Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

Mar, Adam C.; Spreekmeester, Emma; Rochford, Joseph

doi:10.1007/s002130000400

Cited by 71 publications

(50 citation statements)

References 43 publications

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“…injection of this drug on the depression-like symptoms induced by OBX in Wistar rats, to compare the efficacy of these two methods of nicotine administration. We further compared the effect of nicotine to the anti-depressant like effects of TMS, because it is well known that the OBX-rodent model responds well to other anti-depressant therapies [15,21], and we wanted to test the effect of TMS, which has emerged as an alternative to electroconvulsive therapy for the treatment of human depression [13]. Moreover, repetitive TMS reduces immobility time in the FST, which further supports an antidepressant effect for this therapy [22].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

Vieyra-Reyes¹,

Mineur²,

Picciotto³

et al. 2008

Brain Research Bulletin

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In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore, we compared the antidepressant-like effects of nicotine on Wistar rats to those of transcranial magnetic stimulation (TMS), which has emerged as a therapeutic alternative for depression management.Our results show that Wistar rats develop depression-like symptoms, demonstrated by the forced swim test (FST), four weeks after OBX. However, we cannot observe these symptoms in bulbectomized Long Evans rats. Our results suggest that there are some innate differences in susceptibility to stress between these two rat strains.In Wistar rats, voluntary oral nicotine intake (1.2 mg/kg/day for 14 days) as well as nicotine administered as a single daily i.p. injection (1.5 mg/kg/day for 14 days) decrease the depression-like symptoms of OBX. Daily transcranial magnetic stimulation (TMS; 60 Hz and 0.7 mT for two hours per day for 14 days) also decreases depression-like symptoms but is less effective than nicotine.In conclusion, our results support the idea that there are possible innate differences for depression susceptibility and that nicotine and TMS may be useful in the treatment of this syndrome.

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Section: Discussionmentioning

confidence: 99%

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

Vieyra-Reyes¹,

Mineur²,

Picciotto³

et al. 2008

Brain Research Bulletin

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“…A repeated measures analysis of variance was performed using "genotype" as a between subject factor and "time" as a within subjects factor. Path length for each animal was fitted with a random effects exponential model y ϭ c ϩ m⅐e Ϫk⅐x , where y ϭ path length, m ϭ ordinate intercept, k ϭ rate of decline of locomotor activity, x ϭ time, and c ϭ asymptotic final path length traveled in each minute interval (30). Group differences in the parameters of the equation were tested by t test (two-tailed, p Ͻ 0.05).…”

Section: Methodsmentioning

confidence: 99%

A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior

Chen

Holschneider

et al. 2004

Journal of Biological Chemistry

133

126

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A spontaneous monoamine oxidase A (MAO A) mutation (A863T) in exon 8 introduced a premature stop codon, which produced MAO A/B double knock-out (KO) mice in a MAO B KO mouse colony. This mutation caused a nonsense-mediated mRNA decay and resulted in the absence of MAO A transcript, protein, and catalytic activity and abrogates a DraI restriction site. The MAO A/B KO mice showed reduced body weight compared with wild type mice. Brain levels of serotonin, norepinephrine, dopamine, and phenylethylamine increased, and serotonin metabolite 5-hydroxyindoleacetic acid levels decreased, to a much greater degree than in either MAO A or B single KO mice. Observed chase/ escape and anxiety-like behavior in the MAO A/B KO mice, different from MAO A or B single KO mice, suggest that varying monoamine levels result in both a unique biochemical and behavioral phenotype. These mice will be useful models for studying the molecular basis of disorders associated with abnormal monoamine neurotransmitters. (21), indicating that the increase in 5-HT, a preferred substrate for MAO A, and concomitant decrease in 5-HIAA may form the basis for increased aggression, consistent with the association of low 5-HIAA levels in the cerebrospinal fluid of men who exhibit aggressive behavior (22,23). Although increased aggressive behavior has not been observed in MAO B KO mice (21), low platelet MAO B activity in humans is associated with, and considered a marker for, criminal or impulsive behavior (24), although whether this is accompanied in human subjects by a concomitant decrease in MAO A activity or other related genetic or biochemical aberration is not known.MAO A/B KO mice cannot be generated through the breeding of MAO A KO and MAO B KO mice, due to the close proximity of the isoenzyme genes on the X chromosomes, where the two genes are next to each other at their 3Ј tails, organized in opposite orientations with their last exons being less than 24 kb apart (determined by blat analysis of human and mouse MAO A and B

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“…The open-field chamber consisted of a square wooden box (85 Â 85 Â 70 cm 3 ). As conditions of very high brightness are crucial to observe the hyperactivity in OBX-rats (Mar et al, 2000;Song and Leonard, 2005), the inner faces of the walls were covered with aluminium foil and illumination was provided by a 75 W bulb positioned 90 cm directly over the center of the open field (1700-2000 lux). Each rat was placed into the center of the open field and exploratory activity was monitored by a video camera fixed above the arena and relayed to a computer system.…”

Section: Obx and Assessment Of Hyperlocomotionmentioning

confidence: 99%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

130

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Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT 7 ) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT 7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT 7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT 7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action.

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Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

Abstract: These findings suggest that antidepressants restore normal responding by permitting more effective adaptation to novel stimuli.

Cited by 71 publications

References 43 publications

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

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