Antidermatophyte activity of ethanolic extracts of Daniellia oliveri (Fabaceae) and Parinari curatellifolia (Chrysobalanaceae) in Chad

Issakou, BAKARNGA-VIA; Payang, YANKA Pihouli; Christophe, DJEKOTA; Alio, Hamit Mahamat; Otchom, Brahim Boy; Valéry, MBAIGOLMEM Béral; Tidjani, None ABDELSALAM

doi:10.30574/gscarr.2022.13.2.0299

Cited by 3 publications

(1 citation statement)

References 8 publications

(11 reference statements)

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“…The result of this study is also consistent with the report of (Sylvanus et al, 2014), but differ only in absence of flavonoids in ethanolic stem bark of Parinari curatellifolia which our result indicated its presence. Issakou et al (2022) had also reported the presence of tannins, saponins, alkaloids, flavonoids, terpenoids and steroids which is consistent with the findings in this study. This result is also consistent with that of (Omoniwa et al, 2021), who reported the same secondary metabolites including phenolics, tannins, saponins, glycosides, alkaloids, terpenoids, flavonoids, and steroids in the ethanol extract of Parinari curatellifolia stem bark.…”

Section: Discussionsupporting

confidence: 92%

Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice

Michael,

Joshua,

Amah

et al. 2023

Preprint

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Background The use of Parinari curatellifolia for the management of malaria by Africans without scientific validation, prompted this study, to investigate the antimalarial effect of ethanol extract of Parinari curatellifolia stem bark (EEPCSB) in Plasmodium berghei (NK-65)-infected mice. Method Thirty mice (16–21 g) were grouped into six of five mice each. Group 1 (uninfected) served as normal control while groups 2–6 were infected. Group 2 (positive control) was untreated while group 3 (standard control) received 20/120 mg/kg b.w. of arthemeter/lumefantrine, groups 4–6 received 200, 400 and 600 mg/kg b.w. of EEPCSB respectively. The treatment lasted for four consecutive days. Parasitemia, heamatological and biochemical tests were carried out using established methods. The obtained data were analysed using one-way analysis of variance (ANOVA). Result The extract significantly (p < 0.05) suppressed the parasitemia, and produced significant (p < 0.05) increase in the PCV, RBC, and Hgb and a significant (p < 0.05) decrease in the WBC of groups 4–6 compared to the positive control. The liver function marker enzymes - AST, ALT, ALP, and total bilirubin were all significantly (p < 0.05) reduced in the treated animals, while there was a significant (p < 0.05) decrease in the total cholesterol, triacylglycerol and LDL, and a significant (p < 0.05) increase in the HDL of the infected animals compared to the positive control. While there was a significant (p < 0.05) reduction in lipid peroxidation marker MDA in the treated groups, the activities of the SOD and catalase, significantly (p < 0.05) increased compared to the positive control. The GSH concentration reduced significantly (p < 0.05) in the treated groups compared to the untreated group. Conclusion The extract showed excellent antimalarial effect by reducing parasitemia and reversing haematological and biochemical aberrations in Plasmodium berghei-infected mice as demonstrated in this study. Therefore, Parinari curatellifolia stem bark could be a source of lead compound for a novel and effective antimalarial drug.

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Section: Discussionsupporting

confidence: 92%

Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice

Michael,

Joshua,

Amah

et al. 2023

Preprint

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The Potential of Underutilized Plant Resources and Agricultural Wastes for Enhancing Biodiesel Stability: The Role of Phenolic-Rich Natural Antioxidants

