Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors

Geng, Chang‐An; Yang, Tonghua; Huang, Xiaoyan; Ma, Yun‐Bao; Zhang, Xuemei; Chen, Ji‐Jun

doi:10.1016/j.jep.2018.12.013

Cited by 38 publications

(21 citation statements)

References 28 publications

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“…cons. [1][2][3]. Pharmacological studies show that Uncaria rhynchophylla has an antagonistic effect on Ca 2+ , which can block external Ca 2+ influx and release of internal Ca 2+ [4].…”

Section: Introductionmentioning

confidence: 99%

Tissue Distribution of Hirsutine and Hirsuteine in Mice by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Zhou

Chen

2020

Journal of Analytical Methods in Chemistry

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Hirsutine and hirsuteine were two alkaloid monomers extracted from the traditional Chinese medicine Uncaria rhynchophylla, which have pharmacological effects such as antihypertension, anti-infection, and heart protection. An ultrahigh-performance liquid chromatography-mass spectrometry was established for the determination of hirsutine and hirsuteine in tissues (liver, kidney, heart, spleen, brain, and lung), and their absorption, distribution, and metabolism were studied for providing information on its pharmacological mechanism. UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) was used for chromatographic separation. The mobile phase was acetonitrile-0.1% formic acid, with a gradient elution, and the total run time was 4 min. Electrospray was used in the positive ion mode, and the multiple reaction monitoring (MRM) mode was for quantification. The acetonitrile precipitation method was used to remove protein-treated mouse plasma and tissue homogenate samples. In the concentration range of 2–5000 ng/g, hirsutine and hirsuteine in tissues showed good linearity (r > 0.995), and the lower limit of quantification was 2 ng/g. In the plasma and liver tissues, the interday and intraday precision of hirsutine and hirsuteine was less than 15%, the accuracy was between 90.9% and 110.1%, and the average recovery was better than 73.0%. The matrix effect was between 86.2% and 104.7%. The results showed that the precision, accuracy, recovery, and matrix effects meet the requirements for the study on the distribution of hirsutine and hirsuteine. After intraperitoneal administration of 10 mg/kg hirsutine and hirsuteine in mice, the distribution levels were highest in liver and kidney tissues, followed by the spleen and lung. Hirsutine and hirsuteine were low in brain tissue, but had obvious distribution, suggesting that they may pass through the blood-brain barrier.

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“…cons. [1][2][3]. Pharmacological studies show that Uncaria rhynchophylla has an antagonistic effect on Ca 2+ , which can block external Ca 2+ influx and release of internal Ca 2+ [4].…”

Section: Introductionmentioning

confidence: 99%

Tissue Distribution of Hirsutine and Hirsuteine in Mice by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Zhou

Chen

2020

Journal of Analytical Methods in Chemistry

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“…### p < 0.001 vs. normal group, Ã p < 0.05, ÃÃ p < 0.01 vs. control group; n ¼ 6 in each group. (Park et al 2014;Chung et al 2017;Geng et al 2019); and Linderae Radix (烏藥 ) derived from Lindera strychnifolia Fernandez-Villar (Lauraceae) is reported to promote blood circulation (Lee et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of the methanol fraction of modified Seonghyangjeongki-san water extract on transient ischaemic brain injury in mice

Kang

Cho

Lim

et al. 2021

Pharmaceutical Biology

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Context: Recently in Korean medicine, the antioxidant and anti-inflammatory activities of Seonghyangjeongki-san (SHJKS) were reported. However, studies on the specific mechanisms of action of SHJKS for the treatment of ischaemic stroke are still lacking.Objective: This study investigates the mechanism of action of the water extract methanol fraction of modified SHJKS (SHJKSmex) on cerebral ischaemic injury. Materials and methods: C57BL/6 male mice were orally administered SHJKSmex (30, 100, or 300 mg/kg) for 3 consecutive days (2 days, 1 day, and 1 h, respectively) before middle cerebral artery occlusion (MCAO). Twenty-four hours after MCAO, the infarct volumes were measured, brain edoema indices were calculated, and neurological deficit scores were determined. Inflammation-related substances in the ipsilateral hemisphere were determined by western blotting, dichlorofluorescin diacetate, thiobarbituric acidreactive substances assay, and enzyme-linked immunosorbent assay. Results: SHJKSmex pre-treatment at 300 mg/kg decreased infarct volume by 87% and mean brain water content by 90% of the MCAO control group. Moreover, SHJKSmex effectively suppressed the expression of inducible nitric oxide synthase, reactive oxygen species, interleukin 1, and caspases-8 and À9 and increased the B-cell lymphoma 2/Bcl-2-associated X protein ratio (Bcl-2/Bax) in ischaemic mouse brain. The hippocampal pyramidal cell densities were significantly increased in the 300 mg/kg SHJKSmex-administered group compared to the MCAO control group. Discussion and conclusions: SHJKSmex protected the brain from ischaemic stroke in mice through its antioxidant, anti-inflammatory, and antiapoptotic activities. Our findings suggest that SHJKSmex is a promising therapeutic candidate for the development of a new formulation for ischaemia-induced brain damage.

