Antidiabetic activity of the mangrove species Ceriops decandra in alloxan‐induced diabetic rats

Abstract

Background: Diabetes is a series of disorders characterized by increased fasting and postprandial glucose concentration and insulin deficiency and/or decreased insulin action. Although there are a number of commercially available drugs for the treatment of diabetes, their long‐term use may cause unwanted side effects. Consequently, many studies are underway to find natural remedies that can effectively reduce the intensity of diabetes. The aim of the present study was to evaluate the antidiabetic activity of the mangrove species Ceriops decandra. Methods: The effects of daily oral administration of an ethanolic extract from the leaves of C. decandra (30, 60, 120 mg/kg) for 30 days on blood glucose, hemoglobin (Hb), HbA1c, liver glycogen and some carbohydrate metabolic enzymes were evaluated in normal and alloxan‐induced diabetic rats. The effects of these extracts were compared with the effect of 30‐days treatment with 0.1 mg/kg, p.o., glibenclamide, a commercially available drug commonly used in the treatment of diabetes. Results: Oral administration of 120 mg/kg extract modulated all the parameters evaluated to levels seen in control rats. The effects of 120 mg/kg extract were comparable to those of glibenclamide. Conclusion: The extract of the mangrove plant C. decandra exhibited promising antidiabetic activity and could be considered for further evaluation in clinical studies and drug development.

Antidiabetic potential of mangrove plants: a review

“…The ethanolic leaf extract of C. decandra (120 mg/kg) showed a significant serum-glucoselowering property in alloxan-induced diabetic mice upon oral administration, which was comparable to those of glibenclamide (0.1 mg/kg bw) (Nabeel et al 2010). The treatment of diabetic rats with ethanolic leaf extracts resulted in an increase in insulin secretion, body weight, Hb levels and decrease in HbA1c levels.…”

“…Increased hexokinase enzyme activity was also reported in the diabetic rats. The possible mechanism underlying the antihyperglycaemic action of C. decandra may be due to the stimulation of surviving β-cells to release more insulin (Nabeel et al 2010). Tiwari et al (2008) reported that the ethanolic leaf extract of C. tagal improved the glucose tolerance of the normoglycaemic rats post sucrose load and also lowered the blood glucose levels in STZ-induced diabetic rats after oral administration at a 250 mg/kg dose.…”

In vitro Antimicrobial Activity of Azadirachta indica (Leaves) against Fish Pathogenic Bacteria Isolated from Naturally Infected Dawkinsia filamentosa (Blackspot barb)

“…In developed countries, 80% of people use traditional medicine, that have been obtained from medicinal plants [18]. In both modern and traditional systems of medicines, the medicinal plants continue to serve as valuable therapeutic agents [19]. The Azadirachta indica (A.…”

Metabolites and bioactivities of Rhizophoraceae mangroves

“…All parts of Ceriops decandra have proven antiviral activity 61 . It also possess promising antibacterial 62 , antiinflammatory 63 , and antidiabetic activity 64 . The leaves and bark extract of C. tagal shows antibacterial activity 65 .…”