Antidepressant in animal models of depression and study of cognitive property

Mankar, Swapnali Suresh; Turan, Satish Premsingh; Mankar, Swapnil Suresh; Shelke, Pradip Ashruji

doi:10.30574/gscbps.2019.7.3.0069

GSC Biol. and Pharm. Sci.

2019

DOI: 10.30574/gscbps.2019.7.3.0069

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Antidepressant in animal models of depression and study of cognitive property

Swapnali Suresh Mankar¹,

Satish Premsingh Turan²,

Swapnil Suresh Mankar³

et al.

Abstract: Depression characterized by significant depression of mood and impairment of function .In whole study evaluate the antidepressant activity of ethanolic extract of Bacopa monnieri Linn, to assess the pharmacodynamic interaction of drug with standard nootropic antidepressant, determine effect of drug alone and in combination with standard antidepressant in brain on amino acid neurotransmitter and acetylcholine esterase activity. Despair Swim test and tail suspension test study of interaction of ethanolic extract… Show more

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Cited by 2 publications

References 13 publications

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The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Brimson

Prasanth

et al. 2021

Sci Rep

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Bacopamonnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B. monnieri's efficacy as a neuroprotective drug and as a nootropic against various neurological diseases. Literatures were collected, following Prisma guidelines, from databases, including Scopus, PubMed, Google Scholar, and Science Direct and were scrutinized using a quality scoring system. Means, standard deviations and ‘n’ numbers were extracted from the metrics and analyzed. Jamovi computer software for Mac was used to carry out the meta-analysis. The selected studies suggested that the plant extracts were able to show some improvements in healthy subjects which were determined in Auditory Verbal Learning Task, digit span-reverse test, inspection time task and working memory, even though it was not significant, as no two studies found statistically significant changes in the same two tests. B. monnieri was able to express modest improvements in subjects with memory loss, wherein only a few of the neuropsychological tests showed statistical significance. B. monnieri in a cocktail with other plant extracts were able to significantly reduce the effects of Alzheimer’s disease, and depression which cannot be solely credited as the effect of B. monnieri. Although in one study B. monnieri was able to potentiate the beneficial effects of citalopram; on the whole, currently, there are only limited studies to establish the memory-enhancing and neuroprotective effects of B. monnieri. More studies have to be done in the future by comparing the effect with standard drugs, in order to establish these effects clinically in the plant and corroborate the preclinical data.

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The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Brimson

Prasanth

et al. 2021

Sci Rep

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Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder

Singh,

Sarwat,

Gupta

2024

CPD

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Abstract:: Bipolar disorder is a neuropsychiatric disease characterized by an abundance of undesired ideas and thoughts associated with recurrent episodes of mania or hypomania and depression. Alterations in the circuits, including the prefrontal cortex, striatum, and limbic system, regulate mood and cause variation in several crucial neurotransmitters, including serotonin, dopamine, GABA, and glutamate. Imbalances in dopamine levels have been implicated in the manic phase, while variance in serotonin is linked to depressive episodes. The precise pathophysiology of bipolar disorder is still unknown. Though different treatments are available, like lithium, risperidone, valproic acid, etc., which are widely used, they come with certain limitations, including narrow therapeutic index, hypothyroidism, weight gain, extrapyramidal symptoms, etc. The interest in herbal- based treatments for bipolar disorder arises from the desire for alternative, potentially more natural, and holistic approaches with fewer side effects. The current review focuses on the potential effects of herbal drugs and their derivatives to alleviate the symptoms of bipolar disorder.

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Antidepressant in animal models of depression and study of cognitive property

Cited by 2 publications

References 13 publications

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder

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