Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

Wang, Junming; Cui, Ying; Feng, Weisheng; Zhang, Yueyue; Wang, Guifang; Wang, Xingxing; Zhou, Gai

doi:10.5582/bst.2014.01029

Cited by 25 publications

(15 citation statements)

References 14 publications

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“…Reserpine can inhibit the vesicular uptake of monoamines and interfere with the storage of monoamines such as noradrenaline, DA, and 5‐HT. As a consequence, hypothermia and eyelid drooping are observed as the depletion of monoamines stores in response to reserpine . In the present study, OEO‐treated animals antagonized reserpine‐induced hypothermia and palpebral ptosis, but it was statistically insignificant compared with the reserpine‐treated animals.…”

Section: Discussioncontrasting

confidence: 51%

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

Zhang

Yang

Ren

et al. 2019

Flavour & Fragrance J

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This study was intended to examine the effects of navel orange (Citrus sinensis (L.) Osbeck) essential oil (OEO) on depression in the reserpine‐treated mice. And the chemical composition of OEO was analysed by gas chromatography (GC) analysis. The results indicated that the major compounds of OEO were terpenes. And OEO treatment produced an antidepressant‐like effect in mice, as indicated by the increased locomotor activity in the open field test (OFT) and attenuated dyslipidemia, but it had no effect on duration of immobility in the forced swim test (FST). Dietary OEO counteracted the reserpine‐induced hypothermia and palpebral ptosis. Moreover, OEO treatment increased the levels of serotonin (5‐HT) and dopamine (DA) in the mice brain. These antidepressant‐like effects of OEO are essentially similar to the effects of the antidepressant fluoxetine. And the action of OEO may be mediated by the central serotonergic and dopaminergic systems.

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Section: Discussioncontrasting

confidence: 51%

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

Zhang

Yang

Ren

et al. 2019

Flavour & Fragrance J

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“…Sucrose preference was calculated as sucrose preference (%) = sucrose intake (mL) / [sucrose intake (mL) + water intake (mL)] × 100%. The treatment protocol of doses and administration route used for catalpol and FH were adopted as described in previous studies [30,39].…”

Section: Sucrose Preference and Drug Administrationsmentioning

confidence: 99%

“…Catalpol, a major bioactive compound enriched by the dried root of R. glutinosa with the chemical structure previously shown [30], has been found to demonstrate broad and diverse bioactivities including neuroprotection, ameliorating cognition deficits and diabetic encephalopathy, potentially attenuating inflammation-related neurodegenerative diseases, protection against cerebral and cardiac ischemia/reperfusion injury, hepatoprotection, and radioprotection [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 98%

“…Previous studies also indicated that the ethanol extracts of R. glutinosa and catalpol reduced the immobility time during forced swim and tail suspension tests in mice [30,39], suggesting that catalpol causes an antidepressant-like effect by regulating the central monoaminergic system. As mentioned above, BDNF and COX-2 play important roles in the pathogenesis of depression, and catalpol has already been known to stimulate BDNF and inhibit COX-2 in multiple disease models [40][41][42][43][44].…”

Section: Introductionmentioning

confidence: 98%

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BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang

Yang

Zhang

et al. 2015

Physiology & Behavior

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“…43 Fluoxetine also increases the levels of brain NE and its action was mediated by the central noradrenergic systems. 44 Proinflammatory cytokines play an important role in monoamine metabolism in mice and rats. 45,46 Therefore, we suggest that monoamines, BDNF, and proinflammatory cytokines regulations become potential targets of therapy for depression.…”

Section: 26mentioning

confidence: 99%

Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test

Jeong

Yang

Kim

et al. 2016

Exp Biol Med (Maywood)

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Depression is usually accompanied by neuro-inflammatory reactions. Chelidonic acid, in particular, has shown anti-inflammatory effects. The objective of this study was to evaluate the anti-depressant effects of chelidonic acid and to discuss the potential mechanisms of a forced swimming test. Chelidonic acid was administered orally once a day for 14 days. On the 14th day, chelidonic acid resulted in a significant decrease in immobility time during the forced swimming test without alteration of locomotor activity, in an open field test. Chelidonic acid also increased the number of nissl bodies in the hippocampus. Brain-derived neurotrophic factor expression and extracellular signal-regulated protein kinase phosphorylation in the hippocampus were up-regulated by the administration of chelidonic acid. Chelidonic acid administration significantly increased the mRNA expression of hippocampal estrogen receptor-b. The levels of hippocampal interleukin (IL)-1b, IL-6, and tumor necrosis factor-a were effectively attenuated by the administration of chelidonic acid. In addition, chelidonic acid significantly increased the levels of 5-hydroxytryptamine (serotonin), dopamine, and norepinephrine compared with those levels for the mice that were administered distilled water in the hippocampus. These results suggest that chelidonic acid might serve as a new therapeutic strategy for the regulation of depression associated with inflammation.

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Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

Cited by 25 publications

References 14 publications

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test

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