Paternal Depression and Risk of Depression Among Offspring

Dachew, Berihun Assefa; Ayano, Getinet; Duko, Bereket; Lawrence, Blake J.; Betts, Kim; Alati, Rosa

doi:10.1001/jamanetworkopen.2023.29159

Cited by 12 publications

(2 citation statements)

References 53 publications

(183 reference statements)

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“…Paternal depression has also been associated with subsequent offspring depression. 28 Our study confirms the suggestion that the supporting role men assume after TOP is not only a necessary coping strategy of men but very important for women's mental health and for the family as a whole. In | 1211…”

Section: Discussionsupporting

confidence: 87%

Men don't cry: The supporting role as necessary for women's well‐being after termination of pregnancy

Alexopoulos,

Tmej,

Naderer

et al. 2023

Intl J Gynecology & Obste

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ObjectivesThe present study investigated similarities and differences of grief between men and women as part of the parental couple 1 year after termination of pregnancy (TOP) following a diagnosis of fetal anomaly.MethodsWe applied a method triangulation approach. We assessed several aspects of perinatal grief, depressive symptoms, posttraumatic stress, and anxiety as well as health‐related quality of life. In addition, we conducted qualitative interviews with the men to explore the fathers' roles in the partnership during pregnancy, the time of the diagnosis, TOP, and afterwards.ResultsWomen showed a more elevated grief response compared with men. Qualitative data revealed that men in our sample were mainly concerned with their partners' well‐being and concentrated on supporting their partners rather than on their own emotions. In addition, the supportive role of the male partner plays a central role in the well‐being of women and the man's coping with the situation.ConclusionIn clinical work, but also when developing new questionnaires, the specific role of the male partners needs to be considered more thoroughly. Particular attention should be paid to identify the men who find it difficult to assume the supporting role.

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Section: Discussionsupporting

confidence: 87%

Men don't cry: The supporting role as necessary for women's well‐being after termination of pregnancy

Alexopoulos,

Tmej,

Naderer

et al. 2023

Intl J Gynecology & Obste

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“…Epidemiological and ancestral exposure studies also suggest potential presence of epigenetic inheritance in humans (Hart and Tadros, 2019; Senaldi and Smith-Raska, 2020; Vågerö et al ., 2022; Dachew et al ., 2023; Kaufman et al ., 2023; Niu et al ., 2023; Santilli and Boskovic, 2023). Additionally, considering the obvious difficulties in conducting human cross-generational studies (Senaldi and Smith-Raska, 2020; Santilli and Boskovic, 2023), molecular support for paternal germline inheritance of environmental effects in humans has recently been found in terms of father’s smoking showing association with offspring blood DNA methylation (Kitaba et al ., 2023).…”

Section: Introductionmentioning

confidence: 99%

Multi-omics data analysis supporting inheritance of acquired traits in humans

Sharma

2023

Preprint

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Emerging evidence increasingly supports germline mediated non-DNA sequence-based inheritance of environmentally induced traits in animals including mammalian models. Epidemiological and ancestral exposure studies also suggest possible presence of epigenetic inheritance in humans. Notably, cross-species conservation of phenotypic responses in non-genetic inheritance has recently been shown in transcriptomic analysis of Drosophila and rodent models. Here, an unbiased analysis of available human and animal model multi-omics data is presented that supports inheritance of induced traits in humans. First, in an analysis feasibility survey, physical exercise was identified as the lone environmental factor that is known to affect conserved physiological pathways and to induce inheritance in animal models, and at the same time, the effects of which on human cohort sperm DNA methylome, and human cohort, rat, mouse and Drosophila coding and/or non-coding somatic transcriptome have also been multiply described. The hypothesis was thus tested that exercise induced human sperm DNA methylation changes can specifically explain exercise induced human and animal model somatic transcriptome changes. For controlling the analysis, bariatric surgery, identified as the lone environmental factor for which human cohort sperm DNA methylome and somatic transcriptome datasets are multiply available, was used. Remarkably, the hypothesis was supported in all pre-specified tests, involving gene set overlap, gene ontology enrichment, promotor methylation and gene regulation directionalities, and coding and non-coding transcriptome interactions. The results presented support germline encoding of acquired traits in humans, thus suggesting existence of epigenetic inheritance in our species.

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Factors Associated with Fathers’ Mental Health Difficulties in an Australian Help-Seeking Sample

Ritorto,

McMahon,

Wallace

et al. 2024

J Child Fam Stud

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Fathers are at increased risk of mental health difficulties such as depression during the first postnatal year, however little is currently known about the extent to which fathers experience symptoms of anxiety and stress, and the factors associated with these symptoms. This study aimed to: (1) investigate the extent to which fathers accessing support to strengthen their coparenting relationship through a community health organisation experience depressive, anxiety and stress symptoms during the first postnatal year, and (2) examine associations between a broad range of individual, child, and family factors and fathers’ depressive, anxiety, and stress symptoms during the first postnatal year. This study involved secondary analysis of routinely collected data from 170 fathers of children aged 0–12 months who were enroled in a coparenting intervention programme delivered by a community health organisation in Melbourne, Australia. Elevated symptoms of stress were reported by ~28% of fathers, while elevated symptoms of depression and anxiety were reported by ~26% and 16% of fathers, respectively. Multiple regression analyses revealed evidence for associations between reduced parental self-efficacy and higher depressive and stress symptoms, while infant regulation difficulties and increased interparental conflict were associated with higher levels of stress. This study highlights that fathers are at risk of mental health difficulties during the first postnatal year. Findings demonstrate the importance of undertaking a broad assessment of fathers’ mental health during the first postnatal year and provide important insights into individual, child, and family factors that may represent optimal targets for prevention and early intervention.

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Paternal Depression and Risk of Depression Among Offspring

Cited by 12 publications

References 53 publications

Men don't cry: The supporting role as necessary for women's well‐being after termination of pregnancy

Men don't cry: The supporting role as necessary for women's well‐being after termination of pregnancy

Multi-omics data analysis supporting inheritance of acquired traits in humans

Factors Associated with Fathers’ Mental Health Difficulties in an Australian Help-Seeking Sample

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