Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Brunner, Jürgen; Sitzmann, Friedrich Carl

doi:10.3109/s10165-006-0520-4

Cited by 9 publications

(12 citation statements)

References 4 publications

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“…Numerous studies have shown that IgM RF-positive polyarthritis patients have a higher prevalence of anti-CCP antibodies [36][37][38][39][40][41][42][43][44]45 We have also shown that the measurement of IgA, IgM, and IgG anti-CCP antibody isotypes early in the course of JIA may be beneficial to distinguish aggressive disease and possibly initiate more aggressive treatment earlier in those patients [48•]. These patients have been shown to have higher immune complex levels by the anti-Fc III method of detection and are noted to have increased disease activity [49•].…”

Section: Discussionmentioning

confidence: 99%

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Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Syed

Gilliam²,

Moore

2008

Curr Rheumatol Rep

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Juvenile idiopathic arthritis (JIA) is a heterogenous childhood disease without reliable biomarkers for monitoring disease progression. Immunoglobulin (Ig) M rheumatoid factor (RF) is used to define a subset of JIA patients, but its significance in JIA is dependent on the method of measurement. In addition to IgM RF, IgA RF has been implicated in determining disease severity in JIA, including functional disability and joint damage. Anticyclic citrullinated peptide (anti-CCP) antibodies have been a valuable diagnostic tool in rheumatoid arthritis, with varied results in their significance in JIA patients. Recent studies have demonstrated the possible usefulness of isotypes of anti-CCP antibodies in monitoring JIA patients to determine disease outcome. Overall, RF isotypes and anti-CCP isotypic antibodies have demonstrated increasing importance in the evaluation of JIA patients to determine which patients may have more aggressive or severe disease and to aid in possible treatment plans to prevent joint damage and disability.

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Section: Discussionmentioning

confidence: 99%

“…Brunner and Sitzmann [43] studied 45 JIA patients and noted elevated anti-CCP antibodies to secondgeneration peptides in only two patients. Both patients had IgM RF-positive polyarthritis.…”

Section: Anticyclic Citrullinated Peptide Antibodiesmentioning

confidence: 98%

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Syed

Gilliam²,

Moore

2008

Curr Rheumatol Rep

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“…Meanwhile, each ACPA had a different prevalence among the JIA subtypes, mainly because of the antigens used. Anti-CCP has been extensively studied in JIA, and the sensitivity of anti-CCP has been reported to be between 1.8 and 27.9% (Machado et al, 2005;Brunner and Sitzmann, 2006;Gilliam et al, 2008;Habib et al, 2008;Kuna et al, 2009). In the present study, anti-CCP was identified in 7 (8.9%) of 81 JIA patients, agreeing with the reported rates in most published studies, and the positivity (9.9%) was slightly improved by when anti-CCP3.1 IgG and IgA were used simultaneously to detect CCP.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

et al. 2016

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ABSTRACT. The prevalence rates of anti-citrullinated protein/peptide antibodies (ACPAs) were investigated in a cohort of juvenile idiopathic arthritis (JIA) patients, and their diagnostic performances were compared. ACPAs, including anti-cyclic citrullinated peptide IgG (anti-CCP), anti-CCP IgG/IgA (anti-CCP3.1), citrullinated recombinant rat filaggrin antibodies (CPA), anti-mutated citrullinated vimentin (anti-MCV), and antibodies to citrullinated human IgG-derived peptides (RA/CP), were measured in the sera from 81 JIA patients. Serum samples from 55 children with other joint diseases or viral infections and 49 healthy donors were tested as controls. Of the 81 JIA patients, 7 (8.6%), 8 (9.9%), 17 (21.0%), 23 (28.4%), and 18 (22.2%) were found to be positive for anti-CCP, anti-CCP3.1, CPA, anti-MCV, and RA/CP, respectively, with specificities of 98.1, 95.1, 93.3, 84.6, and 86.5%. Analysis by subtype revealed that 7/7 (100%) of RF-positive polyarticular JIA patients tested positive at high serum levels for anti- MCV or RA/CP, and 5/7 (71.4%) were positive for anti-CCP, anti-CCP3.1, or CPA (P < 0.001, compared with controls). Eighteen of 81 JIA patients demonstrated joint erosions on radiographs and erosive arthritis occurred more often in ACPAs positive patients (P < 0.01). Our findings indicate that although ACPAs are not satisfactory screening biomarkers for JIA due to low sensitivity, ACPA measurement can aid in diagnosing RF-positive polyarticular JIA and identifying JIA patients with severe bone involvement. The diagnostic performance of each ACPA in JIA is different, and the careful selection of assays is necessary.

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“…But in the study by Brunner and Sitzmann [8] it was shown that these antibodies are only detected in patients with positive RF. This means that the pattern of JIA in patients with positive anti-CCP Abs resembles the RA.…”

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confidence: 94%

Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis

Ghaffarpas¹

2012

J Med Diagn Meth

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Rheumatoid Arthritis (RA) has been associated with several autoantibodies, including antiperinuclear factor, anti-keratin antibodies, anti-filaggrin antibodies, and anti-Cyclic Citrullinated Peptide (anti-CCP) antibodies. Most studies found that anti-CCP antibodies are only detected in Juvenile Rheumatoid Arthritis (JRA) patients with positive Rheumatoid Factor (RF). In our center we experimentally observed that children with Juvenile Idiopathic Arthritis (JIA) that tested positive for anti-CCP Abs were also tested positive for RF. In seven years of follow-up of these 86 patients, 63 (73.2%) developed RA. It can be hypothesized that the antibodies against CCP plays an important role in progression of the JIA towards RA. On the other hand anti-CCP Abs may play a role in the pathogenesis of RA. Further studies are needed to clarify this association.

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Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Cited by 9 publications

References 4 publications

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Diagnostic performance of anti-citrullinated protein/peptide antibodies in juvenile idiopathic arthritis

Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis

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