Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice.

Miura, Toshihiro; Kubo, Mizue; Itoh, Yasushi; Iwamoto, Naoki; Kato, Motoshi; Park, Sang Rae; Ukawa, Yuuichi; Kita, Yukio; Suzuki, Ikukatsu

doi:10.1248/bpb.25.1234

Cited by 45 publications

(26 citation statements)

References 22 publications

(14 reference statements)

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“…13) Several researchers, among them Yugarani (1992) 14) have demonstrated that flavonoids act as reducers of lipid activities in animals. 15) It has been reported that B. forficata has terpenoids, esteroids and flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity of Bauhinia forficata Extracts in Alloxan-Diabetic Rats

Lino

Diógenes

Pereira

et al. 2004

Biological & Pharmaceutical Bulletin

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The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhinia forficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7 d at doses of 200 and 400 mg/kg, p.o., 48 h after alloxan injection (60 mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use of B. forficata in the treatment of diabetes mellitus type II.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity of Bauhinia forficata Extracts in Alloxan-Diabetic Rats

Lino

Diógenes

Pereira

et al. 2004

Biological & Pharmaceutical Bulletin

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“…Stimulates glucose uptake [81] 51 Kigelia pinnata Bignoniaceae Skeletal muscle cells Stimulates of GLUT4 translocation [82] 52 Krameria lappacea Krameriaceae Cultured myotubes Inhibits human recombinant PTP1B in vitro and enhances insulin-stimulated glucose uptake [83] 53 Lagerstroemia speciosa Lythraceae Rat adipocyte Enhances glucose uptake [84] 54 Larix laricina Pinaceae Diet-induced obese C57BL/6 mice Increases glucose uptake [85] 55 Lindera aggregata Lauraceae HepG2 cells ND [86] 56 Liriope spicata Asparagaceae KKAy mice Increases expression of insulin receptor subunit, IRS-1, PI3K, and peroxisome proliferators-activated receptors γ, inhibits hepatic gluconeogenesis and increases hepatic glycolysis as well as hepatic glycogen content [87] 57 Litsea coreana Lauraceae Rats with hyperlipidemia Regulates effects on the disturbance of lipid metabolism and decreases leptin level [88] 58 Lyophyllum decastes Lyophyllaceae KK-Ay mice increases GLUT4 protein content in the plasma membrane [89] 59…”

Section: Cornus Officinalismentioning

confidence: 99%

Antidiabetic plants improving insulin sensitivity

Eddouks¹,

Bidi²,

Bouhali³

et al. 2014

Journal of Pharmacy and Pharmacology

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Background Globally, the prevalence of diabetes mellitus is increasing at an alarming rate. This chronic pathology gravely troubled the human health and quality of life. Both insulin deficiency and insulin resistance are involved in the pathophysiology of diabetes mellitus. Moreover, insulin resistance is being diagnosed nowadays in a growing population of diabetic and obese patients, especially in industrialized societies. There are lots of conventional agents available to control and to treat diabetes, but total recovery from this disorder has not been reported up to this date. Plants provided a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. A few reviews with less attention paid to mechanisms of action have been published on antidiabetic plants. Objectives The present review focuses on the various plants that have been reported to be effective in improving insulin sensitivity associated with diabetes. Key findings In this work, an updated systematic review of the published literature has been conducted to review the antidiabetic plants improving insulin sensitivity and 111 medicinal plants have been reported to have a beneficial effect on insulin sensitivity using several in-vitro and in-vivo animal models of diabetes. Conclusion The different metabolic and cellular effects of the antidiabetic plants improving insulin sensitivity are reported indicating the important role of medicinal plants as potential alternative or complementary use in controlling insulin resistance associated with diabetes mellitus.

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“…In spite of the presence of known anti-diabetic medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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Herbal medicines are gaining more and more attention all over the world, due to their long historical clinical usage and comparatively less side effects. Standardization of herbal drugs and their quality control is needed with proper integration of modern scientific techniques and traditional knowledge. The analysis and quality control of herbal medicines are moving towards an integrative and comprehensive direction, in order to better address the inherent holistic nature of herbal medicines. The techniques used in standardization of plant material include its morphological, anatomical and biochemical characteristics. The present study highlights the pharmacognostical studies including parameters such as powder analysis by microscopical evaluation, and study of physicochemical parameters i.e. proximate analysis and preliminary phytochemical screening of seed kernel of Caesalpinia bonducella Linn. and fruits and roots of Coccinia indica Wight & Arn. which are used as antidiabetic agents. The present study, thus, will help to provide important information with respect to the proper identification of the plant for utilization in different herbal products.

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Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice.

Cited by 45 publications

References 22 publications

Antidiabetic Activity of Bauhinia forficata Extracts in Alloxan-Diabetic Rats

Antidiabetic Activity of Bauhinia forficata Extracts in Alloxan-Diabetic Rats

Antidiabetic plants improving insulin sensitivity

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