Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin

Zhang, Li; Yang, Jie; Chen, Xiaoqing; Zan, Ke; Wen, Xin; Chen, Hong; Wang, Qiang; Lai, Mao-Xiang

doi:10.1016/j.jep.2010.08.053

Cited by 102 publications

(60 citation statements)

References 31 publications

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“…However, we date to note that, after ischemia-reperfusion in the brain, markedly decreased levels of SOD1 and 2 were found in the HFD-ischemiagroup. This result is consistent with a previous study that HFD (58 % fat) induced diabetic rats, which resulted in decreased levels of antioxidant enzymes [46]. Therefore, after ischemia-reperfusion, more decreased levels of antioxidants induced by the HFD resulted in exacerbated effects on ischemia-induced neuronal death.…”

Section: Discussionsupporting

confidence: 93%

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

et al. 2014

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In this study, we investigated the effects of a normal diet (ND) and high-fat diet (HFD) on delayed neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia. In the HFD-fed gerbils, ischemia-induced hyperactivity was significantly increased and neuronal damage was represented more severely compared to the ND-fed gerbils. Ischemia-induced glial activation was accelerated in the HFD-fed gerbils. Cytokines including interleukin-2 and -4 were more sensitive in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. Additionally, we found that decreased 4-HNE and SODs immunoreactivity and protein levels in the hippocampal CA1 region of the HFD-fed gerbils after ischemia-reperfusion. These results indicate that HFD may lead to the exacerbated effects on ischemia-induced neuronal death in the hippocampal CA1 region after ischemia-reperfusion. These effects of HFD may be associated with more accelerated activations of glial cells and imbalance of pro- and anti-inflammatory cytokines and/or antioxidants after transient cerebral ischemia.

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Section: Discussionsupporting

confidence: 93%

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

et al. 2014

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“…Our results showed that diabetes caused significant increase in lipid peroxides as indicated by a significant increase in TBARS concentration accompanied by a concomitant significant (p < 0.01) decrease in the activity of GSH, SOD and CAT in liver tissue of diabetic rats as compared with normal control rats. These results are consistent with those of the previous studies which have shown an increase in the TBARS level and a decrease in the levels of the GSH, SOD and CAT levels (Wang et al 2011;Zhang et al 2010). Treatment of diabetic rats with E. ribes extract had reversed the activities of these antioxidants in the liver, which might be due to decreased oxidative stress as evidenced by decreased lipid peroxidation.…”

Section: Discussionsupporting

confidence: 92%

Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

Bhandari

Chaudhari

Khanna

et al. 2013

Frontiers in Life Science

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Embelia ribes is extensively used in the traditional Indian system of medicine for treatment of various disorders. We herein investigated the antidiabetic effects of E. ribes ethanolic extract in high fat diet (HFD) and low dose streptozotocin (STZ)-induced type 2 diabetes in Wistar rats. HFD-fed and low dose STZ (35 mg kg −1 , i.p)-induced diabetic rats were treated with E. ribes extract (100 and 200 mg kg −1 day −1 ) or metformin (180 mg kg −1 day −1 ) for 21 days while continuing on HFD. Antihyperglycemic effects of E. ribes extract were demonstrated by significant reduction (p < 0.01) in fasting blood glucose, hepatic glucose-6-phosphatase activity and increased glycogen content, whereas insulin sensitizing effects were seen during oral glucose tolerance testing. In addition, it significantly (p < 0.01) restored the elevated systolic and diastolic blood pressure, reduced hepatic fatty degeneration, oxidative changes and the reversal of circulating levels of serum lipids, lipase, insulin, leptin and adiponectin towards normal in diabetic rats. These findings demonstrated the antidiabetic potential of E. ribes extract in HFD-fed and low dose STZ-treated diabetic rats. This may be associated with strong antioxidant potential and restoration of the serum levels of leptin, adiponectin, insulin and lipids.

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“…This may be evident by a decrease of pancreatic islets size, degranulation of cells, vacuolation and invasion of connective tissues in those of the diabetic control group. 20 The possible mechanism of blood glucose reduction produced by plant extracts could be explained by different mechanisms. Some plants may contain insulin-like substances.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure of histological studies of pancreas was adapted according to the study by Zhang et al (2010). 20 After blood collection, all rats were sacrificed.…”

Section: Histological Studiesmentioning

confidence: 99%

Hypoglycemic Activity of Leaf Extracts from Tiliacora triandra in Normal and Streptozotocin-Induced Diabetic Rats

Katisart¹,

Rattana²

2017

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Background: Tiliacora triandra is a common plant found in southeast Asian countries. It is traditionally used as anti-pyrogenic agent. Objective: The present study was aimed to investigate the hypoglycemic activities leaf extracts from Tiliacora triandra (TTE) in normal and streptozotocin-induced diabetic rats. Methods: TTE was prepared and daily and orally administered at dose of 300 mg/kg b.w. to the rats for 8 weeks. The body weight and blood glucose level were measured weekly. At the end of the experiments, blood samples were collected from cardiac puncture and analyzed for serum insulin levels. The pancreatic tissues were stained by hematoxylin-eosin for histo-pathological investigations. Results: Normal and diabetic rats treated with TTE and glibenclamide tended to have an increased body weight. TTE significantly decreased the blood glucose level by 25.01 ± 19.77% in week 3 in diabetic rats and similar to that of glibenclamide group (27.01 ± 11.89%). However, the extracts slightly decreased the blood glucose level in normal rats by 9.48 ± 2.14% in week 2. TTE significantly increased serum insulin level by 21.63 ± 1.39 IU/mL in diabetic rats compared to the controls (10.63 ± 0.37 IU/mL) but not in normal rats. In additions, TTE activated the regeneration of pancreatic Islets of Langerhans in diabetic rats which in turn stimulated insulin secretion. Conclusion: TTE exhibits the hypoglycemic potential by stimulating insulin secretion from the pancreas.

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Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin

Cited by 102 publications

References 31 publications

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Effects of High-Fat Diet on Neuronal Damage, Gliosis, Inflammatory Process and Oxidative Stress in the Hippocampus Induced by Transient Cerebral Ischemia

Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

Hypoglycemic Activity of Leaf Extracts from Tiliacora triandra in Normal and Streptozotocin-Induced Diabetic Rats

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