Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

Tiong, Soon Huat; Looi, Chung Yeng; Hazni, Hazrina; Arya, Aditya; Paydar, Mohammadjavad; Wong, Won Fen; Cheah, Shiau‐Chuen; Mustafa, Mohd Rais; Awang, Khalijah

doi:10.3390/molecules18089770

Cited by 243 publications

(153 citation statements)

References 33 publications

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“…Phytochemicals have been shown to be responsible for the antidiabetic effect of many medicinal and plant foods through their interaction with critical enzymes involved in carbohydrate metabolisms (Ademiluyi & Oboh, 2012). This function has been attributed majorly to the phenolic compounds (Toma et al., 2014) and recently, to some alkaloids (Tiong et al., 2013). Hence, factors that negatively affect the amounts and bioavailability of these compounds may significantly impact their antidiabetic properties.…”

Section: Discussionmentioning

confidence: 99%

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Ademiluyi

Aladeselu

Oboh

et al. 2018

Food Science & Nutrition

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Moringa oleifera leaf is a popular green leafy vegetable which has found its usefulness in the preparation of traditional stews and soups. Like most green leafy vegetable which are not around year‐round, the leaf is usually dried and pulverized for storage and easier handling, and despite the popularity of this processing technique, there is dearth of information on how drying affects the health‐promoting properties of the leaves. Hence, this study sought to investigate the effect of some drying methods (freeze‐drying, sun, air and oven drying) on the phytoconstituents, antioxidant properties, and biological activities of moringa leaf. This study revealed that drying methods significantly altered the phytoconstituents (phenolics, flavonoids, vitamin C, tannin, saponin, phytate, oxalate, alkaloid, cardenolides, and cardiac glycosides), antioxidant capacities (reducing power, Fe2+chelating, ABTS •+, DPPH, and • OH scavenging abilities), and enzyme inhibitory (α‐amylase and α‐glucosidase) effects of the leaf, with freeze‐drying being the most promising method for preserving the nutraceutical properties of moringa leaf. However, for practical application, the order of preference of the drying methods which ensures adequate retention of phytoconstituents and possibly biological activities of the leaf as observed in this study is freeze‐drying > air drying > sun drying > oven drying, in the order of decreasing magnitude.

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Section: Discussionmentioning

confidence: 99%

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Ademiluyi

Aladeselu

Oboh

et al. 2018

Food Science & Nutrition

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“…The periwinkle plant produces secondary metabolites that are active as alkaloid anticancer agents. (9,14) On the other hand, periwinkle extract has been shown to reduce telomerase expression, as has been shown in T47D cell cultures in the treatment group at ½ IC50 and 1 IC50. Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomers.…”

Section: Discussionmentioning

confidence: 60%

“…(6,9) An extract of its flowers also has hyperglycemic effects in diabetic rats and functions as antioxidant, antibacterial, anthelminthic, and antidiarrheal agent. (9)(10)(11) A number of cancer cells have a high telomerase activity and each type of cancer cell may have different degrees of telomerase expression according to the type or location of the cancer. This can be used as a basis for the treatment of cancer cells if there are substances that can inhibit the activity of the telomerase enzyme.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic periwinkle leaf extract reduces telomerase expression in T47D cancer cells

Purwaningsih¹,

Widayanti²,

Suciati³

2015

UnivMed

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BACKGROUNDCancer cells have a relatively high telomerase activity and a lower p53 protein expression than normal cells, so that cancer cells have the ability to continue to proliferate and do not undergo apoptosis. One of the cancer treatments is chemotherapy using bioactive ingredients from synthesis or isolation of natural materials. One of the plants that have potential as anticancer agent is periwinkle (Catharanthus roseus L). The research objective was to evaluate the effect of ethanolic periwinkle leaf extract against p53 protein and telomerase expression in T47D cancer cells.

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“…The blood sugar lowering effect could be associated to alkaloids present [18]. Alkaloid fraction from C. decidua has been shown to have antidiabetic activity in mice [19].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity of Administration of Aqueous Extract of Berberis holstii

Kimani¹,

Njangiru²,

Njagi³

et al. 2017

J Diabetes Metab

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Diabetes mellitus in Kenya is of public health concern since it causes significant mortality and complications that are long term. Though conventional drugs are used in the management of diabetes mellitus they are expensive, unavailable and also have numerous side effects. Berberis are medicinally important and are used for various purposes. Berberis holstii has traditionally been used in the management of diabetes; however, the efficacy of this herb needs to be evaluated scientifically.The study aimed at determining the in vivo antidiabetic effects of root extracts of Berberis holstii in alloxaninduced diabetic male mice. In this study, eight groups of animals with five mice each were used. The reductions in blood glucose relative to their initial values were determined after oral and intraperitoneal administration of 25, 48.4, 93.5, 180.9, and 350 mg/kg body weight. Standard hypoglycemic used to compare results were 200 mg/kg body weight (4.6 mg of glibenclamide) for oral route and 1 IU/kg body weight dose of insulin for an intraperitoneal route. The levels of glucose were measured at the start of the experiment and repeated at intervals of 2 hours up to 10 hours and at 24 hours after administering the drug. Significant (ρ<0.05) reduction in blood sugar relative to their initial values was determined for all treated diabetic groups at the end of the experiment. The composition of phytochemicals was determined using standard procedures. The results were analyzed using ANOVA and post-ANOVA.The results showed that the plant extract at 25, 48.4, 93.5, 180.9, and 350 mg/kg body weight administered effectively reduced blood glucose levels (up to 30% reduction) which could be associated with the phytochemicals present which possesses antidiabetic activities. The extracts contained tannins, flavonoids, saponins, phenols and alkaloids. The study, therefore, recommends the use of Berberis holstii in the management of diabetes mellitus.

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Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

Cited by 243 publications

References 33 publications

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Ethanolic periwinkle leaf extract reduces telomerase expression in T47D cancer cells

Antidiabetic Activity of Administration of Aqueous Extract of Berberis holstii

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