Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model

Lin, Yan; Chen, Yi‐Chun; Lu, Kuan-Hung; Huang, Yun-Ju; Panyod, Suraphan; Liu, Wei-Ting; Yang, Shuhui; Lu, Yun-Sheng; Chen, Mei-Hsing; Sheen, Lee‐Yan

doi:10.1016/j.jep.2021.114194

Cited by 11 publications

(5 citation statements)

References 53 publications

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“…The species used in all of the animal models were limited to rats and mice: we did not find instances of other rodent species that have been utilized as antidepressant screens ( Kramer et al, 1998 ; Alo et al, 2019 ). Fourteen of the studies used rats ( Matsuzaki et al, 2013 ; Minami et al, 2013 ; Tan et al, 2016 ; Liu C. et al, 2017 ; Song et al, 2017 ; Wang et al, 2017 ; Huang et al, 2020 ; Nascimento et al, 2020 ; Lin et al, 2021a ; Zhang L. et al, 2021 ; Lin et al, 2021b ; Anuar et al, 2022 ; Cheng, 2023 ; Rakoczy et al, 2023 ), while the remaining 36 studies used mice to test for antidepressant-like effects ( Zhou et al, 2005 ; Nishizawa et al, 2007 ; Koo et al, 2008 ; Singh et al, 2014 ; Tianzhu et al, 2014 ; Socala et al, 2015 ; Yao et al, 2015 ; Gupta et al, 2016 ; Huang et al, 2016 ; Nakamichi et al, 2016 ; Song et al, 2016 ; Xu, 2016 ; Bao et al, 2017 ; Liu Y. et al, 2017 ; Lin et al, 2017 ; Chiu et al, 2018 ; Mahmoudi et al, 2018 ; Ryu et al, 2018 ; Jin et al, 2019 ; Li et al, 2019 ; Song et al, 2020 ; Li H. et al, 2021 ; Li TJ. et al, 2021 ; Zhang T. et al, 2021 ; Chong et al, 2021 ; Hossen et al, 2021 ; Park et al, 2021 ; Singh et al, 2021 ; Zhao et al, 2021 ; Chou et al, 2022 ; Mi et al, 2022 ; Xin et al, 2022 ; Yu et al, 2022 ; Ezurike et al, 2023 ; Zhao et al, 2023 ; Hernandez-Leon et al, 2024 ).…”

Section: Resultsmentioning

confidence: 99%

“…A variety of animal models of depression and antidepressant screens were used to examine mushroom and fungus antidepressant efficacy. By far the most common animal model used to induce a depressive-like phenotype in rodents was the unpredictable chronic mild stress paradigm (UCMS), with 14 studies implementing this model ( Zhou et al, 2005 ; Tianzhu et al, 2014 ; Tan et al, 2016 ; Liu C. et al, 2017 ; Song et al, 2017 ; Wang et al, 2017 ; Li et al, 2019 ; Huang et al, 2020 ; Lin et al, 2021a ; Zhang L. et al, 2021 ; Lin et al, 2021b ; Zhao et al, 2021 ; Xin et al, 2022 ; Cheng, 2023 ); rats were used in the majority (9) of these studies. The second most frequent model involved the use of chronic restraint stress, in four mouse studies ( Nakamichi et al, 2016 ; Chiu et al, 2018 ; Chong et al, 2021 ; Zhao et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

“…Antidepressant-like effects on the SPT and/or FST were observed with Cordyceps militaris (34-day, 125–500 mg/kg, p.o.) ( Lin et al, 2021b ) and (42-day, 20–40 mg/kg, i.g.) ( Tianzhu et al, 2014 ), Paecilomyces tenuipes (28-day, 40–1,000 mg/kg, p.o.)…”

Section: Resultsmentioning

confidence: 99%

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A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Wang,

Kim,

Aleksandrova

et al. 2024

Front. Pharmacol.

