Antidepressant-like and anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa)

Anxiolytic effects of ketamine in animal models of posttraumatic stress disorder

“…Over the past decades, many studies have suggested that several neurotrophic factors and related signaling cascades might be involved in the pathophysiology of mood disorders, including depression and PTSD (Broekman et al 2007;Pivac et al 2012;Zhang et al 2013). The hippocampus is a limbic structure that is important in the control of learning and memory and in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis.…”

Translocator protein mediates the anxiolytic and antidepressant effects of midazolam

“…TSPO ligands play a significant role in the therapeutic treatment of anxiety and depression. Certain TSPO ligands, such as AC-5216 (Emapunil, XBD173) and YL-IPA08, have been shown to enhance neurosteroidogenesis in the brain and to exert anxiolytic/antidepressant activity in some rodent models (Kita et al, 2004;Zhang et al, 2014a). The anxiolytic/antidepressant effects of TSPO agents are related to their ability to increase neurosteroid biosynthesis, as confirmed by studies involving key enzyme inhibitors of neurosteroid biosynthesis, including finasteride (Kita and Furukawa, 2008).…”

“…The animals were selected based on previous studies evaluating the activity of anxiolytic and antidepressants (Kita et al, 2004;Zhang et al, 2014a). The male species was selected since the stage of estrous cycle of the female animals affected the evaluation of neurosteroids (Kita and Furukawa, 2008).…”

Therapeutic actions of translocator protein (18 kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases

“…However, Owen et al [67] reported high TSPO binding variability of XBD173 across human subjects, and XBD173 did not show superiority over placebo in a phase II trial with patients with generalized anxiety disorder [68]. Other TSPO ligands, such as ZBD-2 and YL-IPA08, have been shown to exert anxiolytic effects in rats and mice [69][70][71]. Furthermore, YL-IPA08 reduced contextual fear in rodent models of post-traumatic stress disorder [69,70] (Table 1).…”

“…Other TSPO ligands, such as ZBD-2 and YL-IPA08, have been shown to exert anxiolytic effects in rats and mice [69][70][71]. Furthermore, YL-IPA08 reduced contextual fear in rodent models of post-traumatic stress disorder [69,70] (Table 1).…”