Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.

Butterweck, Veronika; Nishibe, Sansei; Sasaki, Tsutomu; Uchida, Masataka

doi:10.1248/bpb.24.848

Cited by 96 publications

(80 citation statements)

References 10 publications

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“…Figure 1 shows the effects of imipramine and LAE on the immobility time in the FST. The mean immobility time and SEM in rats treated with imipramine was 154 ± 16 s, which was significantly lower (t = 3.13, df = 12, p = 0.009) than that of the vehicle control rats (236 ± 21 s), indicating that the test had sufficient sensitivity to detect antidepressant-like action of the positive control drug at a dose previously reported to be effective in the FST in rats (Butterweck et al, 2001). On the other hand, the immobility time in rats treated with LAE at the low, medium, and high doses was 242 ± 18, 234 ± 12, and 178 ± 23 s, respectively, indicating a dose-dependent reduction of immobility time.…”

Section: Resultsmentioning

confidence: 72%

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Kageyama

Ueno²,

Oshio

et al. 2012

FSTR

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The purpose of the present study was to examine the antidepressant-like effects of an aqueous extract of lavender (LAE) using the forced swimming test (FST), the most widely used animal model of depression. LAE was orally administered to rats three times, i.e., 24, 5, and 1 h prior to the FST. The administration of LAE (3428 mg/kg body weight) showed a significant reduction of the immobility time in the FST, the effect of which was comparable to that of the synthetic antidepressant, imipramine (30 mg/kg). In addition, the same dose of LAE did not change the locomotor activity in the open field test. These results suggest that LAE might have antidepressant-like effects that are independent of motor stimulation. Furthermore, the active ingredients of LAE were suggested to be non-volatile constituents, because linalool, the main aroma constituent of lavender, was completely removed during the preparation of LAE. Possible contribution of rosmarinic acid and that of apigenin glycosides to the antidepressant-like effects of LAE were discussed on the basis of their content in LAE.

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Section: Resultsmentioning

confidence: 72%

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Kageyama

Ueno²,

Oshio

et al. 2012

FSTR

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“…Such a U-shaped activity curve has been reported for some herbal medicines. [16][17][18] Although the reasons have not been clarified, we considered that higher dosage of genistein, such as 100 mg/kg, might exert detrimental effects 19) and thus diminish the antidepressant-like effect.…”

Section: Discussionmentioning

confidence: 99%

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Kageyama

Sakakibara

Zhou

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…var, major recorded in the Chinese Pharmacopoeia, 1) mainly contain hyperoside (HP), a ‰avonol glycoside, whose quality is controlled via determining HP using highperformance liquid chromatographic (HPLC) method. Thereby, many researches about HP appeared in literature, such as, the treatment of antidepressant, 2) cancer therapy, 3) strong inhibitor of HBsAg and HBeAg secretion in 2.2.15 cells and DHBV-DNA levels in the HBV-infected duck model, 4) possessing cytoprotective properties against oxidative stress by scavenging intracellular ROS and enhancing antioxidant enzyme activity, 5) protecting against the oxidative damage induced by TBHP, 6) and remarkable wound healing and anti-in‰ammatory. 7) Otherwise, many methods including capillary zone electrophoresis with electrochemical detection, 8) HPLC 9 11) and LC-MS/MS 12) have been reported for quantiˆcation of HP in various herbal medicines and biological ‰uids.…”

Section: Introductionmentioning

confidence: 99%

LC Determination and Pharmacokinetic Study of Hyperoside in Rat Plasma after Intravenous Administration

et al. 2010

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A simple and speciˆc high-performance liquid chromatographic (HPLC) method was developed for the pharmacokinetic study of hyperoside (HP, isolated from the leaves of Crataegus pinnatiˆda Bge. var. major ) in rats after intravenous administration. The plasma samples were deproteinized with methanol after addition of internal standard (I.S.), baicalin. HPLC analysis was performed on a Diamonsil C18 analytical column, using methanol-0.6％ aqueous phosphoric acid (45：55, v/v) as the mobile phase with UV detection at 340 nm. The calibration curve was linear over the range of 0.8921 59.7125 mg/ml in rat plasma. The average extraction recovery of HP was 99.33±0.86％, and the relative standard deviations (R.S.D.s) of the intra-and inter-day precisions were no more than 7.8 and 2.5％, respectively. The lower limit of quantiˆcation (LLOQ) was 0.8921 mg/ml. The validated method was successfully applied during a pharmacokinetic study in rats after intravenous administration of HP at diŠerent doses, and all the results indicated that the pharmacokinetics of HP in rats obeyed nonlinear processes.

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Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.

Cited by 96 publications

References 10 publications

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

LC Determination and Pharmacokinetic Study of Hyperoside in Rat Plasma after Intravenous Administration

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