Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba

Wang, Yulu; Wang, Jingxia; Hu, Xiao-Xu; Chen, Li; Qiu, Zhi-Kun; Zhao, Nan; Yu, Zi-Dan; Sun, Shu-Zheng; Xu, Yuanyuan; Guo, Yan; Liu, Chang; You-zhi, Zhang; Li, Yunfeng; Yu, Chang‐Xi

doi:10.1016/j.jep.2015.12.029

Cited by 87 publications

(44 citation statements)

References 34 publications

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“…The CUS-induced behavioral parameters can be reversed by the chronic administration of antidepressants 7, 24 . Our results showed that similar to Ser (15 mg/kg i.g.…”

Section: Discussionmentioning

confidence: 99%

“…The detection was performed as described previously 7, 28 . Also, the brain tissues were dissected at the end of behavioral tests in 24 h after the last drug treatment on ice by a binocular dissection microscope and homogenized in an ice-cold tissue lysis buffer containing 0.1 g/L of L-cysteine, 0.5 mM Na 2 EDTA and 0.4 M HClO 4 (5.0 μL/mg).…”

Section: Methodsmentioning

confidence: 99%

“…There has been considerable popular interest in using natural extracts and plant preparations to treat depressive-like disorder 7 . Puerarin is a flavonoid glycoside that is extracted from the root of the leguminous plants pueraria lobata and Thomson Kudzuvine Root, and its chemical name is 8-β-D-glucopyranosyl-4′,7-dihydroxyisoflavone 8, 9 .…”

Section: Introductionmentioning

confidence: 99%

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Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Qiu

Zhang

Zhong

et al. 2017

Sci Rep

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The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity. However, acute puerarin treatment did not ameliorate the antidepressant- and anxiolytic- like effects in FST and NSFT, respectively. In addition, enzyme linked immunosorbent assay (ELISA) and high performance liquid chromatography-electrochemical detection (HPLC-ECD) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus of post-CUS rats. Furthermore, puerarin (60 and 120 mg/kg, i.g) blocked the increased corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH). Collectively, repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.

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“…The CUS-induced behavioral parameters can be reversed by the chronic administration of antidepressants 7, 24 . Our results showed that similar to Ser (15 mg/kg i.g.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Qiu

Zhang

Zhong

et al. 2017

Sci Rep

Self Cite

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“…BDNF is essential for hippocampal development, and its expression is relatively sensitive to stress. It has been shown that CUMS can induce a reduction in the hippocampal volume and BDNF levels, which may be signs of cognitive impairment [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…This study will shed lights on the mechanism of the anti-depressant effects of the saponins components from Zhimu-Baihe. 7 …”

Section: Introductionmentioning

confidence: 99%

Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression

Wang²,

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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Simultaneous determination of five compounds of fried Radix Paeoniae Alba extract in beagle dogs plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its application in a pharmacokinetic study

Cheng,

Yuan,

et al. 2023

Biomedical Chromatography

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In this present study, we developed a reliable and simple ultra‐performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) assay for the simultaneous quantification of paeoniflorin, albiflorin, oxypaeoniflorin, benzoylpaeoniflorin and isomaltopaeoniflorin in beagle dog plasma. We also analyzed the pharmacokinetics of those components after oral administration of fried Radix Paeoniae Alba (FRPA) in beagle dogs. Plasma samples were processed by protein precipitation with methanol. Chromatographic separation was performed with a Waters HSS‐T3 C18 column (100 × 2.1 mm, 1.8 μm, kept at 40°C) using multiple reaction monitoring mode. A gradient elution procedure was used with solvent A (0.02% formic acid–water) and solvent B (0.02% formic acid–acetonitrile) as mobile phases. Method validation was performed as US Food and Drug Administration guidelines, and the results met the acceptance criteria. The method we establish in this experiment was successfully applied to the pharmacokinetic study after oral administration of FRPA extract to beagle dogs.

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Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba

Cited by 87 publications

References 34 publications

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression

Simultaneous determination of five compounds of fried Radix Paeoniae Alba extract in beagle dogs plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its application in a pharmacokinetic study

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