OBJECTIVE:To investigate the anti-oxidative and anti-nephrotoxic effects of resveratrol in cisplatin induced nephrotoxic albino Wistar rats. METHODS:This quasi-experimental study was performed at Isra University, Hyderabad, Pakistan. Thirty male albino Wistar rats were divided into three g r o u p s : g r o u p -A ( c o n t r o l ) , g r o u p -B ( c i s p l a t i n ) a n d g r o u p -C (cisplatin+resveratrol). Biochemical [serum urea, creatinine and glutathione peroxidase (GPX)] and renal histomorphology was performed in all groups after 21 days of treatment. RESULTS:Difference in mean pre-and post-experimental body weight was observed in all three groups. Mean body weight decreased from 241.7±8.5 gm to 196.50±9.34 gm and from 237±7.4 gm to 207.2±6.56 gm in group-B and group-C respectively. In group-A; mean serum urea was 22.7±2.66 mg/dl, serum creatinine was 0.45±0.05 mg/dl and serum GPX was 1.44±0.13 ηg/ml. In group-B; mean serum urea level was 51±3.65 mg/dl, mean serum creatinine was 0.78±0.05 mg/dl and serum GPX was 0.85±0.11 ηg/ml. In group-C, mean serum urea level was 32.8±1.45 mg/dl, serum creatinine level was 0.41±0.09 mg/dl and serum GPX was 1.53±0.08 ηg/ml. In group-A, renal structure was intact, marked changes were observed in renal histology of group-B while group-C displayed less glomerular damage. The mean distance between visceral and parietal layers of Bowman's capsule was 69.34±0.87 µm in group-A, 216.5±1.32 µm in group-B while 102.22±1.65 µm in group-C. Areas of peritubular fibrosis and congestion were observed in groups B and C but less prominent in group-C compared with group-B. CONCLUSION:Resveratrol therapy is a potent anti-nephrotoxic regime showing promising results in chemotherapy induced nephrotoxicity and oxidative stress.

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Objective: To evaluate the anti diabetic effect of cinnamon extract in alloxaninduced diabetic animal model (albino rats) in comparison with oral hypoglycemic drugs. StudyDesign: An Experimental study. Place of Study: Al Tibri Medical College, Isra University, KarachiCampus. Duration of Study: December 2012 to December 2013. Materials and Methods: Total60 Albino rats of both genders were divided into 6 groups consisting of 10 rats in each group.Each group of animals was further divided into two sub groups containing 5 rats in each groupResults: The results obtained from the data indicated that there is significant reduction in bloodglucose level rats treated with low dose of cinnamon extract. The animals of low dose cinnamonextract (200mg/kg. bw) when compared with other groups; there is a reduction in the bloodglucose level in alloxan induced diabetic rats. Also tolbutamide and acarbose treated groupsshowed better antidiabetic effects as compared with cinnamon extract treated groups (pvalue<0.007 and p value<0.012 respectively), but cinnamon extract treated group showedsynergetic effects when it was given in combination with tolbutamide or acarbose havingsignificant p value<0.001 and p value<0.011 respectively. Conclusions: Tolbutamide andAcarbose showed better anti diabetic effect in comparison with cinnamon extract treated groupswhen used individually. This effect was enhanced when cinnamon was used in combination witheither tolbutamide or acarbose.

The present study evaluated the blood glucose, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in Cinnamon cassia bark extract (CCBE) treated alloxan-induced diabetic albino rats. Study Design: Experimental study. Setting: Animal house of Al-Tibri Medical College, Karachi was selected for conducting the present study. Period: January 2014 to December 2014. Methodology: A sample of twenty rats was randomly divided into 4 groups. Rats were grouped as A1 (n=5)-Negative control, A2 (n=5)-Positive controls (alloxan treated rats), and experimental groups B1 (n=5) and B2 (n=5) included diabetic rats which received 0.3 grams and 0.6 grams of CCBE respectively. Intraperitoneal alloxan (120 mg /kg in 0.5 ml dissolved in acetate buffer) was used for induction of diabetes. C. cassia bark extract was prepared under standard protocol. Blood glucose (glucose oxidase method), SOD and GPX (Elisa kit) were detected from blood samples after 30 days. Data was analyzed on SPSS. Data was analyzed by one-way ANOVA and post-Hoc was used for group comparisons. Data was analyzed at 95% CI (p< 0.05). Result: Blood glucose, SOD and GPX showed statistically significant differences (p<0.036). CCBE treated rats showed low glucose levels and elevated SOD and GPX enzyme activity (p<0.05).