Kahimbi,

Kichonge,

Kivevele

2023

International Journal of Energy Research

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Growing concerns about energy security and environmental sustainability have fueled demand for sustainable and renewable energy sources in recent years. Biodiesel, a renewable alternative to conventional fuels, has gained significant attention as a potential source of energy. However, the stability of biodiesel during storage and its susceptibility to oxidation remain major challenges. To address these issues, researchers have turned their focus to the utilization of natural antioxidants. Studies on sources of natural antioxidants, particularly those made from waste, such as food, have been extensively conducted. However, there are still some restrictions, such as inconsistency in quality, the development of microbes, and difficulties with regulations, all of which have an impact on sustainability and the phenolic contents. Phenolic compounds are known for their excellent antioxidant properties and ability to inhibit the oxidation process. The review provides an overview of various underutilized plant resources and agricultural wastes that are rich in phenolic contents and demonstrate higher antioxidant activities, such as Vitex doniana, Uapaca kirkiana, Parinari curatellifolia, Tamarindus indica L, fruit peels, and crop residues. It discusses the extraction methods employed to obtain phenolic antioxidants from these sources and highlights their antioxidant activities. Additionally, the review examines the effects of phenolic antioxidants on key parameters, including induction period, peroxide value, acid value, and viscosity. The review concluded by highlighting the potential of underutilized plant resources and agricultural wastes as sustainable sources of phenolic-rich natural antioxidants for enhancing biodiesel stability. According to the literatures, phenolic antioxidants present in underutilized plant resources and agricultural wastes can chelate metal ions, scavenge free radicals, and break oxidation chain reactions, thereby preventing the degradation of biodiesel. Moreover, the limitation of the use of natural antioxidants in the stabilization of biodiesel like instability at high temperatures has been highlighted.

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Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice.

Michael,

Joshua,

Amah

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The use of Parinari curatellifolia for the management of malaria by Africans without scientific validation, prompted this study, to investigate the antimalarial effect of ethanol extract of Parinari curatellifolia stem bark (EEPCSB) in Plasmodium berghei (NK-65)-infected mice. Method: Thirty mice (16 -21 g) were grouped into six of five mice each. Group 1 (uninfected) served as normal control while groups 2-6 were infected. Group 2 (positive control) was untreated while group 3 (standard control) received 20/120 mg/kg b.w. of arthemeter/lumefantrine, groups 4-6 received 200, 400 and 600 mg/kg b.w. of EEPCSB respectively. The treatment lasted for four consecutive days. Parasitemia, heamatological and biochemical tests were carried out using established methods. The obtained data were analysed using one-way analysis of variance (ANOVA). Result: The extract significantly (p < 0.05) suppressed the parasitemia, and produced significant (p < 0.05) increase in the PCV, RBC, and Hgb and a significant (p < 0.05) decrease in the WBC of groups 4-6 compared to the positive control. The liver function marker enzymes - AST, ALT, ALP, and total bilirubin were all significantly (p < 0.05) reduced in the treated animals, while there was a significant (p < 0.05) decrease in the total cholesterol, triacylglycerol and LDL, and a significant (p < 0.05) increase in the HDL of the infected animals compared to the positive control. While there was a significant (p < 0.05) reduction in lipid peroxidation marker MDA in the treated groups, the activities of the SOD and catalase, significantly (p < 0.05) increased compared to the positive control. The GSH concentration reduced significantly (p < 0.05) in the treated groups compared to the untreated group. Conclusion: The extract showed excellent antimalarial effect by reducing parasitemia and reversing haematological and biochemical aberrations in Plasmodium berghei-infected mice as demonstrated in this study. Therefore, Parinari curatellifolia stem bark could be a source of lead compound for a novel and effective antimalarial drug.

show abstract

Antidermatophyte activity of ethanolic extracts of Daniellia oliveri (Fabaceae) and Parinari curatellifolia (Chrysobalanaceae) in Chad

Cited by 3 publications

References 8 publications

Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice

Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice

The Potential of Underutilized Plant Resources and Agricultural Wastes for Enhancing Biodiesel Stability: The Role of Phenolic-Rich Natural Antioxidants

Antimalarial effect of ethanol extract of Parinari curatellifolia stem-bark in Plasmodium berghei-NK 65 infected mice.

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