Antidementia Effects of Alternanthera philoxeroides in Ovariectomized Mice Supported by NMR-Based Metabolomic Analysis

Khamphukdee, Charinya; Monthakantirat, Orawan; Chulikhit, Yaowared; Boonyarat, Chantana; Daodee, Supawadee; Aon-Im, Possatorn; Maneenet, Juthamart; Chotritthirong, Yutthana; Luecha, Prathan; Şekeroğlu, Nazım; Kijjoa, Anake

doi:10.3390/molecules26092789

Cited by 6 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They had noticed various mechanisms behind it like inhibition of lipid peroxidation in the whole brain, downregulation of neuroinflammatory cytokines (IL-1β, IL-6, and TNF-α), etc ( Khamphukdee et al, 2021 ). Phytomolecules like Luteolin and luteolin analogs ( Delgado et al, 2021 ), Vitexin ( Malar et al, 2020 ; Zhang et al, 2021 ), Quercetin ( Yao et al, 2010 ), Torosaflavone E ( Khamphukdee et al, 2021 ), Demethyl torosaflavone D ( Khamphukdee et al, 2021 ), β-Sitosterol ( Kim et al, 2008 ), Stigmasterol ( Park S. J. et al, 2012 ; Pratiwi et al, 2021 ), Ursolic acid ( Habtemariam, 2019 ), Oleanolic acid and oleanolic acid analogs ( Lin et al, 2021 ), Caffeic acid ( Khan et al, 2013 ; Deshmukh et al, 2016 ), Quinic acid ( Liu et al, 2020 ), p-Coumaric acid ( Kim H.-B. et al, 2017 ), β-Carboline ( Zhao et al, 2013 ; Li et al, 2018 ), Malic acid ( Tian et al, 2021 ), Blumenol A ( Emir et al, 2019 ), Phytol ( Sathya et al, 2020 ), and Pheophytin A ( Park et al, 2014 ) which were earlier reported from Alternanthera philoxeroides (Mart.)…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

View full text Add to dashboard Cite

Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

show abstract

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Previous works from different groups have shown that OVX induces neuroinflammation (overproduction of inflammatory cytokines and glial activation in CNS) and/or memory decline, depression-like behaviors in mice, [45][46][47][48][49][50][51][52][53] and in rats. [54][55][56][57][58] Consistently, in the present work we found that chronic pain and memory/emotional deficits were associated with neuroinflammation in OVX and aged female mice.…”

Section: Discussionmentioning

confidence: 99%

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

Zhang¹,

Xiong²,

Lin³

et al. 2021

JIR

View full text Add to dashboard Cite

Postmenopausal women often suffer from chronic pain, memory decline and mood depression. The mechanisms underlying the neuronal disorders are not fully understood, and effective treatment is still lacking. Methods: Oral administration of magnesium-L-threonate was tested to treat the neuronal disorders in ovariectomized and aged female mice. The pain hypersensitivity, memory function and depression-like behaviors were measured with a set of behavioral tests. Western blots, immunochemistry and in situ hybridization were used to assess molecular changes. Results: Chronic oral administration of magnesium-L-threonate substantially prevented or reversed the chronic pain and memory/emotional deficits in both ovariectomized and aged female mice. We found that phospho-p65, an active form of nuclear factor-kappaB, tumor necrosis factoralpha and interleukin-1 beta were significantly upregulated in the neurons of dorsal root ganglion, spinal dorsal horn and hippocampus in ovariectomized and aged mice. The microglia and astrocytes were activated in spinal dorsal horn and hippocampus. Calcitonin gene-related peptide, a marker for peptidergic C-fibers, was upregulated in dorsal horn, which is associated with potentiation of C-fiber-mediated synaptic transmission in the model mice. In parallel with neuroinflammation and synaptic potentiation, free Mg 2+ levels in plasma, cerebrospinal fluid and in dorsal root ganglion neurons were significantly reduced. Oral magnesium-L-threonate normalized the neuroinflammation, synaptic potentiation and Mg 2+ deficiency, but did not affect the estrogen decline in ovariectomized and aged mice. Furthermore, in cultured dorsal root ganglion neurons, estrogen at physiological concentration elevated intracellular Mg 2+ , and downregulated phospho-p65, tumor necrosis factor-alpha and interleukin-1 beta exclusively in the presence of extracellular Mg 2+ . Conclusion: Estrogen decline in menopause may cause neuroinflammation by reducing intracellular Mg 2+ in neurons, leading to chronic pain, memory/emotional deficits. Supplement Mg 2+ by oral magnesium-L-threonate may be a novel approach for treating menopause-related neuronal disorders.

