Antidiabetic and antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar rats

Varghese, Sincy; Kannappan, Poornima; Devaki, Kanakasabapathi; Madathil, SriRashmy; Muneeswari, Perumalsamy

doi:10.1016/j.bcab.2021.102095

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…This impairment results in a reduction in glycolysis, ultimately leading to a signi cant increase in hyperglycemia. Previous research studies [51,52] have demonstrated a correlation between decreased insulin levels and altered HK activity, which is consistent with our ndings. In contrast, our study observed a stimulation of hepatic HK activity in diabetic rats administered with CPC.…”

Section: Discussionsupporting

confidence: 94%

WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism

Saїdi,

Al-Shaikh,

Hamden

2024

Preprint

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Background in recent years, it has become necessary to use natural food colorants to protect against different diseases and disorders. The present study aimed to purify, evaluate the stability, and investigate the effect of purified Spirulina C-Phycocyanin (CPC) on digestive and metabolic enzymes linked to hyperglycemia. Methods the purification of CPC was performed using column chromatography to isolate compounds and reversed-phase high performance liquid chromatography combined with diode array detector (DAD) and ultraviolet spectroscopy (DAD-HPLC-UV) and infrared Fourier transform (FTIR). Results the findings of this study indicate that CPC is stable at temperatures below 45°C and at a pH range of 5 to 7, as well as during storage at 4°C. In diabetic rats, the ingestion of CPC by diabetic rats suppressed key enzymes related to inflammation in pancreas, such as 5-Lipoxygenase (5-LO), hyaluronidase (HAase), myeloperoxidase (MPO), and NADPH oxidase (NOX2 activities) by 48, 41, 75, and 47%, respectively. Additionally, it reduced the pancreas thiobarbituric acid reactive substance rates (TBARS) by 59%, and stimulated the level of nitric oxide (NO) by approximately 164%. Moreover, CPC powerfully suppressed intestinal lipase, α-amylase, maltase, and sucrose activities, and significantly decreased glycosylated hemoglobin (HbA1c). Furthermore, CPC ingestion by diabetic rats suppressed glycogen phosphorylase (GP), stimulated Glycogen synthase (GS) activities, and regulated glycogen content in the liver of diabetic rats. In addition, CPC supplementation to diabetic rats modulated hepatic key enzymes of carbohydrate metabolism in the liver, such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase (G6P), and fructose-1,6-bisphosphatase (FBP), as well as average food and water intake (AFI and AWI), resulting in a decrease in blood glucose level by 56% compared to untreated diabetic rats. Conclusion Overall, the results of this research showed that CPC can be used as a functional food coloring as well as a compound to prevent various pathologies such as ulcers, oxidative stress, inflammation and metabolic diseases.

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Section: Discussionsupporting

confidence: 94%

WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism

Saїdi,

Al-Shaikh,

Hamden

2024

Preprint

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“…In another study performed by Varghese et al, the antidiabetic and antilipidemic effects of an ethanolic extract of Clerodendrum paniculatum flowers were evaluated in vivo [34]. The rats were divided into five groups (control, diabetic control, diabetic rats administered with glibenclamide, diabetic rats administered with 200 mg/kg extract, and normal rats treated with 200 mg/kg extract), and the authors observed that the groups treated with extract and glibenclamide had a significant increase in the HDL level and a decrease in TG, LDL, VLDL, and TG values, being in line with the control group [34]. These results are in line with the present study, highlighting the potential to prevent and reduce some diseases such as diabetes, hypertension, or hepatocarcinoma.…”

Section: Biochemicalmentioning

confidence: 99%

Insights into the 3D In Vitro Permeability and In Vivo Antioxidant Protective Effects of Kiwiberry Leaf Extract: A Step Forward to Human Nutraceutical Use

Silva

Almeida

Dall’Acqua

et al. 2022

IJMS

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Actinidia arguta (Siebold & Zucc.) Planch. ex Miq. (kiwiberry) leaves are a source of phenolic compounds with pro-health biological effects, such as antioxidant and anti-inflammatory activities. Despite the huge number of studies reporting the composition of A. arguta leaves, no in vitro or in vivo studies explore its potential use as nutraceutical ingredient based on these activities. Therefore, this study aims to characterize the safety profile of kiwiberry leaf extracts using in vitro and in vivo approaches through the assessment of intestinal cell viability (Caco-2 and HT29-MTX), 3D intestinal permeation, and, most important, the redox markers, biochemical profile and liver and kidney function effects after the animal assays. Briefly, wistar rats were orally treated for 7 days with kiwiberry leaf extracts (50 and 75 mg/kg bw), water (negative control), or vitamin C (positive control). The cell viability was above 90% at 1000 μg/mL for both cells. Coumaroyl quinic acid and rutin achieved a permeation higher than 25% in the 3D intestinal model. The animal studies confirmed the extracts’ ability to increase superoxide dismutase, glutathione peroxidase, and catalase content in animals’ livers and kidneys while simultaneously decreasing the triglycerides content. This study highlighted the antioxidant capacity of kiwiberry leaf extracts, ensuring their efficacy and safety as a nutraceutical ingredient.

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“…However, the results of the research did not find such records. Clerodendrum paniculatum flower has antidiabetic and antilipidemic effect 22 and hepatoprotective activity. 23 The people of Nias use Coix lacryma-jobi L. as an antihypertensive drug.…”

Section: Discussionmentioning

confidence: 99%

Ethnomedicine In Nias Island

Zebua,

Nerdy,

Dachi

et al. 2024

Pharmacogn J.

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Background: Medicinal plants have an important role in the traditional medicine system of the Nias people, which has been passed down from generation to generation. Although there has been some ethnobotanical research in Indonesia, especially in Nias, studies regarding people's knowledge, use and perception of medicinal plants on this island are still very limited. Objective: to investigate the knowledge, use and perceptions of the Nias community towards medicinal plants. Design: The research population involved communities in various areas of Nias, and samples were taken randomly from several villages or communities. Data collection methods include questionnaires, interviews, and observations to detail the use of medicinal plants, local knowledge, and factors that influence the choice and use of medicinal plants. The research variables involve the demographic characteristics of respondents, education level, access to health information as independent variables, while the dependent variables include the use of medicinal plants and knowledge about medicinal plants.. Results: As a result of data collection on respondents on Nias Island, there were 50 medicinal plants that people have often used for generations to treat diseases. Data analysis involved analyzing factors related to the use of medicinal plants. It is hoped that this research will provide a better understanding of the use of medicinal plants in Nias and contribute to the preservation of local knowledge and the development of public health strategies. Conclusion: Most of the empirical data submitted by the local Nias community is in accordance with research that has been carried out, however, there are 13 plants that need to be explored further because the empirical data does not match.

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Antidiabetic and antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar rats

Cited by 9 publications

References 31 publications

WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism

WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism

Insights into the 3D In Vitro Permeability and In Vivo Antioxidant Protective Effects of Kiwiberry Leaf Extract: A Step Forward to Human Nutraceutical Use

Ethnomedicine In Nias Island

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