Diabetic Albino Rats; Blood Glucose, Superoxide Dismutase and Glutathione Peroxidase in Cinnamon Cassia Treated

Abstract

The present study evaluated the blood glucose, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in Cinnamon cassia bark extract (CCBE) treated alloxan-induced diabetic albino rats. Study Design: Experimental study. Setting: Animal house of Al-Tibri Medical College, Karachi was selected for conducting the present study. Period: January 2014 to December 2014. Methodology: A sample of twenty rats was randomly divided into 4 groups. Rats were grouped as A1 (n=5)-Negative control, A2 (n=5)-Positive controls (alloxan treated rats), and experimental groups B1 (n=5) and B2 (n=5) included diabetic rats which received 0.3 grams and 0.6 grams of CCBE respectively. Intraperitoneal alloxan (120 mg /kg in 0.5 ml dissolved in acetate buffer) was used for induction of diabetes. C. cassia bark extract was prepared under standard protocol. Blood glucose (glucose oxidase method), SOD and GPX (Elisa kit) were detected from blood samples after 30 days. Data was analyzed on SPSS. Data was analyzed by one-way ANOVA and post-Hoc was used for group comparisons. Data was analyzed at 95% CI (p< 0.05). Result: Blood glucose, SOD and GPX showed statistically significant differences (p<0.036). CCBE treated rats showed low glucose levels and elevated SOD and GPX enzyme activity (p<0.05).

Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders

“…Administration of cinnamon powder at a dose of 75 mg/kg for 30 days significantly increased serum levels of SOD, CAT, GPx, and decreased MDA levels in all diabetic groups receiving cinnamon [98]. These findings were consistent with two other studies, which showed that cinnamon extract administration increased SOD and GPx enzyme activity, with the most significant effect observed at a dose of 200 mg/kg [99,100].…”