2001
DOI: 10.1016/s0378-8741(01)00192-1
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Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae)

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Cited by 104 publications
(52 citation statements)
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“…The tested fractions have been found to exert anticonvulsant effect due to their potent ability to increase the time of onset of convulsions and to decrease the time of duration of convulsions caused by administration of PTZ. The strong anticonvulsant action of A. rosea against PTZ-induced convulsions might be due to their action as a GABA agonist (Bum et al, 2001). …”
Section: Discussionmentioning
confidence: 99%
“…The tested fractions have been found to exert anticonvulsant effect due to their potent ability to increase the time of onset of convulsions and to decrease the time of duration of convulsions caused by administration of PTZ. The strong anticonvulsant action of A. rosea against PTZ-induced convulsions might be due to their action as a GABA agonist (Bum et al, 2001). …”
Section: Discussionmentioning
confidence: 99%
“…The tested fractions have been found to exert anticonvulsant effect due to their potent ability to increase the time of onset of convulsions and to decrease the time of duration of convulsions caused by administration of PTZ (Figure 1). The strong anticonvulsant action of B. calliobotrys against PTZ-induced convulsions might be due to their action as a GABA agonist [20]. In addition, strychnine, another very potent convulsant has been shown to act on the spinal cord and produce an inhibitory effect on the inhibitory neurotransmitter glycine, which produces hyper excitability in CNS and ultimately convulsions [21].…”
Section: Discussionmentioning
confidence: 99%
“…It has often been stated that anticonvulsant drugs that prevent tonic extension of MES act by blocking spread of seizure whereas drugs that either prevents or delays seizure of PTZ, act by elevating the seizure threshold [15].…”
Section: Discussionmentioning
confidence: 99%