Antidepressants for polycystic ovary syndrome

Zhuang, Jing; Wang, Xianding; Xu, Liangzhi; Wu, Taixiang; Kang, Deying

doi:10.1002/14651858.cd008575.pub2

Cited by 15 publications

(19 citation statements)

References 40 publications

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“…Patients with PCOS could be medically undertreated or could have milder depression symptoms without need for medical treatment (113). A recent Cochrane review found lack of data on the use of antidepressants in patients with PCOS and studies on their effectiveness in PCOS were requested (114).…”

Section: Depression and Psychiatric Illnessmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Section: Depression and Psychiatric Illnessmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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“…Records screened (1111) Records excluded after title and abstract screening (849) Full-text articles excluded for failing to meet eligibility criteria (74) 22: Not a meta-analysis or a pooled analysis 4: Did not evaluate antidepressants 27: Did not evaluate the efficacy of antidepressants 9 evaluated co-therapy of antidepressant and another drug vs. antidepressants only 7: Did not evaluate an indication of depression or did not report outcomes separately for depression 4: Non-English 1: Duplicate Eligible articles (185) Full-text articles assessed for eligibility (259) Unable to retrieve meta-analyses (3) Records identified through MEDLINE search: Other…”

Section: Figure 1 -Flow Chart Of Eligible Meta-analysesmentioning

confidence: 99%

Meta-analyses with industry involvement are massively published and report no caveats for antidepressants

Ebrahim

Bance

Athale

et al. 2016

Journal of Clinical Epidemiology

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“…The country of origin of the authors included China (n = 11), [29][30][31][32][33][34][35][36][37][38][39] Australia (n = 6), [40][41][42][43][44][45] United Kingdom (n = 5), 43,[45][46][47][48] the United States of America (n = 4), [49][50][51][52] India (n = 3), 44,52,53 Canada (n = 3), 50,54,55 Brazil (n = 2), 41,56 Iran (n = 2), 40,54 Columbia (n = 1), 46 Greece (n = 1), 57 Italy (n = 1), 57 Spain (n = 1), 58 Scotland (n = 1), 59 Luton (n = 1), 48 Netherlands (n = 1) 41 and Saudi Arabia (n = 1). 46 Thirteen reviews explicitly included randomized control trials (RCTs) only [29][30][31][32]34,36,38,42,43,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…46 Thirteen reviews explicitly included randomized control trials (RCTs) only [29][30][31][32]34,36,38,42,43,46,53,57,59 ; 5 reviews included RCTs and phase-1 data of cross-over trials 39,41,44,45,52 ; 2 reviews included RCTs and prospective trials 50,56 ; 2 reviews included RCTs and observational studies 49,58 ; 1 review included RCTs, comparative studies and case series with >5 patients 55 ; 2 reviews included all clinical trials 40,54 ; 3 reviews included all study types 35,48,51 ; and 3 reviews did not state an inclusion criteria for the study type. 33,37,47 Fifteen reviews did not set a language restriction in their literature search 30,31,[39][40][41][43][44][45][46]49,50,52,[56][57][58] ; 11 reviews restricted their search to English publications only…”

Section: Study Characteristicsmentioning

confidence: 99%