Antidepressant activity of some phytopharmaceuticals and phenylpropanoids

Abstract

The antidepressant activity of some phytopreparations and phenylpropanoids was studied in white rats, which were subjected to the desperation test and neuropharmacological tests based on the antagonist activity with respect to reserpine, clofelin, and L-DOPA. The most pronounced effect was exhibited by the extract of Eleutherococcus senticosus, which produced a 56.4% decrease in the immobilization period in rats that was comparable with, albeit somewhat lower than the effect of amitriptyline (73.5%). The antidepressant effects of other phytopreparations decreased in the following order: Rhodiola rosea (53.8%), Echinacea purpurea (49%), and Schizandra chinensis (29.8%). Among phenylpropanoids, the maximum antidepressant effects were produced by syringin and rosavin (49.7% and 29.5%, respectively). The most pronounced antagonism with respect to reserpine was also observed for syringin. The tinctures of Echinacea purpurea and Schizandra chinensis, as well as phenylpropanoid triandrin produced the maximum antidepressant effect in the clofelin-induced depression test. An increase in the stimulating action of L-DOPA was observed upon the administration of rosavin and the tinctures of Schizandra chinensis and Echinacea purpurea.

Monoamine oxidase inhibition by Rhodiola rosea L. roots

“…The phenylpropanoid glycosides rosin (11), rosarin (5), and rosavin (9) have been described in the literature as the molecules responsible for the antidepressant activity (Zapesochnaya et al, 1995;Kurkin et al, 2006). Furthermore, Russian researchers have chosen rosavin as a marker compound.…”

“…Although many studies have provided evidence that administration of Rhodiola rosea extract elicits antidepressant activity (Kurkin et al, 2006;Darbinyan et al, 2007;Perfumi and Mattioli, 2007;Panossian et al, 2008), the mechanism of action of Rhodiola rosea in the treatment of nervous system disorders still remains unclear.…”

Effect of phytopreparations containing phenylpropanoids on the physical activity of animals

“…The doses of plant extracts were chosen on a level that was previously established to be optimum for the investigation of neurotropic activity [28]. Experiments showed (Table 1) that all phytopreparations studied (except for Saint Mary thistle liquid extract) increase the exercise performance (work capacity) of test mice as compared to those in the control group.…”

Aromatic Compounds and Soluble Carbohydrate Profiles of Different Varieties of Tunisian Raisin (Vitis ViniferaL.)

“…The phenylpropanoids pathway, an important source of metabolites in plants, is required for the biosynthesis of lignin and serves as a starting point for the production of many other important compounds, including flavonoids, coumarins and lignans. [28] Furthermore, diverse physiological and pharmacological properties of these natural compounds, including antioxidant, anti-inflammatory and antinociceptive, [33] hypoglycemic and antidepressant effects [35] and antitumor activity [36] have been reported. A c c e p t e d M a n u s c r i p t 10 determined enzyme composition of the fruit.…”