Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

Bhardwaj, Alok; Modi, Ketan

doi:10.22159/ijpps.2017v9i10.21455

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…The pathogenesis of diabetes mellitus including the chances of managing the oral administration of hypoglycemic herbal treatment have been extensively studied. Our results of antidiabetic effect of N. Nucifera agree with 8 who proved the reduction effect of alcoholic extract of N. Nucifera on blood glucose level in induced diabetic rats. It was found that the level of A1CHb levels in the rats was reduced to a significant amount.…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies proved the hypolipidemic, antihypertensive and hypoglycemic effects of H. Thebacia and N. Nucifera 14,5,12,7,18,19,8 , and 1 . Our results showed that H. Thebacia and N. Nucifera have significant lowering effect to lipid profile that comprises of the complete levels of cholesterol, as well as Triglycerides including low density lipoprotein.…”

Section: Discussionmentioning

confidence: 88%

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The effect of herbal treatment of Hyphaene Thebaica (Doum) and Nelumbo Nucifera (Lotus) on Induced Hyperlipidemia and Hypertension in Male Wistar Albino Rats

Elmahdy M.F,

Adris M.A,

O. Belih S.S

2022

MLU

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Hyperlipidemia is a condition in medical terms where any lipid profile or else the lipoproteins are increased in the blood stream. Elevated LDL is risky and the best indicator of atherosclerosis risk. Hypertension is one of the most associated disease with dyslipidemia. For HDL-C, the risk of hypertension is supposed to be increased at such low levels. There are various medicinal plants, which are supposed to be a very important source for upcoming chemical substances which are having the potential for therapeutic effects. There are various phenolic as well as flavonoids substances present in Hyphaene Thebaica (Doum). These ingredients usually work as an antioxidant that are very helpful to provide a control towards hyperlipidemic. Hyphaene Thebaica has antimicrobial, antidiabetic antihypertensive, hypolipidemic and antioxidant effects. Yet another element called as Nelumbo Nucifera (Lotus) is very useful for medicinal purposes in terms of Oriental medicine. These plants are very hypolipidemic, antioxidant activity, antipyretic, antiplatelet activity and hypoglycemic activity.Objective of the study: to estimate the effects of doum and lotus methanolic extracts on hyperlipidemia, hypertension and diabetes on lipid profile parameters and hypertension parameters like angiotensin converting enzyme and aldosterone. Material and Methods:The study in this paper was done on fourth rats with the species of Wistar Albino. These rats are divided in to four groups and all are male samples. First one was control group and hyperlipidemia and hypertension induced in three groups. Feeding hyperlipidemic and hypertensive rats with extract of doum in third group and lotus extract in fourth group. Results:The effect of both extracts on lipid profile parameters, Angiotensin converting enzyme and aldosterone were parallel in significant lowering them. Doum had strong effect on body weight but lotus had strong effect on fasting blood glucose level.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 88%

The effect of herbal treatment of Hyphaene Thebaica (Doum) and Nelumbo Nucifera (Lotus) on Induced Hyperlipidemia and Hypertension in Male Wistar Albino Rats

Elmahdy M.F,

Adris M.A,

O. Belih S.S

2022

MLU

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“…This results in fragmentation of DNA by means of production of ROS. STZ causes massive destruction of β-cells of the islets of Langerhans resulting in the insulin synthesis and secretion [16]. The toxic effect of STZ is not restricted to abolishment of pancreatic β-cells but also causes oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Streptozotocin-Induced Oxidative Stress in Diabetic Rats - A Defensive Effect of Psydrax Dicoccos