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One of the most important developments in psychopharmacology in the past decade has been the emergence of novel treatments for mood disorders, such as psilocybin for treatment-resistant depression. Psilocybin is most commonly found in different species of mushroom; however, the literature on mushroom and fungus extracts with potential antidepressant activity extends well beyond just psilocybin-containing mushrooms, and includes both psychedelic and non-psychedelic species. In the current review, we systematically review the preclinical literature on mushroom and fungus extracts, and their effects of animal models of depression and tests of antidepressant activity. The PICO structure, PRISMA checklist and the Cochrane Handbook for systematic reviews of intervention were used to guide the search strategy. A scoping search was conducted in electronic databases PubMed, CINAHL, Embase and Web of Science. The literature search identified 50 relevant and suitable published studies. These included 19 different species of mushrooms, as well as seven different species of other fungi. Nearly all studies reported antidepressant-like effects of treatment with extracts. Treatments were most commonly delivered orally, in both acute and chronically administered studies to predominantly male rodents. Multiple animal models of depression were used, the most common being unpredictable chronic mild stress, while the tail suspension test and forced swim test were most frequently used as standalone antidepressant screens. Details on each experiment with mushroom and fungus species are discussed in detail, while an evaluation is provided of the strengths and weaknesses of these studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Wang,

Kim,

Aleksandrova

et al. 2024

Front. Pharmacol.

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show abstract

“…Currently prescribed antidepressants like fluoxetine decrease IL-1β while reversing behaviors in chronic stress models. However, combining fluoxetine treatment with a compound isolated from plants, Lilium [92], cordyceps militaris [93], or an enriched environment [37] may have a synergistic effect. Other compounds isolated from plants have similar effects, including eucommia ulmoides Oliv [49]; saikosaponin-d (SSd), a triterpene saponin [47]; isofraxidin [39]; and β-glucan, a unique agent that has immunomodulatory activity without eliciting a proinflammatory response [94,95].…”

Section: Il-1βmentioning

confidence: 99%

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

White,

Elias,

Orozco

et al. 2024

IJMS

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The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and being overwhelmed for an extended duration. This can result in a persistent proinflammatory response in the peripheral and central nervous system (CNS), resulting in cellular, physiological, and behavioral effects. Compounding stressors may increase the risk of chronic-stress-induced inflammation, which can yield serious health consequences, including mental health disorders. This review summarizes the current knowledge surrounding the neuroinflammatory response in rodent models of chronic stress—a relationship that is continually being defined. Many studies investigating the effects of chronic stress on neuroinflammation in rodent models have identified significant changes in inflammatory modulators, including nuclear factor-κB (NF-κB) and toll-like receptors (TLRs), and cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6. This suggests that these are key inflammatory factors in the chronic stress response, which may contribute to the establishment of anxiety and depression-like symptoms. The behavioral and neurological effects of modulating inflammatory factors through gene knockdown (KD) and knockout (KO), and conventional and alternative medicine approaches, are discussed.

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“…Cordycepin (Kato et al, 2021), found in the aqueous and ethanolic extracts of O. sinensis (Yong et al, 2016;Lin et al, 2021), and O. sinensis polysaccharides (Yang et al, 2021) have been demonstrated to exert the main therapeutic effects of O. sinensis. It is a nucleoside analog (3'-deoxyadenosine), which is considered as the most important bioactive constituent of O. sinensis with significant therapeutic potential (Paterson, 2008;Tuli et al, 2013).…”

Section: Components Of the Aqueous And Ethanolic Extracts Of Ophiocor...mentioning

confidence: 99%

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges

Chen

et al. 2022

J. Zhejiang Univ. Sci. B

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Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery, radiotherapy, chemotherapy, immunotherapy, and endocrine therapy are currently the main treatments for this cancer type. However, some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy, resulting in limited treatment efficacy. Consequently, traditional Chinese medicinal materials (TCMMs) as natural products have become an attractive source of novel drugs. In this review, we summarized the current knowledge on the active components of animal-derived TCMMs, including Ophiocordyceps sinensis-derived cordycepin, the aqueous and ethanolic extracts of O. sinensis, norcantharidin (NCTD), Chansu, bee venom, deer antlers, Ostrea gigas, and scorpion venom, with reference to marked anti-breast cancer effects due to regulating cell cycle arrest, proliferation, apoptosis, metastasis, and drug resistance. In future studies, the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies. Furthermore, large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.

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Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model

Cited by 11 publications

References 53 publications

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges

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