Monoamine oxidase inhibition by Rhodiola rosea L. roots

Diermen, Daphne van; Marston, Andrew; Bravo, Juan; Reist, Marianne; Carrupt, Pierre‐Alain; Hostettmann, Kurt

doi:10.1016/j.jep.2009.01.007

Cited by 172 publications

(105 citation statements)

References 29 publications

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“…Among the various substances that golden root contains, p-tyrosol, salidroside, rosavins, and additional phenolic compounds are thought to be responsible for its adaptogenic properties (Ming et al, 2005). It is thought to inhibit monoamine oxidase and catechol-O-methyltransferase (Van Diermen et al, 2009). It may also exert activity on the opioid system.…”

Section: Golden Root (Rhodiola Rosea)mentioning

confidence: 99%

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Baek

Nierenberg

Kinrys

2014

Aust N Z J Psychiatry

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Objectives: Patients with bipolar disorder frequently continue to experience residual anxiety and insomnia between mood episodes. In real-world practice, patients increasingly self-prescribe alternative medicines. Methods:We reviewed case reports, open-label, and placebo-controlled trials investigating the use of herbal medicines to treat anxiety and insomnia, and discussed their potential applications for bipolar disorder.Results: Eleven herbal medicines that have been studied in human subjects are included in this review. Mechanisms of action, efficacy, side effects, and drug-drug interactions are discussed. Based on currently available evidence, valerian seems to be the most promising candidate for insomnia and anxiety in bipolar disorder. Conclusions:Adjunctive herbal medicines may have the potential to alleviate these symptoms and improve the outcomes of standard treatment, despite limited evidence. Physicians need to have a more in-depth understanding of the evidence of benefits, risks, and drug interactions of alternative treatments.

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Section: Golden Root (Rhodiola Rosea)mentioning

confidence: 99%

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Baek

Nierenberg

Kinrys

2014

Aust N Z J Psychiatry

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“…Moreover, it has been demonstrated that rosiridin interfered with the degradation of the norepinephrine, that regulates the activity of the hormone-sensitive lipase (HSL) in breaking down fat stored in adipose tissue, by inhibiting the action of monoamine oxidases (MAOs) [42].…”

Section: Editorialmentioning

confidence: 99%

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

Colitti¹

2014

Endocrinol Metab Syndr

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EditorialMany natural phytonutrients have beneficial effects on health [1,2]. In addition, several botanicals have received positive attention, based on their relative safety and the accumulation of evidence of their antiadipogenic and metabolic effects in animals and humans [3]. Natural products can decrease of lipid absorption, energy intake, lipogenesis, pre-adipocyte differentiation and proliferation or increase of energy expenditure, and lipolysis [4]. These properties exist in specific flavonoids [5], chlorogenic acid from green coffee bean [6], and carnosic acid in rosemary [7]. Extracts from Rhodiola rosea (RR) root is poorly characterized for its properties on adipocytes and only recently it has been proposed for a the adjuvant treatment of obesity against obesity [8].RR is a popular plant in traditional medical systems in the Nordic countries, Eastern Europe and Asia. It belongs to the family of Crassulaceae with a notoriety for stimulating physical endurance, attention span, memory, and work productivity [9][10][11]. The genus Rhodiola contains more than 100 different species, and at least 20 of these are used in traditional Asian medicine [12,13]. However, the most of all animal and human studies has been conducted on RR, so whether other species confer the same health benefits is unknown [14,15].Researches on the RR root phytochemistry has revealed the presence of six distinct groups of chemical compounds: phenylpropanoids (rosavin, rosin, rosarin), phenylethanol derivatives (salidroside, tyrosol); flavonoids (rodiolin, rodionin, rodiosin, acetylrodalgin, tricin), monoterpernes (rosiridol, rosaridin), triterpenes (daucosterol, beta-sitosterol) and phenolic acids (chlorogenic and hydroxycinnamic, gallic acids) [9,16].According to the Soviet Pharmacopeia [17,18], the extracts of RRprimarily in the form of water/alcohol tinctures or dried root extractare standardized for both rosavins and salidroside. RR extracts used in most human clinical studies were standardized to minimum 3% rosavins and 0.8-1% salidroside, because the naturally occurring ratio of these compounds in RR root is approximately 3:1 [14].The main effects of genus Rhodiola described are adaptogenic that means 'natural herbal products which are non-toxic in normal doses, produce a non-specific response, and have a normalizing physiologic influence' and stress protective [19,20]. Moreover, Rhodiola has been described as antioxidant [21][22][23] [32,33], and immunostimulating [34][35][36]. Recently, many other benefits from the use of RR has been found including its ability to regulate blood sugar levels for diabetics and to activate the lipolytic processes [37], mobilizing lipids from adipose tissue to the natural fat burning system of body for weight reduction [8]. In combination with Citrus aurantium, RR has been found to decrease visceral fat weight by 30% of rats fed with high fat diet, having a direct effect on sympathetic tone and on hypothalamic norepinephrine secretion [8]. Although detailed molecular mechanism of the lipid loweri...

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“…R. rosea is used in traditional Chinese medicine in the treatment of nervous system, improvement of sleep and for cardioprotective characteristics [7,[9][10][11][12][13]. The roots enhance physical and mental performance, treats fatigue and depression [7,[10][11][12]14].…”

Section: Introductionmentioning

confidence: 99%

Novel method of detection of phenylpropanoids of Rhodiola roots species

et al. 2013

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S u m m a r yThe aim of the study was the identification and quantitative analysis of phenylpropanoid compounds in the roots of Rhodiola species. Rosavin, rosarin and rosin were determined in the roots of R. kirilowii and R. rosea from the field cultivation, Institute of Natural Fibres and Medicinal Plants. For the quantitative analysis, the ultra performance liquid chromatography -tandem mass spectrometry (UPLC-ESI MS/MS, Waters) was used. The results showed differences in the quantitative and qualitative assessments of these two species. In the root of R. kirilowii the presence of phenylpropanoids was not confirmed. In R. rosea the most common phenylpropanoid was rosavin (0.022%). The UPLC-MS/MS studies allowed to use this analytical method for determination of phenylpropanoids in the accordance with the requirements of ICH.

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Monoamine oxidase inhibition by Rhodiola rosea L. roots

Cited by 172 publications

References 29 publications

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

Novel method of detection of phenylpropanoids of Rhodiola roots species

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