Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair

Zhang, Hualin; Li, Zhong; Zhou, Zhongliu; Yang, Hongyan; Zhong, Zhaohui; Cai-xia, Lou

doi:10.1016/j.pbb.2015.10.018

Cited by 55 publications

(53 citation statements)

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“…Zhang et al. studied the antidepressant‐like effect of GRb3 and its four deglycosylated derivatives and found that the effect of GRg3 is more potent than that of GRb3. Liu et al.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

Ma¹,

Guan²,

Ju³

et al. 2019

J of Separation Science

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Notoginsenoside Fc, a protopanaxadiol-type saponin, shows multi-pharmacological activities. Chemical stability evaluation plays a crucial role in drug development.In this study, the forced degradation behavior of Notoginsenoside Fc was investigated under hydrolytic and oxidative conditions. A specific ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed for the separation, identification, and characterization of the degradation products of Notoginsenoside Fc. Fifty potential degradation products were formed via deglycosylation, dehydration, hydration, isomerization, side-chain cleaving, oxidation, and superoxidation. Notoginsenoside Fc was subjected to different pH solutions, temperatures, and time periods to assess its stability. A sensitive ultra high performance liquid chromatography-tandem mass spectrometry was developed for the quantification of Notoginsenoside Fc, notoginsenoside ST-4, notoginsenoside Ft1, and relative quantification of notoginsenoside Ft2, 20(R)-notoginsenoside Ft2, notoginsenoside SFt3, and notoginsenoside SFt4. The assay was linear over the concentration range (R 2 > 0.997) with the lowest limit of quantification of 0.02 μg/mL for Notoginsenoside Fc, Notoginsenoside ST-4, and Notoginsenoside Ft1. The intra-day precision, inter-day precision, and accuracy of the three analytes were within accepted levels. The degradation kinetics of Notoginsenoside Fc in pH 1 and 3 solutions fits to first-and second-order kinetics, respectively. The degradation of Notoginsenoside Fc is pH-, temperature-, and time-dependent.

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“…Zhang et al. studied the antidepressant‐like effect of GRb3 and its four deglycosylated derivatives and found that the effect of GRg3 is more potent than that of GRb3. Liu et al.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

Ma¹,

Guan²,

Ju³

et al. 2019

J of Separation Science

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“…Subsequent studies revealed that many components of P. notoginseng saponins act as the major bioactive players of the anti‐depression effects of P. notoginseng extracts such as ginsenosides Rb3, Rb1 and Rg1, partially mediated by brain‐derived neurotrophic factor (BDNF) pathway (Cui, Jiang, & Xiang, ; Jiang et al, ). Moreover, our previous investigations showed that deglycosylated derivative of ginsenoside Rb3 (Rg3) performed its depression‐inhibiting roles by modulating signaling pathways associated with BDNF and cAMP response element binding protein (CREB) using cellular and animal models (Zhang et al, ; Zhang, Zhou, Chen, Zhong, & Zhong, ). In consideration of the complex constitution of P. notoginseng extracts and the complicated pathological processes linked with depression, the molecular mechanism mediating anti‐depression effects of total saponins from the leaves of P. notoginseng (SLPN) remains far from being fully understood.…”

Section: Introductionmentioning

confidence: 99%

Total saponins from the leaves of Panax notoginseng inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression

et al. 2018

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ObjectivesTotal saponins from the leaves of Panax notoginseng saponins (SLPN) could inhibit development of depression, but the underlying mechanisms remains unclear. This study aimed to address the roles of circular RNAs in depression inhibition by SLPN.MethodsThe mouse chronic unpredictable mild stress (CUMS) model was established, which were confirmed by mouse weight, forced swimming test (FST) and tail suspension test (TST). Effects of SLPN on depression were evaluated in CUMS through these same assays. Circular RNA profiles in mouse ventral medial prefrontal cortex (VMPC) and hippocampus of CUMS mice were determined by high‐through sequencing, followed by confirmation via qRT‐PCR. Overexpression of mmu_circ_0001223 was done by transfection of PC12 cell through lentiviral system. Protein abundances of cAMP response element binding protein 1(CREB1) and brain‐derived neurotrophic factor (BDNF) were evaluated by western blotting.ResultsMouse body weight, immobility time in FST and immobility time in TST of CUMS mice were significantly recovered by SLPN treatment. A large number of circular RNAs were differentially expressed in the ventral medial prefrontal cortex (VMPC) and hippocampus tissues of CUMS mice. Among them, mmu_circ_0001223 expression was greatly decreased in CUMS mice, but significantly elevated by SLPN treatment. The protein levels of CREB1 and BDNF were also remarkably promoted in CUMS mice by treatment of SLPN. Overexpression of mmu_circ_0001223 enhanced CREB1 and BDNF protein levels in PC12 cells.ConclusionSLPN regulate the expression of large number circular RNAs in CUMS mice, which might be important mediators of SLPN's anti‐depression effects.

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“…Panax notoginsen (Burk) F.H. Chen (Araliaceae) (PN) is a commonly used Chinese medicine, the root of which (Sanqi in Chinese) has been used for the treatment of hemoptysis, hemostatic, and hematoma in China and other Asian countries for its hemostatic and cardiovascular effects for more than several hundreds of years [26][27][28]. To the best of our knowledge, over 200 chemical constituents have been isolated from Panax notoginseng, but the main ingredients are Panax notoginseng saponins ( PNS ) [29] ， being classified into four types: protopanaxadiol, protopanaxatriol, ocotilloltype, and oleanolic acid constituents.…”

Section: Introductionmentioning

confidence: 99%

“…And there are others reported to be flavonoids, cyclopeptides, saccharides and inorganic elements [30]. Pharmacological studies have shown that notoginseng and its extracts have many functions, such as anti-inflammatory [16,20,31,32], anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose [27,33,34], blood pressure [35][36][37], inhibition of neuronal apoptosis [14,38,39] and neuronal protection [30].…”

Section: Introductionmentioning

confidence: 99%

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

Xie¹,

Meng²,

Zhai³

et al. 2018

Preprint

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Panax notoginseng, as traditional Chinese medicine, has a long history of high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose and blood pressure, inhibition of neuronal apoptosis and neuronal protection, and its main ingredients are Panax notoginseng saponins (PNS). Currently, Panax notoginseng may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation. However, the underlying effects and the mechanisms of Panax notoginseng and its containing chemical constituents (PNS) on these depression-related or anxiety-related diseases has not been completely established. This review summarized the antidepressant or anxiolytic effects and mechanisms of PNS, and analyzed network targets of antidepressant or anxiolytic actions with network pharmacology tools to provide directions and references for further pharmacological studies and new ideas for clinical treatment of nervous system diseases and drug studies and development.

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Antidepressant-like effects of ginsenosides: A comparison of ginsenoside Rb3 and its four deglycosylated derivatives, Rg3, Rh2, compound K, and 20(S)-protopanaxadiol in mice models of despair

Cited by 55 publications

References 54 publications

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

Identification and characterization of forced degradation products and stability‐indicating assay for notoginsenosidefc by using UHPLC‐Q‐TOF‐MS and UHPLC‐MS/MS: Insights into stability profile and degradation pathways

Total saponins from the leaves of Panax notoginseng inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

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