Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS)

Chandrasekhar, Y.; Ramya, E. M.; Navya, K.; Kumar, G. Phani; Anilakumar, K.R.

doi:10.1016/j.biopha.2016.12.031

Cited by 43 publications

(29 citation statements)

References 51 publications

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“…Tannins are watersoluble compounds of the polyphenolic group. Tannins have exerted antidepressant action in previous studies (38,40), and might be responsible for antidepressant effects of the aqueous extract of S. macrosiphon. There is no other previous report regarding the phytochemicals present in the aqueous extract of S. macrosiphon to be justified for its antidepressant activity.…”

Section: Discussionmentioning

confidence: 96%

“…Noteworthy, the antidepressant-like activity has been demonstrated for rosmarinic acid (32), luteolin (33), rutin (34,35) and catechin (36). Moreover, previous studies have shown that tannins and flavonoids can possess antide-pressant effects (37,38). In this regard, it is notable that the antidepressant activity of S. elegans has been attributed to a flavon, named isosakuranetin-5-O-rutinoside (39).…”

Section: Discussionmentioning

confidence: 99%

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Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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Objectives: As some species of the Salvia family have been shown to exert antidepressant-like activity, the aim of this study was to investigate the antidepressant effects of the aqueous and hydroalcoholic extracts of Salvia mirzayanii and Salvia macrosiphon, two endemic species of salvia in Iran. Methods: In total, 148 eight-week-old male albino mice (25-35 g) were used to carry out the forced swimming test. The effects of different doses of the aqueous (100-1800 mg/kg) and hydroalcoholic extracts (75-900 mg/kg) of Salvia mirzayanii and Salvia macrosiphon on immobility, climbing, and swimming behaviors were examined. Fluoxetine and imipramine were used as control drugs. The effects of extracts on locomotor activity were also evaluated. Results: High doses of the aqueous extracts of both plants and hydroalcoholic extract of Salvia mirzayanii produced a significant reduction in immobility and increase in swimming compared to the control group. The hydroalcoholic extract of Salvia macrosiphon did not show any significant effect on immobility and swimming. Only some doses of hydroalcoholic extract of Salvia mirzayanii and aqueous extract of Salvia macrosiphon showed a significant increase in climbing behavior. The aqueous and hydroalcoholic extract of both plants caused a decrease in spontaneous activity. Conclusions: The findings of this study indicated that the aqueous and hydroalcoholic extracts of Salvia mirzayanii and the aqueous extract of Salvia macrosiphon had antidepressant-like activity. In addition, the hydroalcoholic extract of Salvia mirzayanii and the aqueous extracts of Salvia macrosiphon were more effective fractions of these plants. These endemic Iranian Salvia species may have potential therapeutic effects for depression.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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“…However, the exact mechanism underlying depression remains largely unknown. The majority of current antidepressants are based on monoamine neurochemical alterations, including tricyclic antidepressants, and selective serotonin and noradrenalin reuptake inhibitors (3). Numerous patients suffering from MDD are resistant to currently available antidepressants, experiencing a long delay in activity and adverse effects (4).…”

Section: Introductionmentioning

confidence: 99%

Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats

et al. 2018

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Major depression is a multifactorial disease. Emerging evidence has suggested that autophagy is involved in the pathological process of depressive disorders. Bafilomycin A1 (Baf A1), is an inhibitor of vacuolar H+‑ATPase that is frequently used at high concentrations to block late‑phase autophagy. However, whether Baf A1 has antidepressant effects remains to be elucidated. The current study aimed to evaluate the antidepressant effects of Baf A1 in rats with chronic unpredictable mild stress (CUMS) and its potential mechanism. The CUMS animal model was established. The sucrose preference test, open‑field test (OFT) and forced swim test (FST) were applied to evaluate the depressive behavior. Synaptic plasticity‑associated proteins synaptophysin and postsynaptic density protein 95 were measured by western blotting and immunofluorescence. Apoptosis‑ and autophagy‑associated proteins in addition to pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α, were detected by western blotting, reverse transcription‑quantitative polymerase chain reaction or ELISA. A 4‑week treatment period with Baf A1 markedly ameliorated CUMS‑induced behavioral abnormalities, including increasing sucrose intake, improving locomotor activity in the OFT, and decreasing immobility time in the FST. In addition, treatment with Baf A1 restored the dysregulation of synaptic plasticity and inhibited neuroinflammation in rats exposed to CUMS. Furthermore, Baf A1 decreased the levels of apoptosis‑ and autophagy‑associated proteins induced by CUMS. The present study demonstrated that Bafilomycin A1 resulted in antidepressant effects in rats, which may be mediated by the reversal of apoptosis, autophagy and neuroinflammation in the hippocampus.

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“…Reduced sucrose consumption in stressed animals is another essential indicator of anhedonia. Anhedonia is an important symptom of depression [30]. In this investigation, repeated administration of AE and WE ameliorated CUMS-induced decrease in sucrose consumption.…”

Section: Discussionmentioning

confidence: 58%

Antidepressant-like activities of extracts of the fungus Paecilomyces tenuipes M98

Han

et al. 2019

Psychiatry and Clinical Psychopharmacology

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Objective: Depression is an disease that seriously endangers the physical and mental health of human body. However, in view of the limitation of existing antidepressants, it's urgent to find new antidepressants from natural products. The aim of this study was to evaluate the effect of Paecilomyces tenuipes, which is an important entomogenous fungus in China. Methods: This research was intent to investigate the antidepressant actions of P. tenuipes M98 extracts using a battery of behavioural models including tail suspension test (TST) and forced swimming test (FST), 5-HTP-induced head twitch response and chronic unpredictable mild stress (CUMS) in mice. Results: Fifteen days treatment with aqueous and ethanol extracts signifificantly decreased the duration of immobility in TST and FST, without signifificant changes in locomotor activity. Moreover, chronic application of extracts for 21 days signifificantly improved the depressivelike behaviours of CUMS mice, including reduced body weight and sucrose preference and lengthened immobility time in TST and FST. In addition, extracts produced a signifificant increase in 5-hydroxytryptamine and dopamine, but not noradrenaline, levels in hypothalamus. These fifindings suggested that this action of P. tenuipes might be related to the regulation of serotonergic and dopaminergic systems, which were further confirmed via 5-HTP induced head-twitch test. In addition, P. tenuipes M98 extracts also displayed antioxidative effffects. Conclusion: P. tenuipes M98 extracts present excellent antidepressant-like activities, which might be explained by regulation of neurotransmitters and alleviation of oxidative stress.

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Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS)

Cited by 43 publications

References 51 publications

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats

Antidepressant-like activities of extracts of the fungus Paecilomyces tenuipes M98

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