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“…Depresi adalah salah satu penyakit gangguan mental yang ditandai dengan perasaan yang tertekan secara terusmenerus hal ini dapat mempengaruhi suasana hati, perilaku ataupun kesehatan fisiknya (Zhao et al, 2014). Depresi ini dapat menimbulkan penurunan produktivitas kerja, ketergantungan psikotropika atau narkotika, gangguan dalam hubungan sosial (Puspitasari, 2017), bahkan dampak yang paling buruk dapat menyebabkan bunuh diri (Geng et al, 2019). Ketika dilihat dari sisi biologis depresi menyebabkan adanya beberapa gangguan pada neurotransmitter norefinefrin, serotonin dan dopamin (Istriningsih et al, 2018).…”

Section: Pendahuluanunclassified

Review Artikel : Aktivitas Antidepresan Dari Tanaman Famili Rubiaceae

Kartikasari

2021

JIFF

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mental yang ditandai dengan perasaan tertekan secara terus-menerus yang dapat mempengaruhi suasana hati, perilaku maupun kesehatan fisiknya. Depresi dapat berdampak pada menurunnya produktivitas kerja, ketergantungan narkotika dan psikotropika, gangguan dalam hubungan sosisal bahkan sampai menyebabkan bunuh diri. Obatobat depresi yang biasa digunakan adalah obat-obat sintetik dimana obat-obat antidepresan ini menimbulkan beberapa efek samping diantaranya hipotensi, kejang, mulut kering, mual muntah, serta penglihatan kabur sehingga untuk menghindari kondisi tersebut maka digunakan pengobatan alternatif dari tanaman famili Rubiaceae yang berpotensi sebagai antidepresan.Penelitian ini bertujuan untuk mengetahui tanaman-tanaman yang berpotensi sebagai antidepresan dari famili Rubiaceae.Metode yang digunakan yaitu dengan melakukan studi pustaka terkait dengan tanaman famili Rubiaceae yang memiliki aktivitas antidepresan yang terdapat pada jurnal yang bertaraf nasional maupun internasional yang diterbitkan dalam 10 tahun terakhir.Dari hasil penelitian terdapat 7 tanaman famili Rubiaceae yang memiliki potensi sebagai antidepresan diantaranya tanaman Morinda citrifolia Linn, Coffea sp, Uncaria rhynchophylla, Uncaria lanosa Wallich var. appendiculata Ridsd, Mitragyna speciosa Korth, hamelia patents, dan Nuclea latifolia Smith. Tanaman yang memiliki aktivitas antidepresan yang paling besar yaitu tanaman Coffea sp, Uncaria rhynchophylla dan Mitragyna speciosa Korth dengan dosis 10 mg/kg. Dengan disusunya review artikel ini diharapkan dapat memberikan informasi terkait tumbuhan yang memiliki aktivitas antidepresan dari tanaman famili Rubiaceae yang bisa digunakan sebagai alternatif pengobatan depresi Kata kunci: Antidepresan, Rubiaceae.

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Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors

Cited by 38 publications

References 28 publications

Tissue Distribution of Hirsutine and Hirsuteine in Mice by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Tissue Distribution of Hirsutine and Hirsuteine in Mice by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Effects of the methanol fraction of modified Seonghyangjeongki-san water extract on transient ischaemic brain injury in mice

Review Artikel : Aktivitas Antidepresan Dari Tanaman Famili Rubiaceae

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