show abstract

“…Although A. philoxeroides is considered as an obnoxious invasive weed around the globe, because of its long-standing traditional medicinal uses, particularly against various viral infectious diseases, this plant and its secondary metabolites have been subjected to various bioactivity studies, revealing the therapeutic potential of this species [2][3][4][5][6][7][8][9][10][11][12][13][16][17][18]29,43,44,[72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91], particularly as an antiviral agent (Table 1).…”

Section: Bioactivities and Therapeutic Potential As An Antiviral Agentmentioning

confidence: 99%

“…Several plant products (e.g., Ginkgo biloba extract, ginseng extract, coconut oil, omega-3 fatty acids, curcumin, and resveratrol, and vitamins (e.g., vitamin B 12 and vitamin D) have long been used for the prevention and treatment of dementia [77]. Khamphukdee et al [78] recently evaluated an EtOH extract of the whole plant of A. philoxeroides for its potential in the treatment of dementia, using various assays including in vitro antioxidant assays, β-amyloid aggregation inhibition, and cholinesterase inhibitory activity assays as well as an in vivo Morris water maze task, novel object recognition task, and Y-maze task assays. The extract as well as its flavonoids (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) offered inhibition of β-amyloid aggregation.…”

Section: Antidementia Activitymentioning

confidence: 99%

“…At least four different reports are available on the antioxidant property of A. philoxeroides [6,15,18,78]. The phytochemical profile that we know from the published literature about this species could easily support its antioxidant activity, as this plant is rich in natural antioxidants, ascorbic acid, anthraquinones, flavonoids, and other phenolics [4][5][6][10][11][12]76].…”

Section: Antioxidant Activitymentioning

confidence: 99%

See 1 more Smart Citation

“Malancha” [Alternanthera philoxeroides (Mart.) Griseb.]: A Potential Therapeutic Option against Viral Diseases

2022

View full text Add to dashboard Cite

Alternanthera philoxeroides (Mart.) Griseb., commonly known as “Alligator weed” in English, and “Malancha” in Bengali, is a leafy vegetable from the family Amaranthaceae A. L. de Jussieu. This species is native to China, particularly to the provinces around the Yangtze River, other Far East and South-East Asian countries, and countries from other continents (e.g., South America). This plant also grows in certain areas in Australia, New Zealand, and the USA. While in Bangladesh the leaves of this plant are consumed as a vegetable, in China, this plant has been used widely as a traditional remedy for the treatment of various viral diseases (e.g., measles, influenza, and haemorrhagic fever). Flavonoids and saponins are the two largest groups of phytochemicals produced by this plant, and the antiviral property of this plant and its compounds has been studied extensively. This review article reviews all published literature on this plant and critically appraises its phytochemical profile linking to biomolecular interactions and therapeutic potential, particularly, against viral diseases.

show abstract

Antidementia Effects of Alternanthera philoxeroides in Ovariectomized Mice Supported by NMR-Based Metabolomic Analysis

Cited by 6 publications

References 39 publications

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

“Malancha” [Alternanthera philoxeroides (Mart.) Griseb.]: A Potential Therapeutic Option against Viral Diseases

Contact Info

Product

Resources

About