Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse

Zhou, Xiaojiang; Liu, Ming; Yan, Jing; Cao, Yin; Liu, Ping

doi:10.1016/j.jep.2011.11.027

Cited by 54 publications

(39 citation statements)

References 32 publications

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“…Previous studies confirm that KXS shows positive effect in enhancing memory or alleviating depression-like symptoms on animal models 20–25 . As to its action mechanism, most of research articles focus on regulation of monoamine neurotransmitter and stress hormone system 16, 17, 26, 27 , while only a few paper on neurotrophin system 18, 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Until now, KXS is still applied for the treatment of depression in clinic and has been reported to relieve the depressive symptoms of major depression disorder patients, as also revealed in animal studies 14, 15 . For exploration of the action mechanism of KXS, most of the researches focus on neurotransmitter regulation 16, 17 while the effect on neurotrophin regulation is seldom explored 18 .…”

Section: Introductionmentioning

confidence: 99%

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Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Zhu¹,

Chao²,

Duan³

et al. 2017

Sci Rep

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Kai-xin-san (KXS) is a famous Chinese medicinal formula applied for treating stress-related psychiatric diseases with the symptoms such as depression, forgetfulness and dizziness. In clinic, the composition ratio of KXS is always varied and KXS series formulae are created. Here, we aim to compare the anti-depressive effect of different ratios of KXS and reveal its action mechanism on regulation of neurotrophic factor system. Firstly, daily intra-gastric administration of chemically standardized extracts of KXS series formulae for seven days significantly alleviated the depressive symptoms of chronic unpredictable mild stressed mice displayed by enhanced sucrose consumptions and decreased immobile time of forced swimming coupled with increased locomotor activities. KXS might fulfill this effect by up-regulating the expressions of NGF, BDNF and Trk receptors in hippocampus, which were confirmed by the treatment of corresponding blockers tPA-stop and K252a. The ratio with higher amounts of Ginseng Radix et Rhizoma and Polygalae Radix exerted most profound effect on anti-depression and regulation enzymes in metabolic pathway of neurotrophic factors. These findings suggested that KXS was beneficial for enhancing supplies, up-regulating receptors, and restoring the dysfunction of metabolic pathway of neurotrophic factors, which might account for its anti-depression effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Zhu¹,

Chao²,

Duan³

et al. 2017

Sci Rep

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show abstract

“…Mice become hypothermic, akinetic, and diarrhetic, with eyelid drooping, in response to reserpine. Reserpine irreversibly inhibits the vesicular uptake of monoamine neurotransmitters such as NA, DA, and 5-HT (13)(14)(15)(16)(17). The symptoms are reversed by major classes of antidepressant drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Brain levels of NE, DA, 5-HT, and the 5-HT metabolite 5-HIAA were measured with ELISA kits according to the manufacturer's protocols (14)(15)(16). The levels of NE, DA, 5-HT, and 5-HIAA were expressed as ng/ g in wet weight tissue.…”

Section: Measurement Of Monoamine Neurotransmitter Levelsmentioning

confidence: 99%

Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

Wang

Cui

Feng

et al. 2014

BST

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“…However, in some reports, KXS is all the same as DZXW, which is owing to a lack of printing technologies in Tang dynasty, the original edition of "Bei-Ji-Qian-Jin-YaoFang" (652 A.D.) has never been seen. [4,5] Nowadays, more pharmacological studies for DZXW have been carried out. The results have demonstrated that DZXW could restore 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stressinduced depressive rats, [6] and ameliorate chronic fatigue syndrome mice.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Identification of the Chemical Constituents of Ding‐Zhi‐Xiao‐Wan Prescription by HPLC‐IT‐MSⁿ and HPLC‐Q‐TOF‐MS

Tang

Liu

et al. 2015

Chin. J. Chem.

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Ding-Zhi-Xiao-Wan (DZXW) is a famous traditional Chinese medicine (TCM) formula, which is composed of four herbs, Ginseng Radix, Poria, Polygala Radix and Acori Tatarinowii Rhizoma. It has been popularly used for the treatment of emotional disease, like Alzheimer's disease, Parkinson's disease, depression, anxiety, forgetfulness and neurasthenia. In this research, a high-performance liquid chromatography coupled with ion-trap tandem mass spectrometry (HPLC-IT-MS n ) method along with a high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method in negative ion mode was established to investigate the major constitutions in DZXW. The extracts were prepared by ultra-sonication in ethyl acetate, n-butanol, 95% ethanol and deionized water sequentially as well as in deionized water directly. A Kromasil C18 column was used to separate the extracts of DZXW. Acetonitrile and 0.1% aqueous formic acid (V/V) were used as the mobile phase. A total of 64 components were characterized, including 16 triterpenoids, 14 Polygala saponins, 10 oligosaccharide esters, 6 sucrose esters, 2 xanthone C-glycosides and 16 ginsenosides.

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Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse

Cited by 54 publications

References 32 publications

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

Analysis and Identification of the Chemical Constituents of Ding‐Zhi‐Xiao‐Wan Prescription by HPLC‐IT‐MSⁿ and HPLC‐Q‐TOF‐MS

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Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse

Cited by 54 publications

References 32 publications

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

Analysis and Identification of the Chemical Constituents of Ding‐Zhi‐Xiao‐Wan Prescription by HPLC‐IT‐MSn and HPLC‐Q‐TOF‐MS

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Product

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About

Analysis and Identification of the Chemical Constituents of Ding‐Zhi‐Xiao‐Wan Prescription by HPLC‐IT‐MSⁿ and HPLC‐Q‐TOF‐MS