References 21 publications

Health Benefits and Pharmacological Properties of Carvone

Health Benefits and Pharmacological Properties of Carvone

Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone

Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential

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