Antidepressant-like effect of triterpenoids extracts from <i>Poria cocos</i> on the CUMS rats by 16S rRNA gene sequencing and LC–MS metabolomics

Gao, Xiaoxia; Feng, Yan; Xue, Huanhuan; Meng, Meidai; Qin, Xuemei

doi:10.1080/10826076.2020.1737107

Cited by 12 publications

(12 citation statements)

References 54 publications

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“…Within the order of Erysipelotrichales, some studies reported lower neurogenesis and BDNF levels with an increase in family Erysipelotrichaceae [55,81] or genus Allobaculum [68,79,81] and family Turicibacteriaceae or genus Turicibacter [57]. In the study by Ribeiro et al [57] Turicibacteriaceae and Turicibacter positively correlated to neurogenesis after a longer course of the high-fat diet.…”

Section: Taxamentioning

confidence: 94%

“…However, there were several positive correlations at genus level. Gao et al [68] and Guida et al [76] found the diminishment of the genus Lachnobacterium to be unfavorable regarding BDNF levels. These authors further found that the decrease of genus Lachnospira and genus Roseburia led to the same outcome.…”

Section: Taxamentioning

confidence: 99%

“…Major depressive disorder is a key modulator of adult neurogenesis and BDNF levels [10,11]. Three reports [47,59,68] studied the effect of unpredictable chronic mild stress (a model of stress-induced depression) on the gut microbiota and neurogenesis or BDNF. DCX+ cells and Firmicutes abundance were reported to be reduced in one study [59], while the other two studies found reduced BDNF levels parallel to increased Firmicutes abundance [47,68].…”

Section: Taxamentioning

confidence: 99%

“…Three reports [47,59,68] studied the effect of unpredictable chronic mild stress (a model of stress-induced depression) on the gut microbiota and neurogenesis or BDNF. DCX+ cells and Firmicutes abundance were reported to be reduced in one study [59], while the other two studies found reduced BDNF levels parallel to increased Firmicutes abundance [47,68]. Several systematic reviews concluded that there is no consensus in the abundance of Firmicutes phylum in models of depression supporting the irregularities seen in our results [69][70][71].…”

Section: Taxamentioning

confidence: 99%

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Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-derived Neurotrophic Factor

Agnihotri¹,

Mohajeri²

2022

Preprint

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Growing evidence suggests a possible involvement of the intestinal microbiota in generating new neurons, but a detailed breakdown of the microbiota composition is lacking. In this report, we systematically reviewed preclinical rodent reports addressing the connection between the composition of the intestinal microbiota and neurogenesis and neurogenesis-affecting neurotrophins in the hippocampus. Various changes in bacterial composition from low taxonomic resolution at the phylum level to high taxonomic resolution at the species level were identified. As for neurogenesis, studies predominantly used doublecortin (DCX) as a marker of newly formed neurons or bromodeoxyuridine (BrdU) as a marker of proliferation. Brain-derived neurotrophic factor (BDNF) was the only neurotrophin found researched in relation to the intestinal microbiota. Phylum Actinobacteria, genus Bifidobacterium and genus Lactobacillus found the strongest positive while phylum Firmicutes, phylum Bacteroidetes and family Enterobacteriaceae as well as germ-free status, showed the strongest negative correlation towards neurogenesis or BDNF mRNA expression. Age, short-chain fatty acids (SCFA), obesity and chronic stress were recurring topics in all studies identified. Overall, these findings add to the existing evidence of a connection between microbiota and processes in the brain. To better understand this interaction, further investigation based on analyses of higher taxonomic resolution and clinical studies would be a gain to the matter.

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Section: Taxamentioning

confidence: 94%

Section: Taxamentioning

confidence: 99%

Section: Taxamentioning

confidence: 99%

Section: Taxamentioning

confidence: 99%

See 2 more Smart Citations

Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-derived Neurotrophic Factor

Agnihotri¹,

Mohajeri²

2022

Preprint

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“…Similarly, alkali-soluble polysaccharides have exhibited their antidepressant-like effects by regulating neurotransmitters and alleviating neuroinflammation ( Chen et al, 2021 ). Indeed, petroleum ether extract of Wolfiporia cocos has been confirmed to improve depression-like behavior by acting on gut microbiota and metabolites in chronic unpredictable mild stress (CUMS) rats ( Gao et al, 2020 ). However, to date, most of the reported triterpenes of Wolfiporia cocos have been triterpene acids.…”

Section: Introductionmentioning

confidence: 99%

Total Triterpenes of Wolfiporia cocos (Schwein.) Ryvarden & Gilb Exerts Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Rat Model and Regulates the Levels of Neurotransmitters, HPA Axis and NLRP3 Pathway

et al. 2022

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Purpose:Wolfiporia cocos is frequently used in traditional Chinese medicine to treat depression. However, antidepressant-like effects of the main active ingredients of Wolfiporia cocos, total triterpenes of Wolfiporia cocos (TTWC), are not well studied. This study aimed to investigate those effects and explore their specific mechanisms of action in depth.Methods: Chemical components of TTWC were analyzed using LC-MS. Depression-like behavior in rats were induced by chronic unpredictable mild stress (CUMS). The suppressive effects of TTWC (60, 120, 240 mg/kg) against CUMS-induced depression-like behavior were evaluated using the forced swimming test (FST), open field test (OFT) and sucrose preference test (SPT). Levels of 5-hydroxytryptamine (5-HT), glutamate (GLU), corticotropin-releasing hormone (CRH), interleukin-1 beta (IL-1beta), interleukin-18 (IL-18), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in different groups were determined by ELISA. Western blotting (WB) was used to detect the expression of NLRP3, ASC, pro-caspase-1, caspase-1, pro-IL-1beta, IL-1beta, pro-IL-18, and IL-18 in the prefrontal cortex. Additionally, the mRNA levels of NLRP3, ASC, caspase-1, IL-1beta and IL-18 were detected by RT-PCR.Results: A total of 69 lanostane-type triterpene acids of TTWC were identified. The results showed that TTWC exhibited an antidepressant-like effect in CUMS rats, reversed the decreased sugar preference in the SPT, reduction of immobility time in the FST, reduced the rest time, increased the total moving distance in the OFT. TTWC increased 5-HT levels and decreased GLU levels in the hippocampus. Moreover, TTWC decreased CRH levels in serum, indicating the regulation of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, reduced serum levels of IL-1beta, IL-18, IL-6, and TNF-alpha. The WB results implied that TTWC inhibited the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 in the prefrontal cortex and enhanced the expression of pro-caspase-1, pro-IL-1beta, and pro-IL-18. Although most of the results were not significant, PCR results showed that TTWC inhibited the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 in the prefrontal cortex.Conclusion: TTWC treatment exerted an antidepressant-like effect and regulates neurotransmitters, HPA axis and NLRP3 signaling pathway. These results indicated the potential of TTWC in preventing the development of depression.

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Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

Chen

Xiao

Chen

et al. 2021

Food Research International

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Antidepressant-like effect of triterpenoids extracts from Poria cocos on the CUMS rats by 16S rRNA gene sequencing and LC–MS metabolomics

Cited by 12 publications

References 54 publications

Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-derived Neurotrophic Factor

Involvement of Intestinal Microbiota in Adult Neurogenesis and the Expression of Brain-derived Neurotrophic Factor

Total Triterpenes of Wolfiporia cocos (Schwein.) Ryvarden & Gilb Exerts Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Rat Model and Regulates the Levels of Neurotransmitters, HPA Axis and NLRP3 Pathway

Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

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