Antidiabetic Activity ofArtemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats

Abstract

Artemisia species have been extensively used for the management of diabetes in folklore medicine. The current study was designed to investigate the antidiabetic and antihyperlipidemic effects of Artemisia amygdalina. Petroleum ether, ethyl acetate, methanol, and hydroethanolic extracts of Artemisia amygdalina were tested for their antidiabetic potentials in diabetic rats. The effect of extracts was observed by checking the biochemical, physiological, and histopathological parameters in diabetic rats. The hydroethanolic and methanolic extracts each at doses of 250 and 500 mg/kg b. w significantly reduced glucose levels in diabetic rats. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), were found to be reduced by the hydroethanolic and methanolic extracts. The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. The histopathological results of treated groups showed the regenerative/protective effect on β-cells of pancreas in diabetic rats. The current study revealed the antidiabetic potential of Artemisia amygdalina being effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.

Liver Dysfunction and Oxidative Stress in Streptozotocin-Induced Diabetic Rats: Protective Role ofArtemisiaTuranica

“…Based on our results, treatment of the STZ-induced diabetic rats separately with A. turanica extract and metformin significantly decreased blood glucose level as compared to the untreated diabetic rats. In the same context, Ghazanfar et al (2014) reported significant decrease in blood level of glucose in STZ-induced diabetic animals receiving Artemisia amygdalina extract [ 20 ]. The antidiabetic activities of Artemisia judaica , Artemisia annua and Artemisia herba-alba have also been reported [ 21 – 23 ].…”

Antidiabetic effects of artemisia species: A systematic review

“…Their Hypoglycemic effect was comparable with that of the usual hypoglycemic drugs repaglinide, insulin, metformin and glibenclamide. [ 7 15 19 20 ] However, as can be seen from the study of some of those species of Artemisia, such as Artemisia herba-alba have a greater potency in decreasing the serum glucose level and animals treated with this plant showed only mild visible undesirable clinical symptoms whereas the synthetic oral hypoglycemic agents can produce serious side effects. [ 15 ]…”

“…These drugs also have certain adverse effects such as causing hypoglycemia at higher doses, liver problems, lactic acidosis and diarrhea. [ 7 ] Apart from these available therapeutic options, many herbal medicines have been recommended for the treatment of diabetes. Traditional herbal medicines are used throughout the world.…”

In Vivo Anti-Diabetic Activity Evaluation of the Bark of Cascabela Thevetia L. In Streptozotocin Induced Diabetic Rats

“…Blood samples were collected from the tail vein of the overnight (12-15h) fasted rats and blood glucose level was determined on 0th, 5th, 10th and 15th day along with body weight and body temperature. On the 15th day, all the animals were sacrificed and evaluated for the biochemical parameters, histopathology of the pancreas tissue [12,13]. On the 15 th day of treatment, blood was collected from the animals and centrifuged at 4000 rpm for 5 min to separate the serum.…”