Antidepressant-like effects and mechanisms of flavonoids and related analogues

Guan, Liping; Liu, Bingyu

doi:10.1016/j.ejmech.2016.05.026

Cited by 112 publications

(77 citation statements)

References 92 publications

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“…Noteworthy, the antidepressant-like activity has been demonstrated for rosmarinic acid (32), luteolin (33), rutin (34,35) and catechin (36). Moreover, previous studies have shown that tannins and flavonoids can possess antide-pressant effects (37,38). In this regard, it is notable that the antidepressant activity of S. elegans has been attributed to a flavon, named isosakuranetin-5-O-rutinoside (39).…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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Objectives: As some species of the Salvia family have been shown to exert antidepressant-like activity, the aim of this study was to investigate the antidepressant effects of the aqueous and hydroalcoholic extracts of Salvia mirzayanii and Salvia macrosiphon, two endemic species of salvia in Iran. Methods: In total, 148 eight-week-old male albino mice (25-35 g) were used to carry out the forced swimming test. The effects of different doses of the aqueous (100-1800 mg/kg) and hydroalcoholic extracts (75-900 mg/kg) of Salvia mirzayanii and Salvia macrosiphon on immobility, climbing, and swimming behaviors were examined. Fluoxetine and imipramine were used as control drugs. The effects of extracts on locomotor activity were also evaluated. Results: High doses of the aqueous extracts of both plants and hydroalcoholic extract of Salvia mirzayanii produced a significant reduction in immobility and increase in swimming compared to the control group. The hydroalcoholic extract of Salvia macrosiphon did not show any significant effect on immobility and swimming. Only some doses of hydroalcoholic extract of Salvia mirzayanii and aqueous extract of Salvia macrosiphon showed a significant increase in climbing behavior. The aqueous and hydroalcoholic extract of both plants caused a decrease in spontaneous activity. Conclusions: The findings of this study indicated that the aqueous and hydroalcoholic extracts of Salvia mirzayanii and the aqueous extract of Salvia macrosiphon had antidepressant-like activity. In addition, the hydroalcoholic extract of Salvia mirzayanii and the aqueous extracts of Salvia macrosiphon were more effective fractions of these plants. These endemic Iranian Salvia species may have potential therapeutic effects for depression.

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Section: Discussionmentioning

confidence: 99%

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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“…Previous studies by Freitas et al in 2014 and Mai et al in 2015 reported that many flavonoids possess antioxidant, antiinflammatory, and antidepressant activities in animal studies [27,28]. The monoamine theory of depression indicates that, the main biochemical causes of depression are metabolic disorders of monoamine neurotransmitters that are involved in NE, 5-HT, and DA signaling [29,30]. Thus, the anxiolytic-antidepressant effects of O. barrelieri, could involve mechanisms both dependent and independent of the neurogenesis process in many brain areas by setting of a new physiological state, which would probably facilitate an increase of monoamines (serotonin) action [31; 32].…”

Section: Discussionmentioning

confidence: 98%

Effects of the Aqueous Extract of Oxalis Barrelieri on Some Murine Models of Acute Depression

2020

ARC Journal of Neuroscience

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According to a report by the World Health Organization (WHO) and the World Bank Group released on June 12th, 2015, 400 million people do not have access to essential health services and 6% people in low-income countries are exposed to the extreme poverty [1]. With three of the Millennium Development Goals calling for improved health, the strategies currently being promoted by WHO are in the direction of security, efficiency, good quality, availability, preservation and good regulation of traditional and complementary medicine in general and more particularly medicinal plants [2]. In many countries worldwide, traditional medicine is an important and often underestimated part of health services. The use of plants to cure or prevent chronic and mental diseases has a long history dating back to antiquity; for example the lantana tree, which is known for its many antimicrobial properties; it is particularly effective against bronchitis and other respiratory infections [3]. Now days, the international community is increasingly recognizing that invisible disabilities, such as mental health, are one of the most neglected but most critical development challenges for achieving the internationally agreed development goals. The most common mental disorders are depression and anxiety. Depression, often called "evil of the century" is not a recent concept, but its origin is as far away as the memory of medical literature [4].

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“…Some studies have reported antidepressant effect of some flavonoids and flavonoids containing plant extracts [54]- [55]. For instance, Hypericum perforatum is a strong antidepressant of plant origin; its antiimmobility effect has been attributed to the presence of rutin and quercetin [54][55][56]. More also, Ginkgo biloba L. (Ginkoaceae) leaf extract has demonstrated antiimmobility effect in despair swim test [57].…”

Section: Discussionmentioning

confidence: 99%

Butanol Fraction of Olax Subscorpioidea Produces Antidepressant Effect: Evidence for the Involvement of Monoaminergic Neurotransmission

et al. 2018

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This study sought to investigate involvement of monoaminergic mechanism in the antidepressant action of butanol fraction (BF) of Olax subscorpioidea in rodents and the bioactive principles present. Butanol fraction was evaluated for antidepressant-like effect in the tail suspension, forced swimming and open field tests. All animals were treated with BF (5, 10 & 20 mg/kg) thirty minutes prior to the tests. On the other hand, monoaminergic neurotransmission involvement was probed by pre-treating animals with yohimbine hydrochloride (1 mg/kg, α antagonist), prazosin (62.5 µg/kg, α antagonist), propranolol (2 mg/kg, non-selective β antagonist), sulpiride (50 mg/kg, D receptor blocker), haloperidol (0.2 mg/kg, non-selective D receptor blocker), metergoline (4 mg/kg, i.p., a 5HT-receptor blocker) and PCPA (100 mg/kg, i.p., inhibitor of tryptophan hydroxylase), fifteen minute before treatment with BF (10 mg/kg). Identification of the major bioactive constituents was done by HPLC. The findings show that BF (5 & 10 mg/kg) significantly decreased immobility in despair tests of depression without effect on locomotor activity. The data also shows that anti-immobility effect of BF (10 mg/kg) in the TST was reversed by prazosin, yohimbine, haloperidol, sulpiride, metagoline and PCPA but not with propranolol. Bioactive principles present are caffeic acid, rutin, morin and quercetin. In conclusion, our findings show that BF produces antidepressant-like effect, which may be dependent on its interaction with the monoaminergic system.

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Antidepressant-like effects and mechanisms of flavonoids and related analogues

Cited by 112 publications

References 92 publications

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Effects of the Aqueous Extract of Oxalis Barrelieri on Some Murine Models of Acute Depression

Butanol Fraction of Olax Subscorpioidea Produces Antidepressant Effect: Evidence for the Involvement of Monoaminergic Neurotransmission

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