Anticytokine autoantibodies in chronic rhinosinusitis

Цыбиков, Н. Н.; Егорова, Э.В.; Кузник, Б. И.; Fefelova, E. V.; Magen, Eli

doi:10.2500/aap.2015.36.3880

Cited by 23 publications

(21 citation statements)

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“…The exact specificity of the antibodies detected in CRSwNP remains unclear but is the focus of ongoing investigations. Studies have provided evidence that some of the antibodies detected in CRSwNP polyps are directed against nuclear antigens and cytokines 4950 . How such autoantibodies contribute to the clinical symptoms of CRSwNP remains unclear.…”

Section: Pathophysiologymentioning

confidence: 99%

Chronic Rhinosinusitis with Nasal Polyps

Stevens

Schleimer

Kern

2016

The Journal of Allergy and Clinical Immunology: In Practice

383

314

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia and/or facial pressure or pain that last for greater than 12 weeks duration. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease.

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Section: Pathophysiologymentioning

confidence: 99%

Chronic Rhinosinusitis with Nasal Polyps

Stevens

Schleimer

Kern

2016

The Journal of Allergy and Clinical Immunology: In Practice

383

314

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“…Стресс белки обладают не только за щитными свойствами, они могут являться одними из звеньев патогенеза ринитов и риносинуситов, так как, будучи высокоим муногенными, способны индуцировать вы работку аутоантител [4,5,8].…”

Section: результаты и их обсуждениеunclassified

“…Являясь стресс лимитирующими факто рами, шапероны, или белки теплового шока (БТШ), активно синтезируются при многих патологических состояниях. Выявлено, что их концентрация в крови существенно уве личивается при хронических воспалитель ных процессах [2,8].…”

Section: Introductionunclassified

Changed content of heat shock proteins and antibodies to them in blood and nasal mucosa cells in rhinites and rhinosinusites of different etiology

et al. 2018

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Aim. To determine the content of heat shock proteins with molecular weight 70 kDa (HSP 70) and antibo dies to them in blood and nasal secretion in patients with allergic rhinites and infectious rhinosinusites of different etiology. Materials and methods. The paper presents the results of examination of 10 patients with allergic rhinitis and 30 patients, infected with rhinosinusites(the age range 25–35 years). The patients with infectious rhinosinusites were divided into 3 groups according to nosologic form of disease. The control group included 10 practically healthy persons in the ratio, comparable by their gender and age with sick persons. Results.The analysis showed that in the nasal secretion of all patients, HSP 70 level significantly raised compared to the control. Maximum values were registered in patients with bacterial rhinosinusitis and were higher than in patients with viral and fungous ones by 1.9 times (p = 0.015) and 2.9 times (p = 0.001), respectively. In blood serum, HSP 70 concentration compared with the control increased in patients with allergic rhinitis and bacterial rhinosinusitis by 103.67 % (p = 0.015) and 32.11 % (p = 0.049), respectively; these values in the last two groups exceeded the latter in patients with fungous RS by 2.37 times (p = 0.01) and by 1.54 times (p = 0.035). Conclusions. It was detected that in the group of patients with allergic rhinitis and chronic bacterial rhinosinusitis in the nasal secretion and blood serum, HSP 70 values were the highest. In the nasal secretion, HSP 70 level was higher than in blood. The amount of autoantibodies to HSP 70 in blood grew in allergic rhinitis, fungous and viral forms of rhinosinusites that reflects the immunological effect of chaperone proteins.

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“…Some of the antibodies found in CRSwNP nasal polyps are against self-proteins (e.g. nuclear antigens and cytokines) but it is unclear if similar levels of autoantibodies exist in AERD patients 58, 59 .…”

Section: Disease Pathophysiologymentioning

confidence: 99%

Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis

Stevens

Schleimer

2016

Immunology and Allergy Clinics of North America

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Synopsis Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both diseases characterized by the presence of chronic sinonasal inflammation and nasal polyps. Both diseases are associated with asthma; AERD by definition and CRSwNP by common comorbidity (~50%). Therefore, the most prominent clinical feature distinguishing patients with AERD from those with CRSwNP remains the development of an upper or lower respiratory tract reaction following the ingestion of a COX-1 inhibitor. However, even in the absence of COX-1 inhibitors, there are other notable clinical and pathophysiological differences between AERD and CRSwNP patients. Patients with AERD on average have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to patients with CRSwNP. While no single genetic factor has been identified in either CRSwNP or AERD pathogenesis to date, many studies have evaluated whether there are differences in the underlying cellular and molecular mechanisms that account for the observed clinical variations. Studies from several laboratories have discovered important differences in the metabolism of arachidonic acid, including increased activity of the 5-lipoxygenase pathway and decreased levels of the anti-inflammatory prostanoid PGE2. Clear evidence for activation of platelets in AERD also distinguishes it from CRSwNP. Nasal polyp tissues from both AERD and CRSwNP are characterized by type-2 inflammation but there are significantly increased levels of eosinophil and mast cell degranulation products in AERD sinonasal tissue, and recent evidence suggesting that spontaneous activation of eosinophils, basophils and mast cells occurs.

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Anticytokine autoantibodies in chronic rhinosinusitis

Abstract: In patients with CRS, IgA class AAbs were detected in NS, whereas the highest levels of anti-IL-5 and anti-IL-17A AAbs were detected in patients with CRSwNP. Maybe these AAbs indicate disruption of immune tolerance and mucosal autoimmunity.

Cited by 23 publications

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Chronic Rhinosinusitis with Nasal Polyps

Chronic Rhinosinusitis with Nasal Polyps

Changed content of heat shock proteins and antibodies to them in blood and nasal mucosa cells in rhinites and rhinosinusites of different etiology

Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis

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