Antidepressant drugs and memory: Insights from animal studies

Monleón, Santiago; Vinader‐Caerols, Concepción; Arenas, M. Carmen; Parra, Andrés

doi:10.1016/j.euroneuro.2007.07.001

Cited by 45 publications

(30 citation statements)

References 139 publications

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“…Here, the schedule treatment (pre-training versus post-training) and doses used have been suggested to be determinant (Monleon et al 2008). We have addressed this by testing a wide dose range of escitalopram using different schedule treatments.…”

Section: Discussionmentioning

confidence: 98%

The effects of acute treatment with escitalopram on the different stages of contextual fear conditioning are reversed by atomoxetine

et al. 2010

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Section: Discussionmentioning

confidence: 98%

The effects of acute treatment with escitalopram on the different stages of contextual fear conditioning are reversed by atomoxetine

et al. 2010

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“…There are reports in the literature that pre-training administration of acute high doses (40 mg/kg) of clomipramine have detrimental effects on IA learning in mice, whilst chronic administration of lower doses (15 mg/kg) improves this kind of learning in rats (see Monleón et al 2008). In the present study, chronic administration of clomipramine (10 mg/kg) did not have a significant effect when administered to non-stressed animals, but it counteracted the adverse effects of CSDS on memory when administered to defeated animals.…”

Section: Discussionmentioning

confidence: 99%

Effects of social stress and clomipramine on emotional memory in mice

Duque¹,

Vinader‐Caerols²,

Monleón³

2016

Acta Neurobiologiae Experimentalis

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We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study.Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed+saline and stressed+clomipramine. Stressed animals were subjected to daily agonistic encounters (10 min) in the home cage of the aggressor over a 20-day period. Just before each encounter, non-stressed and stressed mice were injected i.p. with saline or clomipramine (10 mg/kg) according to their experimental condition. 24 hours after the last CSDS session, all the mice were tested in a step-through IA task. In the IA training phase, animals were punished by a shock to the paw when they entered the dark compartment of the apparatus. In the IA test phase (one week later) the same procedure took place, but without shock. Complementary measures were obtained by evaluating all the animals in an elevated plus maze (locomotor activity and emotionality) and on a hot plate (analgesia). IA learning was confirmed in all groups except the stressed+saline group, which was the only one that exhibited higher anxiety levels. No variations were observed in either locomotor activity or analgesia. In conclusion, CSDS induces anxiety and impairs emotional memory in mice; the negative effects of CSDS on memory appear to be attenuated by clomipramine, and these detrimental effects do not seem to be secondary to the effects of CSDS on locomotor activity, emotionality or pain sensitivity.

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“…inhibitors (MAOIs). Some of these drugs, however, have undesirable side effects (Park et al, 2005;Monleon et al, 2008). Herbal therapies may be effective alternatives in the treatment of depression and the search for novel pharmacotherapy from medicinal plants for psychiatric illnesses, including depression, has progressed significantly in the past decade (Zhang, 2004).…”

Section: Introductionmentioning

confidence: 99%