Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats

Arunachalam, Karuppusamy; Thangaraj, Parimelazhagan

doi:10.1016/j.jep.2013.03.004

Cited by 66 publications

(31 citation statements)

References 29 publications

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“…[7] Diabetes mellitus is a complex metabolic disease of the endocrine system, characterized by hyperglycemia due to deficiency in insulin secretion, insulin action, or both. [11] This metabolic disease leads to multiple macro-and microvascular difficulties which affect some organs, including the kidneys, heart, skin, and brain. [12] The incidence of the disease is on rise worldwide, is likely to hit 300 million by 2025 with India anticipated to have the biggest number of diabetic cases.…”

Section: Original Articlementioning

confidence: 99%

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Rashid

2017

IJGP

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Introduction: Diospyros melanoxylon Roxb. is traditionally used medicinal plant. Previously, we confirmed the better antiproliferative and antidiabetic activity of ethyl acetate fractions (EAF) obtained from D. Melanoxylon. To assessment the hypothesis if nanoparticle-encapsulated fraction could progress bioactivity. Materials and Methods: We prepared nanoparticle encapsulation based on poly (lactide-co-glycolide) (PLGA) and confirmed encapsulation by scanning electron microscopy. Sub EAF (SEAF) and nanoparticles of sub ethyl acetate (NSEAF) were characterized for their antiproliferative and antidiabetic activity. Antiproliferative activity was performed using the methylene blue assay. Antidiabetic activity was performed on the basis of α-amylase and α-glucosidase assay. Results and Discussion: Comparatively, NSEAF showed better activity on different cancerous cell lines HCT116 (inhibitory concentration 50% [IC 50 ] 32.89 ± 1.71 µg/ml), MCF-7 (IC 50 36.13 ± 0.96 µg/ml) and PC-3 (IC 50 32.39 ± 1.91 µg/ml), and antidiabetic activity on the basis of α-amylase (IC 50 35.62 ± 2.56 µg/ml), and α-glucosidase (IC 50 73.52 ± 1.13 µg/ml) action at a dose-dependent manner. It is also demonstrated that NSEAF exerted very low toxic effect against normal cell lines. Conclusion: For this reason, NSEAF studied in the present research may be considered as possible future drug candidates for the treatment and management of cancer and diabetes.

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Section: Original Articlementioning

confidence: 99%

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Rashid

2017

IJGP

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“…STZ -induced diabetes is known to cause weight loss in animals as a result of proteinuria and insulin deficiency 29 . Insulin deficiency triggers the liver to break down protein into amino acids leading to muscle wasting and excessive weight loss 30,31 which was observed in diabetic control rats. Treated animals started gaining weights after day 7 of the experiment.…”

Section: Pathological Studiesmentioning

confidence: 99%

“…A reduction in the number of WBCs, could also be as a result of diabetes-induced stress 31,47 which breaks down the rats' defensive mechanism. Diabetic rats treated with the extract at 200 mg/kg/day showed improvement in WBC count, which could probably be due to the fact that the extract contains some constituents that stimulate and/or promote the production of WBCs 30 and hence offer some form of protection to the rats' immune system.…”

Section: Pathological Studiesmentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern especially in Sub -Saharan Africa. Indigenous medicinal plants are used for the treatment of diabetes mellitus in most developing countries, like Ghana, but remain to be validated. In the present study, the effect of Myrianthus arboreus ethanol stem bark extract (MAB) (100 -400 mg/kg) on glucose levels in streptozotocin (STZ) (45 mg/kg) induced diabetic rats was investigated using glibenclamide 5 mg/kg/day as the positive control. The effects of the extract on body weight, total protein, serum urea, serum creatinine, bilirubin, lipid profile, haematological indices and serum markers for liver function in normal, treated and untreated diabetic rats were also investigated. Induction of the diabetes in Sprague Dawley rats (150-200 g) resulted in increased levels of serum glucose, total cholesterol, triglycerides and LDL-cholesterol but decreased body weight, serum HDL-cholesterol and haemoglobin levels. Administration of the extract at the three dose levels resulted in significant (P<0.001) reduction in the levels of plasma glucose, cholesterol, LDL-cholesterol, triglycerides and serum urea and serum creatinine. Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also significantly (P<0.001) decreased. The significant decrease in body weight, total protein and HDL-cholesterol which were observed in STZ-induced diabetic rats were normalized after 28 days treatment with the extract. At 200 mg/kg/day, MAB recorded significant (P<0.01) reduction in plasma glucose levels compared to glibenclamide (5 m/kg/day). Thus MAB shows significant hypoglycaemic and antihyperlipidaemic activities in STZ-induced diabetic rats justifying its use in traditional medicine. INTRODUCTION:Diabetes is a metabolic disorder characterized by chronic hyperglycaemia and alterations in carbohydrate, protein and lipid metabolism with absolute or relative deficiencies in insulin secretion and/or insulin production 1 .

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“…It also controlled the increased lipid peroxidation which may be due to the antioxidant effect of flavonoids present in it. Apart from lipids, its treatment normalized the total protein content in diabetic rats, indicating its possible potential of treating kidney disorders [45]. Cassia occidentalis L. (Fabaceae), just like several other Cassia species, also has a similar effect of lowering serum lipids, and serum proteins [46].…”

Section: Plants With Hypoglycemic or Anti-hyperglycemic Activitymentioning

confidence: 99%

Therapeutic Potential of Plant Phenolics for the Management of Diabetic Retinopathy

Pandita¹,

Vaidya²

2014

TOPHARMCJ

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Diabetes is a systemic disease affecting a large proportion of the population worldwide. Hyperglycemia, the major factor responsible for its development, is known to cause both microvascular and macrovascular complications if not controlled in time. Retinopathy is one such microvascular complication of the eye and has been studied extensively. There are biochemical pathways that lead to its progression and are common to other complications, viz. the formation of advanced glycation end products, the activation of protein kinase C, increase in oxidative stress and the polyol pathway. Though there are standard treatments available to manage diabetic retinopathy, there remains a need to explore herbal medicine as an alternative for its treatment. Many herbal preparations alleviating hyperglycemia that are used to treat diabetes or have insulin sensitizing effects are available in the market. These may help managing diabetic retinopathy, too. Many plants are known to produce inhibitors of advanced glycation end products, the aldose reductase (polyol) pathway, and protein kinase C (PKC). Hence, there is a necessity to evaluate the potential of these plants, focussing on individual phytoconstituents like phenolic compounds.

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Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats

Cited by 66 publications

References 29 publications

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Therapeutic Potential of Plant Phenolics for the Management of Diabetic Retinopathy

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