Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats

Latifi, Ebrahim; Mohammadpour, Ahmad Ali; H, Behrooz Fathi; Nourani, Hossein

doi:10.1016/j.biopha.2018.10.152

Cited by 56 publications

(27 citation statements)

References 37 publications

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“…This study revealed that the extract of E.alata protected the lipid disturbances induced by the Triton X-100, which are expressed by a decrease in the intensity of the red colouring in histological sections stained with red-oil O. Similar effects have been reported by other authors [17,31]. Table III shows the dose -effect of the methanolic extract of female cones of Ephedra alata as well as the standard anti-inflammatory drug (indomethacin) administered in groups of rats that received acetic acid (0.1%).…”

Section: Variations In the Activity Of Tissue Antioxidant Enzymessupporting

confidence: 89%

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Chouikh¹

2020

FARMACIA

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The aim of this study is the estimation of the antioxidant, analgesic and hypolipidemic effects and the chromatographic analysis of the extract of female cones of Ephedra alata which is growing in South East Algeria. The extract of E. alata showed better inhibition of DPPH• radical, the highest reductive activity and gave the best protection of erythrocytes. The HPLC analyses has identified eight phenolic compounds: gallic acid, chlorogenic acid, vanillic acid, vanillin, p-coumaric acid, rutin, naringenin and quercetin. The results of the protective effect of hyperlipidaemia caused by Triton X-100 showed that there are noticeable changes in the biochemical and lipid parameters, also for the parameters of oxidative stress in the group exposed to Triton X-100. Also, the treatment with the methanol extract of E. alata yielded similar results to the control batches by normalizing and decreasing the biochemical, stress and lipid parameters. The histological study confirmed the biochemical results. According to the results of the analgesic activity, the extract of E. alata induced a significant decrease in abdominal writhings compared to the control group and the values obtained are very close to those obtained with indomethacin. Rezumat Scopul acestui studiu a fost evaluarea efectelor antioxidante, analgezice, hipolipemiante și analiza cromatografică a extractului de conuri femele de Ephedra alata, din sud-estul Algeriei. Extractul de E. alata a arătat o inhibiție mai bună a radicalului DPPH •, cea mai ridicată activitate reducătoare și a oferit cea mai bună protecție asupra eritrocitelor. Analizele HPLC au identificat opt compuși fenolici: acid galic, acid clorogenic, acid vanilic, vanilină, acid p-cumaric, rutină, naringenină și quercetină. Rezultatele efectului protector asupra hiperlipemiei cauzate de Triton X-100 au arătat că există modificări vizibile ale parametrilor biochimici și lipidici, de asemenea, pentru parametrii stresului oxidativ din grupul expus la Triton X-100. De asemenea, tratamentul cu extract metanolic de E. alata a scăzut parametrii biochimici, stresul oxidativ și parametrii lipidici. Studiul histologic a confirmat rezultatele biochimice. Acțiunea analgezică a extractului de E. alata a indus o scădere semnificativă a contorsiunilor comparativ cu grupul martor și valorile obținute sunt foarte apropiate de cele obținute în cazul administrării de indometacin.

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Section: Variations In the Activity Of Tissue Antioxidant Enzymessupporting

confidence: 89%

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Chouikh¹

2020

FARMACIA

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“…6 Ethanol extract of asafoetida gum has been shown to enhance insulin secretion and to reduce fasting sugar levels in Wistar rats, and it functions as a hypoglycemic and hypolipidemic agent. 7 Chinese physicians use asafoetida extract to treat heart diseases. 8 Asafoetida is used for many respiratory ailments, including H1N1 swine flu.…”

Section: Introductionmentioning

confidence: 99%

<p>Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum</p>

Devanesan

Karuppiah

AlSalhi

et al. 2020

IJN

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Purpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties. Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively. Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6-8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50-and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained. Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.

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“…Accumulating studies have shown that oral quercetin treatment can significantly reduce plasma total cholesterol (T‐CHO) level in diabetic animal models (Eitah et al, ; Latifi, Mohammadpour, Fathi, & Nourani, ; Zhang, Dong, Wang, & Zhang, ). Being synthesized from cholesterol in the liver, bile acids (BAs) represents a major pathway for the elimination of steroids from the body (Chavez‐Talavera, Tailleux, Lefebvre, & Staels, ; T. Yang, Khan, et al, ; Yang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Yang

Cai

et al. 2019

Phytotherapy Research

185

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Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated. T2DM‐induced NAFLD and quercetin treatment models were established in vivo and in vitro. The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers. Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid (p = .0001) and the decreased liver total bile acid (p = .0005), quercetin could reduce lipid accumulation in the liver of db/db mice. Further mechanism studies showed that farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathways was involved in quercetin regulation of lipid metabolism in T2DM‐induced NAFLD. In high D‐glucose and free fatty acid cocultured HepG2 cells model, quercetin eliminated lipid droplets and restored the upregulated total cholesterol and triglyceride levels. Similar to the findings in mice, quercetin could also activate farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathway. These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.

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Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats

Cited by 56 publications

References 37 publications

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

<p>Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum</p>

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

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