Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica

Reza, Md. Sharif; Shuvo, Md. Sadikur Rahman; Hassan, Mahadi; Basher, Mohammad Anwarul; Islam, Abu Zafor Md. Touhidul; Naznin, Nura Ershad; Jafrin, Sarah; Ahmed, Khondoker Shahin; Hossain, Hemayet; Daula, A F M Shahid Ud

doi:10.1016/j.biopha.2020.110942

Cited by 14 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study showed that stigmasterol also increases total insulin and improves insulin secretion in cells exposed to glucolipotoxicity [ 120 ]. Recently, Reza et al [ 121 ] reported the possible mechanism underlying the anti-diabetic properties of stigmasterol-rich Aeginetia indica . The molecular docking analyses revealed stigmasterol binding to sirtuin 4, an NAD-dependent deacylase enzyme that down-regulates leucine- and glutamate-dehydrogenase-induced insulin secretion.…”

Section: Anti-diabetic Effectsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Stigmasterol

et al. 2022

View full text Add to dashboard Cite

Stigmasterol is an unsaturated phytosterol belonging to the class of tetracyclic triterpenes. It is one of the most common plant sterols, found in a variety of natural sources, including vegetable fats or oils from many plants. Currently, stigmasterol has been examined via in vitro and in vivo assays and molecular docking for its various biological activities on different metabolic disorders. The findings indicate potent pharmacological effects such as anticancer, anti-osteoarthritis, anti-inflammatory, anti-diabetic, immunomodulatory, antiparasitic, antifungal, antibacterial, antioxidant, and neuroprotective properties. Indeed, stigmasterol from plants and algae is a promising molecule in the development of drugs for cancer therapy by triggering intracellular signaling pathways in numerous cancers. It acts on the Akt/mTOR and JAK/STAT pathways in ovarian and gastric cancers. In addition, stigmasterol markedly disrupted angiogenesis in human cholangiocarcinoma by tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor receptor-2 (VEGFR-2) signaling down-regulation. The association of stigmasterol and sorafenib promoted caspase-3 activity and down-regulated levels of the anti-apoptotic protein Bcl-2 in breast cancer. Antioxidant activities ensuring lipid peroxidation and DNA damage lowering conferred to stigmasterol chemoprotective activities in skin cancer. Reactive oxygen species (ROS) regulation also contributes to the neuroprotective effects of stigmasterol, as well as dopamine depletion and acetylcholinesterase inhibition. The anti-inflammatory properties of phytosterols involve the production of anti-inflammatory cytokines, the decrease in inflammatory mediator release, and the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Stigmasterol exerts anti-diabetic effects by reducing fasting glucose, serum insulin levels, and oral glucose tolerance. Other findings showed the antiparasitic activities of this molecule against certain strains of parasites such as Trypanosoma congolense (in vivo) and on promastigotes and amastigotes of the Leishmania major (in vitro). Some stigmasterol-rich plants were able to inhibit Candida albicans, virusei, and tropicalis at low doses. Accordingly, this review outlines key insights into the pharmacological abilities of stigmasterol and the specific mechanisms of action underlying some of these effects. Additionally, further investigation regarding pharmacodynamics, pharmacokinetics, and toxicology is recommended.

show abstract

Section: Anti-diabetic Effectsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Stigmasterol

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Liver is a crucial metabolic organ and displays an essential role in safeguarding several physiological procedures within the body. This organ performs multidimensional functions including nutrients metabolism, maintaining body homeostasis, and involved in the detoxi cation of xenobiotics, drugs, pollutants and chemotherapeutics (1,2). Liver diseases have become a worldwide problem and fatalities related to hepatic diseases are rising to an alarming rate (3).…”

Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Pandit

Kumar

Kaur

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole and it is a principal aromatic component of star anise possessed several therapeutic properties. Results showed that CCl 4 treatment elevated the levels of different serum markers like serum glutamate oxaloacetate transaminase (SGOT) by 4.74 fold, serum glutamate pyruvate transaminase (SGPT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold and total bilirubin by 2.38 fold in contrast with control. It was observed that decreased levels of various liver antioxidant enzymes viz. CAT, GR, and GSH were signi cantly ameliorated by the pre-administration of rats with different doses (40, 80, and 160 mg kg -1 bw) of trans-Anethole. Furthermore, pre-treatment of trans-Anethole reduced phase I enzymes level, whereas elevated level of phase II detoxifying enzymes. Furthermore, histopathological examination showed that the treatment with trans-Anethole was potent in defending the liver from CCl 4 toxic injury and restored normal hepatic architecture. Also, trans-Anethole regulated p53 and Cyclin D1 expressions in liver tissue relative to group II treated with CCl 4 . Collectively, the ndings of the study showed a strong e ciency of trans-Anethole in ameliorating the effects caused by CCl 4 through modulation of antioxidants and xenobiotic-metabolizing enzymes.

show abstract

“…Aeginetia indica and celastrol have been shown to be potential treatments for hepatotoxicity induced by APAP. 16, 17 DHM is a flavonoid isolated from ampelopsis. Previous studies have proved that DHM has a certain protective effect on chemical and alcoholic liver damage.…”

Section: Discussionmentioning

confidence: 99%

Evaluation on Hepatoprotection of Dihydromyricetin in Acetaminophen-Induced Hepatotoxicity Based on Analysis of Inflammation and Apoptosis Mediated by PI3K/AKT Pathway

Gong

Zhang

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

Purpose: We aimed to investigate whether dihydromyricetin (DHM) could alleviate acetaminophen (APAP)-induced liver damage in mice, and to verify whether the process is associated with the PI3K/AKT signaling pathway. Methods: The contents of DHM in serum and related physiological indicators in blood and liver tissue were measured, respectively. We used haematoxylin and eosin (H&E), TUNEL, Hoechst 33,258, immunofluorescence assay and western blot methods to comprehensively assess the protective mechanism and therapeutic effect of DHM on liver damage induced by APAP (250 mg/kg) in mice. Results: APAP (250 mg/kg) could increase the expression of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) and cause 4-hydroxy-2-nonenal (4-HNE) and Cytochrome P450 2E1 (CYP2E1) overexpression and stress response in the PI3K/AKT pathway. DHM was also detected in the serum of mice about five minutes after administration. DHM pretreatment could reverse GSH depletion and CYP2E1 overexpression, reduce the expression of ALT, AST, malondialdehyde, 4-HNE, TNF-α, and IL-1β, meanwhile it could reverse the abnormal expression of PI3K/AKT signaling pathway-related proteins which were induced by APAP. DHM pretreatment significantly reduced APAP-induced liver tissue apoptosis, necrosis, and inflammatory infiltration. Conclusion: DHM had a hepatoprotective effect on hepatotoxicity induced by APAP, which was shown by inhibiting oxidative stress and inflammatory responses, and reducing hepatocyte apoptosis by activating the PI3K/AKT signaling pathway.

show abstract

Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica

Cited by 14 publications

References 36 publications

Health Benefits and Pharmacological Properties of Stigmasterol

Health Benefits and Pharmacological Properties of Stigmasterol

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Evaluation on Hepatoprotection of Dihydromyricetin in Acetaminophen-Induced Hepatotoxicity Based on Analysis of Inflammation and Apoptosis Mediated by PI3K/AKT Pathway

Contact Info

Product

Resources

About