2013
DOI: 10.1177/039463201302600110
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Antidepressant Drug, Desipramine, Alleviates Allergic Rhinitis by Regulating Treg and Th 17 Cells

Abstract: The first two authors contributed equally to this work Allergic rhinitis (AR) is characterized by IgE-mediated immediate hypersensitivity and usually progresses to chronic nasal inflammation, with depression as one of its comorbidities. The importance of treating the depression in AR patients has been increasingly recognized. Desipramine is a representative of tricyclic-antidepressant agents. In the present study we investigate whether desipramine has therapeutic effects on AR inflammation. BALB/C mice were se… Show more

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Cited by 34 publications
(31 citation statements)
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“…Himmerich et al (2010) described a similar increase in T reg cells in a naturalistic study of antidepressant treatment in 16 MDD patients. Moreover, desipramine treatment increased T reg cells in a mouse model of allergic rhinitis (Zhang et al 2013). It is thus possible that antidepressants, and in particular tricyclic antidepressants, facilitate the normalization of inflammatory activation in MDD patients by increasing the T reg cell population.…”
Section: Discussionmentioning
confidence: 99%
“…Himmerich et al (2010) described a similar increase in T reg cells in a naturalistic study of antidepressant treatment in 16 MDD patients. Moreover, desipramine treatment increased T reg cells in a mouse model of allergic rhinitis (Zhang et al 2013). It is thus possible that antidepressants, and in particular tricyclic antidepressants, facilitate the normalization of inflammatory activation in MDD patients by increasing the T reg cell population.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, individuals with inflammatory diseases are three to four times more likely to experience depression [69, 99, 103, 254, 441]. Moreover, although low-dose intravenous injection of Salmonella abortus equi endotoxin (0.8 ng/kg body weight) had no effects on physical sickness symptoms, blood pressure or heart rate, elevation of circulating cytokine levels (TNF, soluble TNF receptors, IL-6, IL-1 receptor antagonist) was positively correlated with endotoxin-induced anxiety levels and depressed mood and negatively correlated with verbal and non-verbal memory functions [339].…”
Section: Stress Inflammation and Mental Health: The Cytokine Theorymentioning
confidence: 99%
“…Generation of IL-10-producing Tregs may be a prominent mechanism underlying these findings (15). The antidepressant drug desipramine appears to alleviate allergic rhinitis by regulating Tregs and Th17 cells (120). Although clinical trials have not attempted adoptive transfer of Tregs for allergic disease, protocols to expand allergen-specific Tregs may potentially benefit atopic patients.…”
Section: Examples Of Treg Immunotherapymentioning
confidence: 99%