Antidiabetic and Haematological Effects of Chrysophyllum albidum Supplemented Diet on Streptozotocin Induced Diabetic Rats

Abstract

Background: The use of food in the management of diseases is an established art of science. It is essentially important in the management of chronic diseases such as diabetes mellitus where cure is not certain.
 Objective: This study investigated the anti-diabetic and heamatological effects of Chrysophyllum albidum fruit-skin (CAFS) supplemented diet on streptozotocin induced diabetic rats.
 Methods: Diabetes mellitus was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin (STZ) and 70g/kg CAFS supplemented diet was used on STZ-induced diabetic rats to test its antidiabetic efficacy with some biochemical parameters and histological evaluation of liver and pancreatic tissues for a treatment period of twenty-eight days.
 Results: The diabetic untreated rats exhibited hyperglycaemia accompanied with increases in glycosylated haemoglobin, plasma and liver lipid profile except high density lipoprotein-cholesterol (HDL-c) and white blood cell count while decreasing the body weight, insulin, hepatic glycogen and red blood cell levels. CAFS was significantly (p<0.05) effective in inhibiting hyperglycemia by 68%, decreased glycosylated haemoglobin by 20%, plasma and liver lipid profile except HDL-c and white blood cell count but increased the body weight by 17%, insulin, hepatic glycogen and red blood cell levels in comparison with diabetic untreated group. The results were comparable to glibenclamide (standard-drug). Histopathological studies on liver and pancreas of CAFS-treated rats showed regenerative effects.
 Conclusion: This study has indicated that CAFS possesses antihyperglycemic, antihyperlipidemic and ameliorative effect on diabetic induced abnormalities in haematological parameters, β-cell and liver tissue. The findings suggest that CAFS may be used as therapeutic adjunct in the management of diabetes.

DETERMINATION OF THE PHYTOCHEMICALS, MINERALS, PROXIMATE AND ANTIBACTERIAL CONSTITUENTS OF THE LEAF, STEM, ROOT AND SEED OF Ficus capensis (BUSH FIG)

“…Iron content of Ficus capensis was in the order root > leaf > seed > and stem. The level of iron in this work agreed with the work of Ujowundu et al[35] that found low iron in the seeds of Dacryodes eldulus but did not agree with the work of Ibrahim et al[36]. Iron performs several functions in the body.…”

Hepatic- and Renal protective Effects of Chrysophyllum albidum (African Star Apple) Fruit-Skin Supplementation on Streptozotocin-Induced Diabetic Rats

“…However, treatment of diabetic rats with CAFS supplementation reversed the altered levels of plasma K + , Na + , HCO3and Clto near normal values, indicating the renal protective role of CAFS in diabetic rats. Our previous studies demonstrated that C. albidum fruit skin is a potent radical scavenging agent (Ibrahim et al, 2019a), hypolipidemic and hypoglycemic agents (Ibrahim et al, 2019b) and thus, suggests its protective role that could ameliorate the development of diabetic complications such as hepatopathy and nephropathy.…”

“…Previously, we reported the antioxidant effect of C. albidum fruit skin extracts that was associated with flavoniods and phenolic contents (Ibrahim et al, 2019a). In addition, the hypolipidemic and antihyperglycemic potentials of C. albidum fruit skin in STZ-induced diabetic rats was demonstrated (Ibrahim et al, 2019b). The aim of the present study was to explore the effect of C. albidum fruit skin supplementation on liver and kidney function parameters of STZ-induced diabetic rats.…”

“…Two diets were formulated according to the recommendations of National Academy of Sciences (1995) on nutrients requirement for laboratory rats for growth and maintenance as described in our previous study (Ibrahim et al, 2019b). Normal control (NC) diet, which is free of C. albidum fruit-skin (CAFS) and Test (CAFS) diet, which was supplemented with 70g/kg CAFS.…”

“…Researches indicate that, DM is associated with a number of liver abnormalities that affect glycogen and lipid metabolism (Sanchez et al, 2000;Bolkent et al, 2004;Koyuturk et al, 2005). Our previous study demonstrated that persistent hyperglycemia caused significant reduction in the liver glycogen levels and elevation of plasma and hepatic lipids (except high-density lipoprotein (HDL)) contents in diabetic rats (Ibrahim et al, 2019b). Another studies by Chiang et al (2011), Birkenfeld and Shulman (2014) as well as Nakahara et al (2014) found that DM causes liver disease, such as hepatic steatosis, nonalcoholic steatohepatitis, fibrosis and cirrhosis.…”