Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor

Jiang, Huili; Zhang, Xuhui; Lü, Jun; Meng, Hong; Sun, Yang; Yang, Xiaojian; Zhao, Bingcong; Bao, Ting

doi:10.3389/fpsyt.2018.00102

Cited by 44 publications

(47 citation statements)

References 52 publications

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“…In addition, the social interaction test has revealed behavioral dysfunction [31]. These changes are accompanied by decreased hippocampal expression of BDNF [14]. In line with these previous findings, the present study found lower hippo- Total distance travelled in the OF test was significantly lower in the stress group than in the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies have indicated that BDNF expression in the salivary glands changes in response to stress [28,29]. Moreover, it is well established that the concentration of BDNF in blood decreases following stress in humans and various animal species [14,22]. The present findings indicate that social isolation stress also induces a reduction of BDNF in saliva and blood.…”

Section: Discussionsupporting

confidence: 70%

“…In this study, social isolation stress elicited behavioral changes in rats, as assessed using the OF and EPM tests. Rats exposed to chronic stress are known to show reduced locomotor activity in the OF test [14], and in the present study stressed rats showed a reduction in the total distance walked in both tests. In addition, the increased time spent in the enclosed arms was considered due to this lower locomotor activity.…”

Section: Discussionsupporting

confidence: 66%

“…Animal models of social isolation stress are frequently used for investigating the mechanisms underlying neuropsychiatric disorders [13]. Socially isolated model rats show behavioral deficits in various tests, including the Morris water maze [11], open-field (OF) [14], and elevated plus maze (EPM) [15]. Additionally, changes in blood metabolites have been observed in response to social isolation stress [8].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, tyrosine kinase B (TrkB), which is the BDNF receptor, is also reduced in the hippocampus in schizophrenia [21]. Additionally, model rats with mild chronic stress show a reduction in the concentration of serum BDNF [14], and stressful life events can reduce the serum concentration of BDNF in humans [22]. It is well established that saliva is an extremely useful diagnostic source for several diseases in humans, and could eventually replace blood sampling [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Effect of social isolation stress on saliva BDNF in rat

Nakagawa

Saruta

et al. 2019

J Oral Sci

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Salivary glands produce various compounds, including brain-derived neurotrophic factor (BDNF), which serve as biomarkers of stress-related disorders. Social isolation-induced stress models a form of chronic mild stress that induces neurodegenerative changes in the brain and behavioral alterations. This study employed a rat model to determine whether social isolation stress affects BDNF levels in saliva. Male Sprague-Dawley rats were randomly allocated to social isolation stress (1 animal/cage) or control (3-4 animals/cage) groups and reared for 8 weeks. The concentration of BDNF was quantified in specific brain regions, blood, and saliva using enzyme-linked immunosorbent assay (ELISA). The levels of expression of Bdnf and tyrosine kinase B (TrkB) mRNA were quantified using reverse transcriptase-polymerase chain reaction. Behavioral alterations were analyzed using the open-field and elevated plus maze assays. The BDNF concentration was lower in the hippocampus, prefrontal cortex, blood, and saliva of the stress group than in those of the controls. Trkb expression in the hippocampus and prefrontal cortex was decreased by social isolation stress. Moreover, the social isolation stress group showed behavioral deficits in both tests. In conclusion, these findings indicate that social isolation stress may reduce the expression of BDNF protein in blood and saliva, thus providing a potentially valuable biomarker for diagnosis of stress-related disorders.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of social isolation stress on saliva BDNF in rat

Nakagawa

Saruta

et al. 2019

J Oral Sci

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Paternal Depression and Risk of Depression Among Offspring

et al. 2023

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ImportanceExisting epidemiological evidence is equivocal as to whether paternal depression poses a consequent risk of depression in offspring; meta-analysis of findings can help inform preventative intervention efforts.ObjectiveTo conduct a systematic review and meta-analysis of observational studies examining the association between paternal and offspring depression.Data SourcesEmbase, PubMed, PsycINFO, Scopus, and Web of Science databases were searched between inception and December 2022.Study SelectionThe review included all observational studies that investigated the association between paternal and offspring depression and 10 606 studies were initially identified.Data Extraction and SynthesisThis systematic review and meta-analysis was performed following the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines. The review protocol was prospectively registered in PROSPERO. Summary odds ratios (ORs) and 95% CIs were pooled using inverse variance weighted random effect meta-analysis. Subgroup and sensitivity analyses were performed.Main Outcomes and MeasuresThe main outcome of interest was offspring depression measured using recognized depression assessment tools.ResultsSixteen observational studies published between 2002 and 2021 were included, with a combined sample of 7 153 723 father-child dyads. A meta-analysis of these studies showed that paternal depression was associated with an increased risk of depression in offspring (OR, 1.42; 95% CI, 1.17-1.71). The risk was higher among offspring exposed to paternal depressive disorders (OR, 1.65; 95% CI, 1.28-2.12) than those exposed to depression as defined by a nonclinical symptom scale (OR, 1.12; 95% CI, 1.06-1.19). Sensitivity analysis revealed consistent pooled estimates ranging from 1.35 (95% CI, 1.12-1.62) to 1.45 (95% CI, 1.18-1.78).Conclusions and RelevancePaternal depression was associated with subsequent offspring depression. This finding shows the intergenerational transmission of mental health problems and suggests that mental health interventions benefit not only the patient but also the family as a whole, including both parents.

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Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

Zeng

Tian

et al. 2020

Anim Models and Exp Med

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Background:The chronic unpredictable mild stress (CUMS) model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression. However, there are no widely recognised standards for strategies for modeling and for behavioral testing. The present study aimed to optimize the protocols for food deprivation and the sucrose preference test (SPT) for the CUMS model. Methods:We first evaluated the effects of different long periods of food deprivation on the body weight of Sprague Dawley (SD) rats by testing food deprivation for 24 hours (8:00-8:00 + ), food deprivation for 12 hours during the daytime (8:00-20:00) and food deprivation for 12 hours at night (20:00-8:00 + ). Next, we established a SD rat CUMS model with 15 different stimulations, and used body weight measurement, SPT, forced swim test (FST), open field test (OFT) and Morris water maze (MWM) test to verify the success of the modeling. In the SPT, consumption of sucrose and pure water within 1 and 12 hours was measured.Results: Twelve hours of food deprivation during the daytime (8:00-20:00) had no effect on body weight, while 12 hours of food deprivation at night (20:00-8:00 + ) and 24 hours of food deprivation (8:00-8:00 + ) significantly reduced the mean body weight of the SD rats. When SPT was used to verify the successful establishment of the CUMS rat model, sucrose consumption measured within 12 hours was less variable than that measured within 1 hour. Conclusions:Twelve hours of food deprivation in the daytime (8:00-20:00) may be considered a mild stimulus for the establishment of a CUMS rat model. Measuring sucrose consumption over 12 hours is recommended for SPT. K E Y W O R D S chronic unpredictable mild stress, forced swim test, Morris water maze, open field test, sucrose preference test, weight body

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Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor

Cited by 44 publications

References 52 publications

Effect of social isolation stress on saliva BDNF in rat

Effect of social isolation stress on saliva BDNF in rat

Paternal Depression and Risk of Depression Among Offspring

Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

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