Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Abstract

Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.

Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation

“…The results showed that it contained many different active constituents, such as chlorogenic acid and isoorientin. Previous studies reported that flavonoids contributed to the pharmacological activities and showed antidepressant effects, as well as antioxidant effects ( Hritcu et al, 2017 ). Chlorogenic acid is a polyphenol found in plant families, which suggests that the antidepressant-like effects are mediated through decrease immobility time in the tail suspension test and the FST ( Park et al, 2010 ).…”

Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple

“…Many phenylpropanoids and flavonoids are involved in the responses to oxidative stress [14][15][16] , drought stress 17 , and disease resistance [18][19][20][21] . In Vitis vinifera, genes related to phenylpropanoid metabolism have been found to be less induced and/or more repressed in drought-sensitive rootstocks 22 .…”

Intervention in Neuropsychiatric Disorders by Suppressing Inflammatory and Oxidative Stress Signal and Exploration of In Silico Studies for Potential Lead Compounds from Holigarna caustica (Dennst.) Oken leaves

“…Polyphenols are the major constituents of herbal medicine having multifaceted biological actions [86], such as phenolic acids which boost up the brain antioxidant status by scavenging wide range of ROS and metal ions, which also inhibit signaling system of inflammation and its key inflammatory mediators, thus improving anxiety and depression [87]. Besides, flavonoids are the class of compounds which suppress oxidative nitrosative-stress, attenuate neuroinflammation, potentiate GABA A receptor-Cl ion channel complex, increase monoamines, serotonin, and dopamine levels in the CNS, and also modulate monoaminergic neurotransmitter [88]. In our previous research, we revealed that MEHC can effectively suppress in both central and peripheral nociception pathways, which prove that the bioactive compounds of MEHC can act on the central nervous system by crossing the blood brain barrier (BBB).…”