Antidepressant activity of methyl jasmonate, a plant stress hormone in mice

Umukoro, Solomon; Alabi, Akinyinka

doi:10.1016/j.pbb.2010.12.001

Cited by 23 publications

(28 citation statements)

References 29 publications

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Section: Biological Activities Of Ja Derivativesmentioning

confidence: 85%

“…The possibility that sufficient amounts of MJ enter the brain through the blood–brain barrier to exert behavioral effects has been reported in previous studies . MJ has been shown to demonstrate antidepressant properties based on its ability to reduce the period of immobility in the forced swim and tail suspension tests in mice . Umukoro et al also reported that the mechanism of effects of MJ as antidepressant could involve the facilitation of both serotonergic and noradrenergic neurotransmission.…”

Section: Biological Activities Of Ja Derivativesmentioning

confidence: 86%

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A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

Pirbalouti

Sajjadi

Parang

2014

Archiv der Pharmazie

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In medicinal chemistry there is a growing interest in using small molecules, including plant stress hormones. Jasmonic acid (JA) and its volatile methyl ester (MJ), collectively termed jasmonates, are lipid‐derived cyclopentanone compounds that occur ubiquitously and exclusively in the plant kingdom. This review covers the synthesis, usage, and biological activities of JA and its derivatives. A brief overview of the available information on JA and its features is given, followed by a detailed review of JA and its derivatives as drugs and prodrugs; the properties in plants and the synthesis in recent patents are described. This review shows the direction of long‐term drug/nutraceutical safety trials and provides insights for future research in this area. Research on JA continues to be of major interest. Recent innovations offer hope for the development of new therapeutics in related fields. It is anticipated that several analogs can be advanced to preclinical and clinical studies.

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Section: Biological Activities Of Ja Derivativesmentioning

confidence: 85%

Section: Biological Activities Of Ja Derivativesmentioning

confidence: 86%

A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

Pirbalouti

Sajjadi

Parang

2014

Archiv der Pharmazie

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“…MJ was prepared as previously described [Umukoro et al, ). Briefly, 0.5 mL of MJ was dissolved in 4.5 mL of ethanol (95%) to obtain a stock solution, which was further diluted with distilled water to attain the various doses used in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, MJ demonstrated adaptogenic, antiamnesic, and antipsychotic activities in rodents [Eduviere et al, ; Umukoro et al, ; Annafi et al, ] and exhibited antidepressant‐like activity in mice subjected to acute stress models of forced swimming (FST) and tail suspension (TST) tests. It also attenuated depressive‐like symptoms induced by lipopolysaccharide in mice [Umukoro et al, ; Adebesin et al, ]. However, no studies have been carried out to assess the effect of MJ on UCMS‐induced depression‐like behavior, which reflects the clinical depressive illnesses seen in humans [Willner et al, ; Farooq, ; Chakravarty et al, ; Zhu et al, ].…”

Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain

Adebesin

Ajayi

Olonode

et al. 2017

Drug Development Research

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Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant-like activity. MJ also reduced UCMS-induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS-induced decreases in GSH and TNF-α levels and SOD activity. These findings suggest that MJ attenuated UCMS-induced depressive-like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381-389, 2017. © 2017 Wiley Periodicals, Inc.

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“…During the last decade, natural or alternative medicines to treat depression are becoming more prevalent. In particular, many traditional Chinese medicines (TCM) such as valerian, areca seed, as well as some TCM complex prescriptions have received a great amount of attention (Hattesohl et al, 2008;Umukoro et al, 2011).…”

Section: Discussionmentioning

confidence: 99%