Antidiabetic Activity of Aqueous Extract of Cinnamomum cassia in Alloxan- Induced Diabetic Rats

Kamble, Shobha; Rambhimaiah, S.

doi:10.13005/bpj/388

Cited by 19 publications

(11 citation statements)

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“…Kamble et al 16 evaluated the glucose lowering effect of C cassia extract and has reported similar observations consistent to our present study. Kamble et al 16 compared the aqueous extract of C. cassia with glibenclamide and Metformin in diabetic rats. Kamble et al 16 concluded that the extract of C. cassia was as effective as glibenclamide and Metformin.…”

Section: Discussionsupporting

confidence: 92%

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Diabetic Albino Rats

Kazi¹,

Shaikh²,

Azmi³

2016

TPMJ

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Objectives: The present study evaluated the blood glucose, superoxidedismutase (SOD) and glutathione peroxidase (GPX) in Cinnamon cassia bark extract (CCBE)treated alloxan-induced diabetic albino rats. Study Design: Experimental study. Setting: Animalhouse of Al-Tibri Medical College, Karachi was selected for conducting the present study.Period: January 2014 to December 2014. Methodology: A sample of twenty rats was randomlydivided into 4 groups. Rats were grouped as A1 (n=5) – Negative control, A2 (n=5)- Positivecontrols (alloxan treated rats), and experimental groups B1 (n=5) and B2 (n=5) includeddiabetic rats which received 0.3 grams and 0.6 grams of CCBE respectively. Intraperitonealalloxan (120 mg /kg in 0.5 ml dissolved in acetate buffer) was used for induction of diabetes.C. cassia bark extract was prepared under standard protocol. Blood glucose (glucose oxidasemethod), SOD and GPX (Elisa kit) were detected from blood samples after 30 days. Data wasanalyzed on SPSS. Data was analyzed by one- way ANOVA and post-Hoc was used for groupcomparisons. Data was analyzed at 95% CI (p< 0.05). Result: Blood glucose, SOD and GPXshowed statistically significant differences (p<0.036). CCBE treated rats showed low glucoselevels and elevated SOD and GPX enzyme activity (p<0.05).

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Section: Discussionsupporting

confidence: 92%

“…Kamble et al 16 compared the aqueous extract of C. cassia with glibenclamide and Metformin in diabetic rats. Kamble et al 16 concluded that the extract of C. cassia was as effective as glibenclamide and Metformin.…”

Section: Discussionmentioning

confidence: 99%

Diabetic Albino Rats

Kazi¹,

Shaikh²,

Azmi³

2016

TPMJ

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“…Those results taken together suggest that both pancreatic and extrapancreatic mechanism might be involved in its antidiabetic/antihyperglycemic action. However, the extrapancreatic actions could consist of (i) a stimulation of peripheral glucose utilization; (ii) an enhancement of glycolytic and glycogenic processes and/or (iii) a glycemia reduction through the inhibition of glucose intake 21 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

IJPSR

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This study investigated the antidiabetic activity of the aqueous extract of the leaves of Ageratum conyzoides. Streptozotocin induced hyperglycemia male adult albino rats were used to study the antidiabetic effect of Ageratum conyzoides aqueous extract (at doses of 100, 200 and 300 mg/kg respectively). The diabetic rats were housed in metabolic cages, for the whole period of the experiment. Body weight was evaluated at the beginning of the experiment and on days 7, 14, and 21 afterward. Water intake, food intake and urine excretion volume were also estimated. At the end of the experiment the rats were sacrificed and serum insulin concentration, total serum proteins and hepatic glycogen content were estimated. Lipid profile (total cholesterol (TC), High density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides (TG)) were also assessed. The results showed significant effect of stimulating body weight growth at the doses of 200, 300 mg/kg. The effect of the extract on the food, water intake and water excretion showed a significant decrease in the 200 and 300 mg/kg extract treated groups. In treated rats, both doses (200 and 300 mg/kg) induced a significant reduction in serum glucose and the Area Under the glucose Curve, with concomitant increases in serum insulin and protein levels. Furthermore, A. conyzoides treatment improve lipid profile by increase HDL and reducing triglycerides and LDL at 200 mg/kg. The present study clearly indicates that Ageratum conyzoidesaqueous extract leaves exhibited significant antidiabetic activity and supports its uses in traditional medicine.

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“…At the end of the experimental period reduction in the blood glucose level in treated groups denotes the increase in insulin production that helped in enhancing the uptake of glucose in the serum. Kamble and Rambhimaiah (2013) have reported that the presence of flavonoids in the extract may account for the observed hypoglycemic effect since it increases the glucose metabolism, stimulates the insulin secretion, and increases the sensitivity towards insulin. In accordance with the above statement the combined effect of phytochemicals in pomelo had contributed in lowering the blood glucose more efficiently than other treatments.…”

Section: Blood Glucose Levelmentioning

confidence: 99%

Efficacy of Citrus maxima fruit segment supplemented paranthas in STZ induced diabetic rats

Karthiga

Sukhdeo

Lakshminarayan

et al. 2021

Journal of Food Science

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The study was conducted to investigate the efficacy of Citrus maxima (Pomelo) fruit segments fortified paranthas compared to pomelo juice and naringin in streptozotocin‐induced diabetic rats. The animals were divided into nine groups, Groups 1 to 3: negative control; Group 4: diabetic control; Groups 5 through 8: treatments with pomelo juice, naringin, plain paranthas, and pomelo supplemented paranthas; and Group 9 was positive control metformin. The groups were monitored for weight, oral glucose tolerance, insulin tolerance, bioavailability, biochemical parameters, and histopathological studies. Based on the result the group treated with paranthas fortified with pomelo fruit segment (Group 8) showed 19% of overall weight gain, approximately 50% reduction in plasma glucose level and improved serum protein (5.70 g/dl) and serum insulin (8.54 ng/ml) level as compared against diabetic control. The treatments had effectively lowered the level of liver enzyme and lipids (except HDL) in the serum along with the improved renal function. The group treated with pomelo juice and pomelo supplemented paranthas exhibited marked tolerance to the glucose and insulin similar to the positive control. Therefore, the antidiabetic activity was found to be more pronounced in the order of pomelo juice > fortified paranthas > naringin. Since pomelo juice is bitter and astringent in nature, the fruit can be better utilized in the form of fortified paranthas, which exerts antidiabetic effect similar to the positive control metformin. Hence, paranthas supplemented with pomelo fruit segments (bioactives‐rich) aids in the reducing the risk of diabetes and can be recommended to gain nutritional benefits for normal and diabetic populations.

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Antidiabetic Activity of Aqueous Extract of Cinnamomum cassia in Alloxan- Induced Diabetic Rats

Cited by 19 publications

References 0 publications

Diabetic Albino Rats

Diabetic Albino Rats

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Efficacy of Citrus maxima fruit segment supplemented paranthas in STZ induced diabetic rats

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