Kumar

P²

2018

Asian J Pharm Clin Res

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Objective: The present study was aimed to evaluate the antihyperglycemic activity and in vivo antioxidant effect of methanolic extract of whole plant of Psydrax dicoccos (MEPD) belonging to the family Rubiaceae.Methods: MEPD was prepared by Soxhlet extraction. Wistar rats weighing (180–200 g) were divided into six groups (n=6), with three doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg of extract. Metformin was used as a standard drug. Diabetes was induced by streptozotocin (STZ) (40–50 mg/kg, i.p) in control group. The animals were treated with different doses of extracts for 21 days, and on the 22nd day, the blood glucose levels along with antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and lipid peroxidase (LPO) were determined.Results: The phytochemical screening of the extract showed the presence of carbohydrates, phenolics, flavonoids, glycosides, and tannins. The methanolic extract of MEPD at the dose of 200 mg/kg body weight showed a significant reduction in blood glucose levels (**p<0.001) with the value of 151.2 mg/dl on the 22nd day at 8 h. A promising antioxidant effect was also evident from the determination of antioxidant enzymes such as SOD, CAT, and LPO.Conclusion: The P. dicoccos extract revealed a potential effect of antihyperglycemic activity and combating nature on oxidative stress induced by STZ.

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“…5 Seeds are used in folk medicines as treatment of tissue inflammation, cancer, skin disease, and leprosy. 6…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Nelumbo nucifera Plant on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Rats

Patel

Kumbhani

Raval

2022

ANAMS

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Objectives Ulcerative colitis is a global disease with increasing incidence and worldwide prevalence. So this study was undertaken to observe antiulcerative colitis activity of ethanolic extract of seeds of Nelumbo nucifera plant on dextran sodium sulfate (DSS)-induced ulcerative colitis in rats. Materials and Methods The effect of ethanolic extract of N. nucifera seed (EENNS) was studied on DSS-induced ulcerative colitis in albino Wistar rats for 11 days. Disease pathogenesis was assessed by evaluation of disease activity index (DAI) including the following parameters: change in body weight, stool constituency, rectal bleeding in animals. Estimation of myeloperoxide (MPO), nitric oxide (NO), and antioxidant parameters like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase level was performed in colon homogenate of animals. TNF-α (tumor necrosis factor- α) level was measured in colon homogenate using rat TNF-α ELISA kit. Statistical Analysis Significant differences (mean ± standard error of the mean) were detected using one-way analysis of variance followed by post-test using Graphpad prism 7.0 for multiple comparisons. Results EENNS (400 mg/kg) significantly improved the disease progression, body weight, and colon length of the animals as compared with the disease control group. Animal treated with EENNS (400 mg/kg) showed significantly improved colon mucosal damage index (1.66 ± 0.21) and DAI (11.66 ± 4.01) as compared with the disease control group. A higher level of SOD and catalase and a lower level of MDA were observed in animals treated with EENNS (400 mg/kg) as compared with the disease control group. Animals treated with EENNS (400 mg/kg) significantly decreased in NO and MPO levels as compared with the disease control group. A lower level of TNF-α (561.94 ± 14.84) was observed in EENNS (400 mg/kg)-treated animals as compared with the disease control group (736.92 ± 15.3). These observations were comparable to those of the standard control group. Histopathological data showed that EENNS (400 mg/kg) has shown reversal of tissue inflammation as compared with the disease group and evidence of less cell infiltration of lymphocytes and monocytes with normal structures of goblet cell and crypts as compared with the disease group. Conclusions EENNS (400 mg/kg) is endowed with severity of the ulcerative colitis produced by DSS. EENNS showed a protective effect against DSS-induced ulcerative colitis which may be due to its antioxidant and anti-inflammatory activity.

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Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

Cited by 7 publications

References 39 publications

The effect of herbal treatment of Hyphaene Thebaica (Doum) and Nelumbo Nucifera (Lotus) on Induced Hyperlipidemia and Hypertension in Male Wistar Albino Rats

The effect of herbal treatment of Hyphaene Thebaica (Doum) and Nelumbo Nucifera (Lotus) on Induced Hyperlipidemia and Hypertension in Male Wistar Albino Rats

Streptozotocin-Induced Oxidative Stress in Diabetic Rats - A Defensive Effect of Psydrax Dicoccos

Protective Effect of Nelumbo nucifera Plant on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Rats

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