Antidiabetic and antihyperlipidaemic potential of Amaranthus viridis (L.) Merr. in streptozotocin induced diabetic rats

Pandhare, Ramdas; Sadasivam, Balakrishnan; Mohite, Popat; Khanage, Shantaram Gajanan

doi:10.1016/s2222-1808(12)60148-0

Cited by 14 publications

(4 citation statements)

References 15 publications

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“…Oral administration of methanolic leaf extract of A. spinosus [68] and methanolic whole plant extract of A. viridis [69] showed significant reduction in elevated blood glucose, MDA and restored GSH, CAT, TT levels in alloxan-induced oxidative stress in diabetic rats as compared to diabetic control. Oral administration of A. viridis stem aqueous extract in STZ induced diabetic rats, significantly decreased blood glucose level and modulated lipid profile [70]. Ethanolic extract of leaves of A. spinosus, significantly decreased plasma glucose levels (p < 0.01 and p < 0.001), hepatic glucose-6-phophatase activity (p < 0.01 and p < 0.001); increased the hepatic glycogen content (p < 0.01) with a concurrent increase in hexokinase activity in both type 1 and 2 diabetic rats (p < 0.01 and p < 0.001).…”

Section: Antidiabetic Propertiesmentioning

confidence: 90%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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Extracts of Amaranthus have been used to treat several ailments since ancient times. However, Amaranthus spp. has seen a resurgence of interest in recent decades. Literature summarization of in vitro and in vivo studies established that Amaranthus spp. has several protective and curative properties attributed majorly to strong antioxidant activity. This comprehensive review critically analyzes folklore claims of Amaranthus with scientific evidences, delineating its phytochemical based nutrapharmaceutical properties and emphasizes clinical utility of the plant in various chronic diseases, also defining gap areas for future clinical research. Data on 13 edible Amaranthus spp. was acquired via an electronic search including regional scientific journals, theses, books and government reports. These results provide an in-depth analysis of biological effects of major bioactive ingredients present in crude extracts of specific bioparts. However, bioavailability and underlying mechanism of action of constituents isolated from Amaranthus spp. have not been worked out, thus necessitating focused research in this arena.

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Section: Antidiabetic Propertiesmentioning

confidence: 90%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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“…Obese rats receiving atorvastatin also showed reduced blood glucose levels and AUC, but the results were not so prominent. Different studies suggest that A. spinosus is capable of improving the glycemic conditions in both diabetic and nondiabetic animal models (39)(40)(41)(42). Several mechanisms have been proposed behind the antidiabetic and glucose-lowering capacity of this plant.…”

Section: Amaranthus Spinosus Ameliorated Glucose Intolerance In Obese Ratsmentioning

confidence: 99%

Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

et al. 2021

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Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by A. spinosus. Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.

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“…However, Grubben and Denton (2004) reported its use as diuretic, purgative, and anti-inflammatory. Antidiabetic and anti-hyperlipidemic potential of the species has also been highlighted (Kumar et al 2012;Pandhare et al 2012). The leaves of A. viridis are particularly rich in proteins, vitamin A, and iron (Yang and Keding 2009).…”

mentioning

confidence: 99%

Diversity and Differential Utilization of Amaranthus spp. along the Urban-Rural Continuum of Southern Benin

Sogbohossou

Achigan‐Dako

Komlan³

2015

Econ Bot

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Diversity and Differential Utilization of Amaranthus spp. along the Urban-Rural Continuum of Southern Benin. Increasing recognition of the importance of traditional vegetables as sources of nutrients, health benefits, and income has raised the need to evaluate and document knowledge of these resources in local communities. Indigenous knowledge is crucial for sustainable utilization of these plant resources, though this might be threatened by urbanization and economic development. We carried out a quantitative ethnobotanical survey to assess the relative importance of amaranth in vegetable production systems of southern Benin and identify the main criteria that determine the choice of this crop by farmers. The diversity, uses, and knowledge of amaranths was investigated to assess how the degree of urbanization affects farmers' knowledge. Our results showed that Amaranthus cruentus is the main cultivated vegetable in the surveyed areas despite its low economic value. Reasons raised by communities were related to the species' popularity, resistance to nematodes, nutritional value, and short cultivation cycle. Wild amaranths include A. dubius, A. blitum, A. spinosus, and A. viridis. Amaranths were mainly used as vegetables and for their nutraceutical properties. Urbanization was found to negatively affect the knowledge and uses of wild species, whereas the knowledge and utilization of cultivated species was quite homogenous along the urban-rural continuum. We discuss strategies to increase knowledge of wild resources in urban settings and therefore reduce loss of genetic resources.Diversité et utilisation des amarantes (Amaranthus spp.) le long du continuum urbain-rural au Sud-Bénin. La reconnaissance croissante de la valeur nutritionnelle des légumes locaux, leurs bienfaits pour la santé et leur contribution au revenu des populations a révélé la nécessité d'évaluer et de documenter les connaissances associées à ces espèces au sein des communautés locales. En effet, les connaissances endogènes considérées comme importantes pour la conservation et l'utilisation des ressources phytogénétiques pourraient être en voie de disparition du fait de l'urbanisation et du développement économique. La présente étude a porté sur une enquête ethnobotanique réalisée le long du continuum urbain-rural au Sud-Bénin afin d'évaluer l'importance relative des amarantes et d'identifier les principaux critères qui déterminent le choix de cette culture par les agriculteurs. En outre, la diversité, les usages et les connaissances des amarantes ont été étudiés afin d'évaluer comment le degré d'urbanisation affecte les connaissances des agriculteurs. Nos résultats ont montré que Amaranthus cruentus est la principale espèce cultivée dans les zones étudiées en dépit de sa faible valeur économique. Les 1 , Bronx, NY 10458-5126 U.S.A. raisons évoquées par les producteurs étaient liées à la popularité de l'espèce, sa résistance aux nématodes, sa valeur nutritionnelle et son cycle de culture court. Les amarantes sauvages : A. dubius, A. blitum, A. spi...

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Antidiabetic and antihyperlipidaemic potential of Amaranthus viridis (L.) Merr. in streptozotocin induced diabetic rats

Cited by 14 publications

References 15 publications

Rediscovering the therapeutic potential of Amaranthus species: A review

Rediscovering the therapeutic potential of Amaranthus species: A review

Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

Diversity and Differential Utilization of Amaranthus spp. along the Urban-Rural Continuum of Southern Benin

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